Opacification of the Intraocular Lens After Descemet Stripping Endothelial Keratoplasty

Nieuwendaal, Carla P.; Meulen, Ivanka J.E. van der; Patryn, Eliza K.; Werner, Liliana; Mourits, Maarten P.; Lapid-Gortzak, Ruth

doi:10.1097/ico.0000000000000574

Cited by 29 publications

(22 citation statements)

References 20 publications

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“…Intraocular lens (IOL) opacification is a serious condition that may degrade patients' vision. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Although opacification has often been associated with hydrophilic IOLs, 2, 5, 7, 9-15, 17, 18 this postoperative complication has also been reported in other lens materials. 1,3,6,16 Studies on calcification of hydrophilic acrylic IOLs have pointed to several factors that may be related to the onset of opacification, such as lens packaging, 4 ophthalmic viscosurgical device, 8 surgical technique, 19 patient related conditions, 6 and most recently, intracameral injection of gas.…”

Section: Introductionmentioning

confidence: 99%

Assessment of straylight and the modulation transfer function of intraocular lenses with centrally localized opacification associated with the intraocular injection of gas

Łabuz¹,

Yildirim²,

Berg³

et al. 2018

Journal of Cataract and Refractive Surgery

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Section: Introductionmentioning

confidence: 99%

Assessment of straylight and the modulation transfer function of intraocular lenses with centrally localized opacification associated with the intraocular injection of gas

Łabuz¹,

Yildirim²,

Berg³

et al. 2018

Journal of Cataract and Refractive Surgery

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“…Despite the marked progress in the field of new materials and intraocular implant production technology, the incidence of IOL opacification is common. [345678910111213141516] IOL opacification is a rare but significant complication after DSAEK. The incidence of IOL opacification after DSAEK ranged from approximately 5% of 160 eyes (8 eyes)[11] to 9.7% of 154 eyes (15 eyes)[7] in a large number of patients.…”

Section: Discussionmentioning

confidence: 99%

“…IOL opacification resulted in foggy and blurred vision and decreased visual acuity in patients. [11] The opacification is typically located on the anterior surface or subsurface of IOLs and is defined by the pupillary or capsulorhexis margin in a confluent patch and circular pattern. [47]…”

Section: Discussionmentioning

confidence: 99%

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Intraocular lens opacification after Descemet's stripping automated endothelial keratoplasty

Lee

Tsai

et al. 2017

Taiwan J Ophthalmol

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Compared with conventional penetrating keratoplasty, Descemet's stripping automated endothelial keratoplasty (DSAEK) more effectively maintain global integrity and rapid vision rehabilitation with less ocular surface disorders in patients with endothelial dysfunction. Here, we report a case of a 76-year-old woman who experienced opacification of a hydrophilic intraocular lens (IOL) approximately 10 months after DSAEK. The patient with no history of systemic disease developed pseudophakic bullous keratopathy in the right eye 2 years after undergoing cataract surgery. The best-corrected visual acuity (BCVA) of the right eye was Snellen 0.01 when presented to our hospital. DSAEK was arranged and performed smoothly. However, the graft detached over the upper part of the cornea on postoperative day 1. Thus, rebubbling was performed immediately. After the procedure, the graft was well attached, and the cornea became clear gradually. The BCVA returned to Snellen 0.6. However, progressive opacification over the anterior surface of the IOL was observed 10 months postoperatively. Vision deteriorated to 0.5 with various refractive errors during 2-year follow-up. IOL exchange may be considered if the vision is getting worse. IOL opacification may result from a direct contact between the IOL surface and exogenous air, particularly in a hydrophilic IOL, and can be a rare but significant complication after DSAEK. Clinicians planning to perform DSAEK should consider the composition of the IOL, the amount of intracameral air, duration of air filling, and high intraocular pressure.

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“…Of the 45 articles, five did not fulfil the inclusion criteria and were excluded from further analysis. The remaining included articles numbered 40 and were analysed using the Pierson tool …”

Section: Methodsmentioning

confidence: 99%

Systematic review of potential causes of intraocular lens opacification

Fernández

Sánchez‐García

Rodríguez‐Vallejo³

et al. 2019

Clinical Exper Ophthalmology

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Intraocular lens (IOL) opacification is an infrequent complication of cataract sur-gery. Surface analysis has demonstrated that the opacification of IOLs is related to calcium or phosphate precipitation on or within the lenses, but the associated mechanisms are unknown, and the scientific literature is heterogeneous and limited to case series and retrospective studies. The purpose of this systematic review was to analyse the most frequent conditions associated with opacification of IOLs reported by studies. A search was carried out using the PubMed MEDLINE, Web of Science and Scopus databases. The quality of the studies selected was evaluated using the Pierson tool. The search provided a total of 811 articles, of which 39 were selected following the inclusion and exclusion criteria. The most common opacified lenses were hydrophilic IOLs according to our analysis. The mean time of appearance of lens opacification was 14.93 ± 17.82 months. The most frequent conditions associated with opacification of the IOLs were Descemet Stripping with Automated Endothelial Keratoplasty (DSAEK/DSEK) and diabetes mellitus (DM), followed by pars plana vitrectomy (PPV), blood hypertension (HT), and glaucoma.Concerning the quality analysis, the mean score was 7.00 ± 1.43 (scoring range from 0 to 10), indicating an acceptable quality of the case reports and retrospective studies. In conclusion, DSAEK/DSEK, DM, PPV, glaucoma and hypertension are conditions with potential risk of IOL opacification after cataract surgery, especially when implanting hydrophilic acrylic IOLs. K E Y W O R D Sacrylic IOL, cataract surgery, intraocular lens, IOL explantation, IOL opacification

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Opacification of the Intraocular Lens After Descemet Stripping Endothelial Keratoplasty

Abstract: Opacification of the IOL can be a vision-threatening late complication after DSEK and was seen in 8 of 160 eyes.

Cited by 29 publications

References 20 publications

Assessment of straylight and the modulation transfer function of intraocular lenses with centrally localized opacification associated with the intraocular injection of gas

Assessment of straylight and the modulation transfer function of intraocular lenses with centrally localized opacification associated with the intraocular injection of gas

Intraocular lens opacification after Descemet's stripping automated endothelial keratoplasty

Systematic review of potential causes of intraocular lens opacification

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