Op0276 dendritic Cell-Derived Il-27 Regulates the Magnitude of Inducible Ectopic Germinal Centres but Fails to Downmodulate Il-17 Production in Cd4 T Cells From Patients With Sjögren’s Syndrome
Abstract:BackgroundApproximately 30% of Sjögren’s Syndrome (SS) patients develop Ectopic Lymphoid Structures (ELS) in their salivary glands (SG). ELS play an active role in autoimmunity and contribute to the development of MALT lymphoma. Interleukin 27 (IL-27) exerts key immunomodulatory actions on CD4 T cells with both pro and anti-inflammatory roles but its role in the formation and regulation of ELS in the salivary glands of SS is unknown.ObjectivesWe first used a murine model of inducible SG ELS to elucidate the ro… Show more
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