OP0184 High Resolution Micro-Computerized Tomography Imaging as a Translational Tool to Quantitatively Assess Bone Damage in a Mouse Model of Collagen-Induced Arthritis in Mice: Disease Severity and Time-Course of Bone Changes
Abstract:Background
HR micro-CT is a powerful imaging tool to visualize and quantify the degree of bone damage in the preclinical and clinical setting, thus making it a highly translatable tool. Unlike flat-film radiography, CT imaging allows one to generate a 3-D reconstruction of the diseased joint providing one unparalleled images
Objectives
1) apply HR micro-CT imaging to the knee and ankle joints in a murine CIA model, 2) develop novel image analysis techniques to objectively quantify the degree of bone damage, … Show more
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