OPathPaed service model for expanded newborn screening in Hong Kong SAR, China

The first pilot study of expanded newborn screening for inborn errors of metabolism and survey of related knowledge and opinions of health care professionals in Hong Kong

“…In 2013, the hospital-based OPathPaed model was published for the implementation of an expanded NBS programme suitable for a local setting. 19 The present study further confirms the feasibility of the OPathPaed model for use on a larger scale. The OPathPaed model integrates expert input from obstetricians, pathologists, and paediatricians.…”

“…The OPathPaed model for expanded NBS was used for evaluation. 19 The OPathPaed model includes 10 steps: parental education, consent, sampling, sample dispatch, dried blood spot (DBS) preparation and testing, reporting, recall and counselling, confirmation test, treatment and monitoring, and cost-benefit analysis (Fig 1).…”

Expanded newborn metabolic screening programme in Hong Kong: a three-year journey

“…However, little attention has been paid to IEM screening until recently. 15 The Department of Health and Hospital Authority have done a pilot study on newborn screening for IEM in two public hospitals since October 2015. The establishment of the CIEM and its expanded newborn screening programme in 2013 has made this kind of screening service more readily accessible to local parents who understand the significance of IEM and opt for a private screening service for their newborn babies.…”

“…14 A pilot study using an OPathPaed service model for expanded newborn screening in a regional public hospital in Hong Kong was conducted between July and November 2010. 15 The Centre of Inborn Errors of Metabolism (CIEM) of the Chinese University of Hong Kong started a private expanded newborn metabolic screening programme in July 2013 with participants from multiple centres. This study describes the results and screening outcome of this newborn screening programme in the past 3 years.…”

Cost-benefit analysis of Hyperphenylalaninemia Due to 6-Pyruvoyl-Tetrahydropterin Synthase (PTPS) Deficiency: For Consideration of Expanded Newborn Screening in Hong Kong

“…[16][17][18][19] In 2013 the first pilot study on expanded NBS in public hospitals demonstrated a feasible service model (''namely the OPathPaed model'') for expanded NBS in Hong Kong. 20 We therefore carried out a cost-benefit analysis on screening for 6-pyruvoyl-tetrahydropterin synthase (PTPS) deficiency, one of the more frequently occurring disorders likely to be detected by MS/MS. The incidence of hyperphenylalaninemias in Hong Kong is 1 in 29,542; all Hong Kong Chinese patients with hyperphenylalaninemias were genetically confirmed to have PTPS deficiency.…”