Open access clinic providing HIV-I antibody results on day of testing: the first twelve months.

Squire, S. Bertel; Elford, Jonathan; Bor, Robert; Tilsed, G; Salt, Heather; Bagdades, Evis; Jánossy, G.; Griffiths, Paul; Ma, Jun

doi:10.1136/bmj.302.6789.1383

Cited by 38 publications

(16 citation statements)

References 11 publications

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“…Here we also demonstrate the findings on 25 unselecled homosexual men whose HIV-1 seropositiviiy was consecutively diagnosed at an Open Access Clinic [29]. This seropositive cohort had a mean age of 30-1 years (range 18-47).…”

Section: Hiv-l Seropositive Groupsupporting

confidence: 62%

“…Finally, (vi) IOO HIV homosexual men with an average age of 33 7 years (range 19-61) were either volunteer partners of patients with known seropositivity or attended the Open Access Clinic [29].…”

Section: Seronegative Groupsmentioning

confidence: 99%

“…The same parameters were also analysed in 25 HIV-l p atients attending an open access clinic [29], In 23 (93'/.,) inverted CD4/CDS ratio were seen, and 17 (6S%) had CD4 lymphopenia <0-4>: lO*"//with 64'^o coincidence (Fig. 4).…”

Section: Extreme Low Cd4 Values and Related Parameters In Control Grmentioning

confidence: 99%

“…During the last 5 years we have accumulated control ranges in different groups of seronegative individuals, such as heterosexual volunteers, patients with coagulation disorders [6,28] and homosexual men [29] who arc regarded as the appropriate controls for HIV-1* patients as exposures to various factors other than HIV-I may alter T lymphocyte subsets. An advantage of investigating patients wilh clotting disorders is thai ihcy regularly atlcnd haemophilia services for longitudinal studies.…”

Section: Introductionmentioning

confidence: 99%

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Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV-1 diagnosis

Bofill

Jánossy

Lee

et al. 1992

Clinical and Experimental Immunology

Self Cite

195

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SUMMARYWith the advent of standard flow cytometric methods using two-colour fluorescence on satnpies of whole blood, it is possible to establish the ranges of CD3, CD4 and CD8 T lymphocyte subsets in the routine laboratory, and also to assist the definition of HIV-l-re!ated deviations from these normal values. In 676 HIV-I-seronegative individuals the lymphocyte subset percentages and absolute counts were determined. The samples taken mostly in the morning. The groups included heterosexual controls, people with various clotting disorders but without lymphocyte abnormalities as well as seronegative homosexual men as the appropriate controls for the HIV-I-infected groups. The stability of CD4"/ values was demonstrated throughout life, and in children CD4 values <25% could be regarded as abnormal. The absolute counts ofall Tcell subsetsdeereased from birth until the age of ID years. In adolescents and adults the absolute numbers {mean±s.d.) of lymphocytes, CD3. CD4 and CD8 eells were I 90 + 0-55. I 45 + 046. 083+029 and 056 + 0 23 X iO'*//, respectively. In patients with haemophilia A and B the mean values did not differ signifieantly. In homosexual men higher CD8 levels were seen compared with heterosexual men and 27"/;. had an inverted CD4/CD8 ratio but mostly without CD4 lymphopenia {CD4<04x 107/), However, some healthy uninfected people were 'physiologieally' lymphopenic without having inverted CD4/CD8 ratios. When the variations "within persons" were studied longitudinally over a 5-year period, the absolute CD4 counts tended to be fixed al different levels. As a marked contrast, over 60% of asymptomatic HIV-I ' patients exhibited low CD4 counts <04x 10"//together with inverted CD4/CD8 ratios. Such combined changes among the heterosexual and HIV-1-seronegative homosexual groups were as rare as 14% and 3%. respectively. For this reason, when the lymphoeyte tests show < 0-4 X IO**// CD4 eount and a CD4/CD8 ratio ofless than unity, the individuals need to be investigated further for ehronicity of this disorder, the signs of viral infections sueh as HIV-I and other eauses of immunodeficiency.

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Section: Hiv-l Seropositive Groupsupporting
confidence: 62%

Section: Seronegative Groupsmentioning
confidence: 99%

Section: Extreme Low Cd4 Values and Related Parameters In Control Grmentioning
confidence: 99%

Section: Introductionmentioning
confidence: 99%

See 2 more Smart Citations
Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV-1 diagnosis
Bofill
¹
,
Jánossy
²
,
Lee
³

et al. 1992
Clinical and Experimental Immunology
Self Cite
195
11
87
0
View full text Add to dashboard Cite
SUMMARYWith the advent of standard flow cytometric methods using two-colour fluorescence on satnpies of whole blood, it is possible to establish the ranges of CD3, CD4 and CD8 T lymphocyte subsets in the routine laboratory, and also to assist the definition of HIV-l-re!ated deviations from these normal values. In 676 HIV-I-seronegative individuals the lymphocyte subset percentages and absolute counts were determined. The samples taken mostly in the morning. The groups included heterosexual controls, people with various clotting disorders but without lymphocyte abnormalities as well as seronegative homosexual men as the appropriate controls for the HIV-I-infected groups. The stability of CD4"/ values was demonstrated throughout life, and in children CD4 values <25% could be regarded as abnormal. The absolute counts ofall Tcell subsetsdeereased from birth until the age of ID years. In adolescents and adults the absolute numbers {mean±s.d.) of lymphocytes, CD3. CD4 and CD8 eells were I 90 + 0-55. I 45 + 046. 083+029 and 056 + 0 23 X iO'*//, respectively. In patients with haemophilia A and B the mean values did not differ signifieantly. In homosexual men higher CD8 levels were seen compared with heterosexual men and 27"/;. had an inverted CD4/CD8 ratio but mostly without CD4 lymphopenia {CD4<04x 107/), However, some healthy uninfected people were 'physiologieally' lymphopenic without having inverted CD4/CD8 ratios. When the variations "within persons" were studied longitudinally over a 5-year period, the absolute CD4 counts tended to be fixed al different levels. As a marked contrast, over 60% of asymptomatic HIV-I ' patients exhibited low CD4 counts <04x 10"//together with inverted CD4/CD8 ratios. Such combined changes among the heterosexual and HIV-1-seronegative homosexual groups were as rare as 14% and 3%. respectively. For this reason, when the lymphoeyte tests show < 0-4 X IO**// CD4 eount and a CD4/CD8 ratio ofless than unity, the individuals need to be investigated further for ehronicity of this disorder, the signs of viral infections sueh as HIV-I and other eauses of immunodeficiency.
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“…Counsellors and doctors were available at 4 pm to give the results to the patients on the same day. 1 Results from our Same-Day Testing Clinic since it opened in March 1990 to the end of June 1998 are presented in the Table. Clearly, it can be seen that this service is being accessed by patients at risk of HIV since approximately 3% of attenders are HIV-infected.…”

Section: The Same-day Testing Clinicmentioning
confidence: 98%

Testing for HIV antibodies should be offered on a same-day basis
Clewley
¹
,
Mattes
²
,
Johnson
³

1998
Rev. Med. Virol.
1
0
0
0
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Testing for HIV antibodies should not be offered on a same-day basis
Rice
¹
,
Chrystie
²

1998
Rev. Med. Virol.
0
0
0
0
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Open access clinic providing HIV-I antibody results on day of testing: the first twelve months.

Cited by 38 publications

References 11 publications

Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV-1 diagnosis

Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV-1 diagnosis

Testing for HIV antibodies should be offered on a same-day basis

Testing for HIV antibodies should not be offered on a same-day basis

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