Abstract. This paper describes the 2006 lecture and conference meeting speech-to-text system developed at the Interactive Systems Laboratories (ISL), for the individual head-mounted microphone (IHM), single distant microphone (SDM), and multiple distant microphone (MDM) conditions, which was evaluated in the RT-06S Rich Transcription Meeting Evaluation sponsored by the US National Institute of Standards and Technologies (NIST). We describe the principal differences between our current system and those submitted in previous years, namely improved acoustic and language models, cross adaptation between systems with different front-ends and phoneme sets, and the use of various automatic speech segmentation algorithms.