Abstract:BackgroundTumor necrosis factor (TNF)-a, a potent pro-inflammatory cytokine, is generated in a precursor form called transmembrane (m)TNF-a that is expressed on the surface TNF-a producing cells. TNF-a was shown to act both as a ligand by binding to TNF-a receptors, as well as a receptor that transmits outside-to-inside (reverse) signals back into the mTNF-a bearing cells. Anti-TNF-a targeting molecules which neutralize TNF-a with the same efficiency show disease specific effectiveness.ObjectivesThe aim of the… Show more
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