OP53 Molecular biomarkers in peripartum cardiomyopathy: a systematic review and meta-analysis

Abstract

Results Stroke event rates for baseline and Q20 cohorts were 3.1 and 8.4 per 1000 person years respectively. At baseline, healthier levels of three LS7 -BP, physical activity and smoking were associated with reduced risk of stroke. HRs [95% Confidence Intervals] for intermediate and ideal (vs poor) were 0.62 [0.49, 0.79] and 0.41 [0.24, 0.69] for BP; 0.68 [0.49, 0.95] and 0.55 [0.39, 0.79] for physical activity; and 0.68 [0.54, 0.86] and 0.57 [0.43, 0.77] for smoking. For exposures measured at Q20, only BP maintained a protective association (HRs 0.84 [0.66, 1.06] and 0.50 [0.30, 0.84] for intermediate and ideal levels respectively). Protection from each unit increase in overall CVH scores also weakened with age. With reference to the Low-Low trajectory, all trajectories were generally associated with reduced risk. The HRs were Low-High 0.57 (0.41, 0.79); High-Low 0.85 (0.61, 1.19) and High-High 0.77 (0.58, 1.03) respectively. Conclusion Not all components of CVH individually influence stroke. While the association between CVH and stroke weakens with age, improving overall CVH may bring some benefit even in later life.