Open access epidemiological data from the COVID-19 outbreak

Xu, Bo; Kraemer, Moritz U. G.; Gutiérrez, Bernardo; Mekaru, Sumiko R.; Sewalk, Kara; Loskill, Alyssa; Wang, Lin; Cohn, Emily; Hill, Sarah C.; Zarebski, Alexander E.; Li, Sabrina; Wu, Chieh-Hsi; Hulland, Erin; Morgan, J.; Scarpino, Samuel V.; Brownstein, John S.; Pybus, Oliver G.; Pigott, David M.

doi:10.1016/s1473-3099(20)30119-5

Cited by 241 publications

(242 citation statements)

References 3 publications

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“…SARS-CoV-2 infection is a very serious public health issue. It caused a nationwide spread in China, and now has the tendency to spread all over the world, causing a surge in infections and deaths [6]. So far, there is no specific drug for SARS-CoV-2, and challenges remain.…”

Section: Discussionmentioning

confidence: 99%

“…Spike (S) protein, one of the main structural proteins of SARS-CoV-2, binds angiotensin-converting enzyme 2 (ACE2) protein of the host cell membrane to fuse into the cell for nucleic acid replication just similar to SARS-CoV [5]. Through a variety of bioinformatics and experimental verification, ACE2 is not only expressed in alveolar epithelial cells, but also in the heart, gastrointestinal tract, kidney, testis and other organs, which means that SARS-CoV-2 is likely to enter other tissues and organs through ACE2 binding, causing multiple organ damage [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…In recent studies, SARS-CoV-2 has been found to cause heart, kidney, liver injury and gastrointestinal symptoms in addition to lung lesions such as ARDS [6]. However, there is lacking attention in pancreatic injury, which may accelerate patients' progression.…”

Section: Introductionmentioning

confidence: 99%

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Highly ACE2 Expression in Pancreas May Cause Pancreas Damage After SARS-CoV-2 Infection

Liu

Long

Zou

et al. 2020

Preprint

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The ongoing outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started in the end of 2019 in China has triggered a global public health crisis. Previous studies have shown that SARS-CoV-2 infects cells by binding angiotensin-converting enzyme 2 (ACE2), which is the same as SARS-CoV. The expression and distribution of ACE2 in the pancreas are unknown. At the same time, the injury of pancreas after SARS-CoV-2 infection has not been concerned. Here, we collected public datasets (bulk RNA-seq and single-cell RNA-seq) to indicate the expression and the distribution of ACE2 in pancreas (in both exocrine glands and islets). And further, clinical data including mild and severe patients with COVID-19 demonstrated there existed mild pancreatitis. In the 67 severe cases, 11 patients (16.41%) showed elevated levels of both amylase and lipase, and 5 patients (7.46%) showed imaging alterations. Only one patient (1.85%) showed elevated levels of both amylase and lipase in 54 mild cases, without imaging changes. Our study revealed the phenomenon and possible cause of mild pancreatic injury in patients with COVID-19. This suggests that pancreatitis after SARS-CoV-2 infection should also be paid attention in clinical work.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Highly ACE2 Expression in Pancreas May Cause Pancreas Damage After SARS-CoV-2 Infection

Liu

Long

Zou

et al. 2020

Preprint

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“…5,10 Though this data is often difficult to obtain at the start of an outbreak, thanks to the efforts of multiple academic teams in curating line list data from multiple sources, we have been able to gain some insight into the current COVID-19 outbreak in children. 4,5 Though this data cannot replace official data and analyses provided by national and international health agencies, it can enable rapid analysis of data and dissemination of key information in the preliminary stages of an outbreak when minimal other data is available, and, as applied in this study, early data on specific subsets of patients. 5 This study combined data from two crowdsourced line lists to obtain a sample of pediatric patients with COVID-19 in order to gain some preliminary insights into the outbreak in children and adolescents.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, for international cases, data Chinese local, provincial, and national health authorities. 4 Their data is freely available online via Google Drive.…”

Section: Methodsmentioning

confidence: 99%

Preliminary epidemiological analysis on children and adolescents with novel coronavirus disease 2019 outside Hubei Province, China: an observational study utilizing crowdsourced data

Henry

Oliveira

2020

Preprint

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BackgroundThe outbreak of coronavirus disease 2019 continues to expand across the world.Though both the number of cases and mortality rate in children and adolescents is reported to be low in comparison to adults, limited data has been reported on the outbreak with respect to pediatric patients. To elucidate information, we utilized crowdsourced data to perform a preliminary epidemiologic analysis of pediatric patients with COVID-19 MethodsIn this observational study, data was collected from two open-access, line list crowdsourced online databases. Pediatric cases of COVID-19 were defined as patients ≤19 years of age with a laboratory confirmed diagnosis. The primary outcomes were case counts and cumulative case counts.Secondary outcomes included days between symptoms onset and first medical care and days between first medical care and reporting. Tertiary outcomes were rate of travel to Wuhan, rate of infected family members and rates of symptoms. ResultsA total of 82 patients were included. The median age was 10 [IQR: 5-15] years. Patients from mainland China (outside Hubei) accounted for 46.3% of cases, while the remaining 53.7% of cases were international. Males and females accounted for 52.4% and 32.9% of cases, respectively, with the remaining 14.6% being designated as unknown. A male skew persisted across subgroup analyses by age group (p=1.0) and location (inside/outside China) (p=0.22). While the number of reported international cases has been steadily increasing over the study period, the number of reported cases in China rapidly decreased from the start point. The median reporting delay was 3[IQR: 2-4.8] days. The median delay between symptom onset and first seeking medical care was . CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.is the (which was not peer-reviewed) The copyright holder for this preprint .

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Global academic response to COVID‐19: Cross‐sectional study

et al. 2020

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This study explores the response to COVID-19 from investigators, editors, and publishers and seeks to define challenges during the early stages of the pandemic. A cross-sectional bibliometric review of COVID-19 literature was undertaken between 1 November 2019 and 24 March 2020, along with a comparative review of Middle East respiratory syndrome (MERS) literature. Investigator responsiveness was assessed by measuring the volume and type of research published. Editorial responsiveness was assessed by measuring the submission-to-acceptance time and availability of original data. Publisher-responsiveness was assessed by measuring the acceptance-to-publication time and the provision of open access. Three hundred and ninety-eight of 2,835 COVID-19 and 55 of 1,513 MERS search results were eligible. Most COVID-19 studies were clinical reports (n = 242; 60.8%). The submission-to-acceptance [median: 5 days (IQR: 3-11) versus 71.5 days (38-106); P < .001] and acceptance-to-publication [median: 5 days (IQR: 2-8) versus 22.5 days (4-48Á5-; P < .001] times were strikingly shorter for COVID-19. Almost all COVID-19 (n = 396; 99.5%) and MERS (n = 55; 100%) studies were open access. Data sharing was infrequent, with original data available for 104 (26.1%) COVID-19 and 10 (18.2%) MERS studies (P = .203). The early academic response was characterized by investigators aiming to define the disease. Studies were made rapidly and openly available. Only one-in-four were published alongside original data, which is a key target for improvement.

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Open access epidemiological data from the COVID-19 outbreak

Cited by 241 publications

References 3 publications

Highly ACE2 Expression in Pancreas May Cause Pancreas Damage After SARS-CoV-2 Infection

Highly ACE2 Expression in Pancreas May Cause Pancreas Damage After SARS-CoV-2 Infection

Preliminary epidemiological analysis on children and adolescents with novel coronavirus disease 2019 outside Hubei Province, China: an observational study utilizing crowdsourced data

Global academic response to COVID‐19: Cross‐sectional study

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