OP01.01: Second trimester growth restriction and underlying fetal anomalies

Vanlieferinghen, Sarah; Bernard, Jean‐Pierre; Salomon, Laurent; Chalouhi, G. E.; Russell, Nóirín; Ville, Y.

doi:10.1002/uog.11389

Cited by 10 publications

(17 citation statements)

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“…Kappa coefficient for comparison of interrater reliability was 0.92 during the title and abstract search stage (95% CI 0.88 to 0.97) and 0.92 at full‐text evaluation (95% CI 0.81 to 1.0). Finally, 14 references comprising 874 cases of apparently isolated IUGR on ultrasound examination were included in the review . Two authors were contacted for data clarification, mainly to inquire about the timing of sonographic diagnosis and type of data acquisition (eg, retrospective); however, no reply was received.…”

Section: Resultsmentioning

confidence: 99%

“…All articles were conducted in observational cohort design, including 1 manuscript with prospective data acquisition . Eleven studies were issued in English, 1 paper in Chinese, 1 in French, and 1 in Bosnian language. Inclusion criteria extensively differed between the manuscripts (Table SS2).…”

Section: Resultsmentioning

confidence: 99%

“…Eleven studies did not mention any information related to dating procedure (Table SS3). Two papers required reliable gestational ages from maternal menstrual history and US examinations in early pregnancy, while 1 study relied only on crown‐rump length measurement in the first trimester …”

Section: Resultsmentioning

confidence: 99%

“…Only 8 papers mentioned maternal age factor, all of them including women above the age of 35 years, and a single study included only pregnancies with low risk for chromosomal abnormalities, requiring a normal first‐trimester scan and a low risk of fetal aneuploidy by nuchal translucency and/or maternal serum screening . As to independent risk factors for IUGR—5 investigations excluded multiple pregnancies, 2 referred to intrauterine infections as possible etiology for IUGR, and none of the studies examined maternal diseases, malnutrition, or substance use during pregnancy.…”

Section: Resultsmentioning

confidence: 99%

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Risk for chromosomal aberrations in apparently isolated intrauterine growth restriction: A systematic review

2017

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Risk for chromosomal aberrations in apparently isolated intrauterine growth restriction: A systematic review

2017

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“…Gestational age at diagnosis and resolution of CMA were not reported. Vanlieferinghen et al (2014) strengthened these results in the largest cohort including 135 isolated FGR. The chromosomal anomaly rate was 9.6% (5/52) in very early onset FGR (below 24 weeks) and 9.3% (7/75) in late FGR, and CMA showed a 5.5% incremental yield compared with karyotyping.…”

Section: Submicroscopic Chromosomal Anomaliesmentioning

confidence: 92%

Genetic syndromes associated with isolated fetal growth restriction

2020

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Early onset fetal growth restriction (FGR) may be due to impaired placentation, environmental or toxic exposure, congenital infections or genetic abnormalities. Remarkable research, mainly based on retrospective series, has been published on the diverse genetic causes. Those have become more and more relevant with the improvement in the accuracy of the analysis techniques and the rising of breakthrough genomewide methods such as the whole genome sequencing. However, no publication has presented an integrated view of management of those fetuses with an early and severe affection. In this review, we explored to which extent genetic syndromes can cause FGR fetuses without structural defects. The most common chromosomal abnormalities (Triploidies and Trisomy 18), submicroscopic chromosomal anomalies (22q11.2 microduplication syndrome) and single gene disorders (often associated with mild ultrasound findings) related to early and severe FGR had been analysed. Finally, we addressed the impact of epigenetic marks on fetal growth, a matter of growing importance. At the end of this review, we should be able to provide an adequate counseling to parents in terms of diagnosis, prognosis and management of those pregnancies.

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Prenatal diagnosis of fetal growth restriction with polyhydramnios, etiology and impact on postnatal outcome

Walter

Calite

Berg

et al. 2022

Sci Rep

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To assess the spectrum of different etiologies, the intrauterine course, outcome and possible prognostic markers in prenatally detected fetal growth restriction (FGR) combined with polyhydramnios. Retrospective study of 153 cases with FGR combined with Polyhydramnios diagnosed by prenatal ultrasound over a period of 17 years. Charts were reviewed for ultrasound findings, prenatal and postnatal outcome. All cases were categorized into etiological groups and examined for differences. Five etiological groups were identified: chromosomal anomalies (n = 64, 41.8%), complex malformation syndromes (n = 37, 24.1%), isolated malformations (n = 24, 15.7%), musculoskeletal disorders (n = 14, 9.2%) and prenatal non-anomalous fetuses (n = 14, 9.2%). Subgroups showed significant disparities in initial diagnosis of combination of both pathologies, Ratio AFI/ gestational weeks and Doppler ultrasound examinations. Overall mortality rate was 64.7%. Fetuses prenatally assigned to be non-anomalous, showed further complications in 42.9% (n = 6). Fetuses prenatally diagnosed with FGR combined with polyhydramnios are affected by a high morbidity and mortality. Five etiologic groups can be differentiated, showing significant disparities in prenatal and postnatal outcome. Even without recognizable patterns prenatally, long-term-follow up is necessary, as neurodevelopmental or growth delay may occur.

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OP01.01: Second trimester growth restriction and underlying fetal anomalies

Cited by 10 publications

References 0 publications

Risk for chromosomal aberrations in apparently isolated intrauterine growth restriction: A systematic review

Risk for chromosomal aberrations in apparently isolated intrauterine growth restriction: A systematic review

Genetic syndromes associated with isolated fetal growth restriction

Prenatal diagnosis of fetal growth restriction with polyhydramnios, etiology and impact on postnatal outcome

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