OP1-3 Pandemic (H1N1) 2009 virus infections in Turkey

Cıblak, Meral A.; Albayrak, Nurhan; Odabas, Y.; Altaş, Ayşe Başak; Kanturvardar, Melis; Sucaklı, Mustafa Bahadır; Korukluoğlu, Gülay; Bal, Esra; Ertek, Mustafa

doi:10.1016/s1386-6532(09)70037-x

Cited by 2 publications

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“…All available data regarding demographic, epidemiological, and clinical parameters were sent to the reference laboratory, together with the clinical specimens. So far, there have been only two published studies reflecting the epidemiological and molecular characteristics of influenza A(H1N1)pdm virus infections in our country (5,6). Therefore, in the present study, we aimed to monitor mutations in the receptor binding region of the hemagglutinin (HA) gene, and investigate oseltamivir resistance-related mutations in the neuraminidase (NA) gene in 16 influenza A(H1N1)pdm09 viral isolates circulating in Turkey during the 2010-2011 influenza season.…”

Section: Introductionmentioning

confidence: 99%

Monitoring Genetic Diversity of Influenza A(H1N1)pdm09 Virus Circulating during the Post-Pandemic Period in Turkey

Güldemir¹,

Kalaycioglu²,

Altaş³

et al. 2013

Jpn J Infect Dis

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SUMMARY:The aimes of the present study were to monitor genetic alterations in the hemagglutin (HA) gene and oseltamivir resistance-related alterations in the neuraminidase (NA) gene of influenza A(H1N1)pdm09 viral isolates detected during the post-pandemic period in Turkey. A total of 2601 clinical specimens obtained from suspected cases of influenza A(H1N1)pdm09 viral infections were analyzed by real-time reverse transcription polymerase chain reaction. Viral RNA was detected in 233 (9z) clinical specimens. Sequence analysis of the HA gene in 16 random isolates showed À98.7z homology among each other and with the A/California/07/2009 vaccine strain. These 16 isolates had common (75z-100z) amino acid substitiutions at positions P83S, D97N, S203T, R205K, I216V, V249L, I321V, and E374K in the HA gene. In addition, two additional rare mutations were also observed at positions S162N (addition of a glycosylation site, 6.25z) and A186T (receptor binding region, 6.25z). On the basis of amino acid substitutions in the HA1 domain, majority of the Turkish isolates were classified in the genetic group v and others in the genetic groups ii, iii, and vi. In the present study, we observed an increase in the variety and ratio of mutations detected in the HA1 and HA2 domains of the HA gene; however, these alterations have not yet resulted in vaccine escape mutants in Turkey. In addition, analysis of the NA regions of the isolates revealed that oseltamivir resistance was not an issue in Turkey.

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Section: Introductionmentioning

confidence: 99%

Monitoring Genetic Diversity of Influenza A(H1N1)pdm09 Virus Circulating during the Post-Pandemic Period in Turkey

Güldemir¹,

Kalaycioglu²,

Altaş³

et al. 2013

Jpn J Infect Dis

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“…Information on clinical features and risk factors for severity among patients with novel H1N1 virus infection are still emerging. In contrast to seasonal influenza, in which adults with underlying diseases appear to be at high risk of severe illness and deaths [9,10] , novel H1N1 influenza mostly occurred in younger individuals, including pregnant women. In the beginning of the pandemic, all novel H1N1 influenza patients were hospitalized in local infectious disease hospitals in China.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and Clinical Features of 308 Hospitalized Patients with Novel 2009 Influenza A (H1N1) Virus Infection in China during the First Pandemic Wave

Zhang

Zhang²,

Liu³

et al. 2010

Intervirology

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Objectives: To investigate the epidemiological and clinical features of 308 hospitalized patients suffering from infection with novel H1N1 influenza virus in China from May to August 2009, and to examine the effects of oseltamivir treatment for mild cases. Methods: Information on H1N1 influenza patients confirmed by real-time RT-PCR assay was gathered and analyzed from an influenza surveillance system, including demographic features, clinical symptoms and signs, therapeutic regimen, and duration of fever and virus shedding. Results: The clinical course of infected individuals appeared mild. Mainly young adults were affected. Most cases had low or mid-level fever, cough, headache, rhinorrhoea, and sore throat. Few patients had vomiting (1.3%) and diarrhea (3.9%). Oseltamivir treatment did not shorten the duration of fever. Furthermore, early oseltamivir treatment as well as early conventional supportive treatment without antiviral drugs contributed to a reduction in the duration of virus shedding. Conclusions: In the first pandemic wave, novel H1N1 virus caused disease primarily in adults, causing mild febrile illness. Mildly ill patients cleared the virus rapidly even in the absence of oseltamivir treatment.

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OP1-3 Pandemic (H1N1) 2009 virus infections in Turkey

Cited by 2 publications

References 0 publications

Monitoring Genetic Diversity of Influenza A(H1N1)pdm09 Virus Circulating during the Post-Pandemic Period in Turkey

Monitoring Genetic Diversity of Influenza A(H1N1)pdm09 Virus Circulating during the Post-Pandemic Period in Turkey

Epidemiological and Clinical Features of 308 Hospitalized Patients with Novel 2009 Influenza A (H1N1) Virus Infection in China during the First Pandemic Wave

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