Op49 a Low Cost Primary Prevention Tool: Effects of Non Pharmacological Lifestyle Modification in Prevention of Type 2 Diabetes Mellitus in Young Urban Sri Lankan – “Diabrisk-Sl”

Wijesuriya, Mahen; Karalliedde, Janaka; Gulliford, Martin; Vasantharajah, Laksha; Viberti, G.; Gnudi, Luigi

doi:10.1016/s0168-8227(14)70255-4

Cited by 2 publications

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“…These four factors were chosen on the basis of a pilot study that identified these risk-factors as being highly prevalent in 1239 subjects aged below 40 years with a new diagnosis of T2DM who attended the National Diabetes Centre in Colombo between 2005–2007 and are supported by recent data from comparable South Asian and Sri Lankan populations [1], [4], [7], [8].…”

Section: Methodsmentioning

confidence: 99%

High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population

Wijesuriya¹,

Gulliford

Charlton

et al. 2012

PLoS ONE

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BackgroundSouth-Asian's are predisposed to early onset type 2 diabetes (T2DM). The prevalence of cardio-metabolic risk-factors in young Sri-Lankans is unknown.Methodology/Principal FindingsTo determine by questionnaire and anthropometry the prevalence of first degree family history (FH) of T2DM, physical inactivity, raised waist circumference (WC) and raised body mass index (BMI) in a representative healthy urban population selected by cluster sampling. Those with ≥2 risk-factors were evaluated for metabolic syndrome (MS) and recruited for an intervention trial. Of 23,296 participants screened, 22,507 (53% Female) were eligible [8,497 aged 10–14 yrs, 4,763 aged 15–19 yrs and 9,247 aged 20–40 yrs]. 51% had none of the 4 risk-factors, 26% 1 risk-factor and 23% (5,163) ≥2 risk-factors of whom 4,532 were assessed for MS. Raised BMI was noted in 19.7% aged 10–14 yrs, 15.3% between 15–19 yrs, and between 20–40 yrs, 27.4% of males vs. 21.8% of females p<0.001. Prevalence of raised WC was greater in females for each age group: 42.7% vs. 32.1%; 28.1% vs. 16.1%; 34.5% vs. 25.7% (p<0.05 for all) as was physical inactivity: 39.9% vs. 14.5%; 51.7% vs. 20.0%; 62.7% vs. 41.3% which rose in both sexes with age (p<0.05 for all). FH of T2DM was present in 26.2%. In 4532 (50%<16 yrs) with ≥2 risk-factors, impaired fasting glycaemia/impaired glucose tolerance (pre-diabetes) prevalence was 16%. MS was more prevalent in males [10–16 yrs (13.0% vs. 8.8%), 16–40 yrs (29.5% vs. 20.0%) p<0.001 for both].Conclusions/SignificanceThere is a high prevalence of modifiable cardio-metabolic risk-factors in young urban Sri-Lankans with significant gender differences. A primary prevention intervention trial is ongoing in this cohort. Clinical Trial Registration Number SLCTR/2008/World Health Organization (WHO) international clinical trial registry platform.

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Section: Methodsmentioning

confidence: 99%

High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population

Wijesuriya¹,

Gulliford

Charlton

et al. 2012

PLoS ONE

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“…For example, the DIABRISK-SL [55] RCT in Sri Lanka aims to compare an intensive (3 months) lifestyle modification advice to a less-intensive (12 monthly; control group) lifestyle modification advice on a primary composite cardio-metabolic endpoint, in at-risk (two or more of the following: obesity, elevated waist circumference, family history of diabetes, or physically inactive) urban subjects aged between 5 and 40 years. Early results indicate a 26 % (95 % CI 7-28 %) relative risk reduction in diabetes incidence among participants in the intensive lifestyle intervention compared to the lessintensive intervention [56]. Similarly, the Diabetes Community Lifestyle Improvement Program (D-CLIP) [57] was a RCT of diabetes prevention in adults with any form of prediabetes (IGT, impaired fasting glucose or both) comparing standard of care to a culturally tailored lifestyle education curriculum based on the DPP plus stepwise addition of metformin when needed.…”

Section: Diabetes Prevention Modelsmentioning

confidence: 99%

International Models of Care that Address the Growing Diabetes Prevalence in Developing Countries

et al. 2016

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Diabetes care involves a complex interaction between patients, physicians, the health care system, and society. In low- and middle-income countries (LMICs), where the majority of individuals with diabetes live, there is a shortage of resources and infrastructure for diabetes care. Translation of proven interventions for diabetes prevention and care from experimental settings to the real world is a major challenge, and there is limited evidence from LMICs. To curtail the diabetes burden in LMICs, it is crucial to develop and execute innovative diabetes care models that improve access to care, knowledge, and outcomes. Additionally, adequate training of local health professionals and community engagement can help LMICs become self-sufficient in delivery of diabetes care. In this paper, we reviewed the existing models of diabetes care and prevention in LMICs and provided recommendations to guide the development of a comprehensive and effective future model for diabetes care in LMICs.

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Op49 a Low Cost Primary Prevention Tool: Effects of Non Pharmacological Lifestyle Modification in Prevention of Type 2 Diabetes Mellitus in Young Urban Sri Lankan – “Diabrisk-Sl”

Cited by 2 publications

References 0 publications

High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population

High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population

International Models of Care that Address the Growing Diabetes Prevalence in Developing Countries

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