OP014 [Healthcare systems » Healthcare systems]: ADAPTING A PICU FOR ADULT PATIENTS DURING A PANDEMIC: IMPACTS AND LEARNING FROM INTERPROFESSIONAL CARE OF CRITICALLY ILL ADULTS WITH COVID-19

Abstract

BACKGROUND AND AIM:To determine whether the intravenous administration of Thiamine, Vitamin C, and Vitamin B12 in patients with septic shock leads to a more rapid resolution of septic shock and reduces the mortality compared to standard care alone METHOD: Patients were randomised to the intervention group (n = 59), consisting of intravenous thiamine (100 mg every 12 hours), vitamin C (every 6 hours), Vitamin B12(every 24hours) and to the control group (n = 61), consisting of standard treatment alone till 3days. The primary trial outcome was ICU mortality and 28day vasopressor free days. 8 secondary outcomes were prespecified, including change in SOFA score and lactate on day3.RESULTS: Among 267 patients who were eligible for the study, 147 patients were excluded, and 120 patients were randomized. 28-day vasopressor-free days were a median of 27 days (IQR, 25-27 days) in the intervention group and 26 days (IQR, 0-27 days) in the control group, with a median difference of −1day (P =.85). ICU mortality was 16/69(27.1%) in intervention group and 22/61(36.1%) in control group value (p 0.292). Change in SOFA on Day 3 was 3 with IQR (1 to 4) in the intervention group and 2 with IQR (1 to 4) in control group (P 0.019). CONCLUSIONS:In children with severe sepsis and septic shock, treatment with intravenous Thiamine, vitamin C, and vitamin B12, compared with standard treatment alone, did not significantly improve the ICU mortality and 28day vasopressor free days.