Abstract:BackgroundRheumatoid arthritis (RA) is a common chronic inflammatory disease of the joints. Whilst the autoimmune element continues to be studied intensely, it is evident that the innate inflammatory response propagates the disease. Fibroblast-like synoviocytes (FLS) are the most abundant stromal cell in the synovium. FLS from RA joints are markedly different from their healthy counterparts in their inflammatory characteristics.RA FLS exhibit a form of inflammatory memory named priming. Prolonged exposure to T… Show more
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