Abstract:Objectives: Soluble endoglin (sEng) is dramatically increased in preeclampsia (PE) and acts synergistically with sFlt1 to promote the pre-eclamptic phenotype. The aim of this study was to investigate, whether the sEng increase is already present in second-trimester pregnancies with abnormal perfusion and therefore at risk for PE. Methods: This prospective study included 77 second-trimester pregnant women with abnormal uterine perfusion. sEng and sFlt1 were measured using an ELISA. Results: Adverse pregnancy ou… Show more
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