OP004 [Lung » Airway disease and related issues]: IMPACT OF AGE AND AIRWAY RESISTANCE ON THE RELIABILITY OF PEAK INSPIRATORY PRESSURE TO ESTIMATE PLATEAU PRESSURE IN CHILDREN

Abstract

BACKGROUND AND AIM: Vascular hyperpermeability by loss of endothelial barrier integrity is a hallmark of sepsis. Vimentin is involved in regulation of endothelial function and inflammatory response. However, the serum level of Vimentin and its clinical relevance in pediatric severe sepsis (PSS) is remain unknown. METHOD:We conducted a prospective study in PSS admitted to the pediatric intensive care units (PICU) from January 2018 to December 2020. RESULTS:A total of 108 PSS median aged of 19.5 month were enrolled. The hospital mortality rate was 19.44% (21/108). Comparing with healthy control, serum Vimentin levels on PICU admission were significantly higher in PSS (P < 0.001). The area under ROC curve (AUC) for Vimentin to predict the hospital mortality was 0.712 (95% CI: 0.578 -0.846) with a sensitivity of 71.43 % and a specificity of 70.11 %. Moreover, hospital mortality was significantly higher in the group of patients with Vimentin level over 24.53 ng/mL than that in patients with Vimentin level below 24.53 ng/ml (P < 0.001).CONCLUSIONS: Serum Vimentin level as an indicator of endothelial injury is associated with the prognosis of PSS, and serum Vimentin level ≥24.53 ng/ml on PICU admission predicts high risk of hospital mortality in PSS.