OP0044 Abatacept Reduces CD4 Positive T-Cells in Psoriatic Arthritis Synovial Tissue; Preliminary Analysis from a Single Centre, Placebo-Controlled, Crossover Study
Abstract:BackgroundAbatacept is a fully human fusion protein which selectively inhibits T-cell activation via the CD80/CD86:CD28 co-stimulation pathway and decreases serum levels of inflammatory cytokines and proteins implicated in the pathogenesis of psoriatic arthritis (PsA). Improvement in skin psoriasis with greatest reduction in PASI using 3 mg/kg dose of abatacept and reduction of clinical symptoms of PsA on 10 mg/kg dose has been previously shown. Data is limited on the immunopathological effect of abatacept in … Show more
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