OP-1206, a Prostaglandin E1 Derivative, Attenuates the Thermal Hyperesthesia Induced by Constriction Injury to the Sciatic Nerve in the Rat

Yamamoto, Takatsugu; Shimoyama, Naohito; Asano, Hidefumi; Mizuguchi, Tadanobu

doi:10.1213/00000539-199503000-00014

Anesthesia & Analgesia

1995

DOI: 10.1213/00000539-199503000-00014

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OP-1206, a Prostaglandin E1 Derivative, Attenuates the Thermal Hyperesthesia Induced by Constriction Injury to the Sciatic Nerve in the Rat

Takatsugu Yamamoto

Naohito Shimoyama

Hidefumi Asano

et al.

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Cited by 2 publications

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“…The findings raise the possibility that the increase of nerve blood flow alleviates pain induced by chemotherapeutic agents. In this context, limaprost, an orally active prostaglandin E 1 analog, suppresses pain-associated claudication induced by spinal stenosis (7) and thermal hyperesthesia induced by constriction injury to the sciatic nerve in rats (8). In the present study, therefore, we tested the effects of limaprost on mechanical allodynia after administration of paclitaxel, oxaliplatin, and vincristine.…”

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Effects of the Prostaglandin E1 Analog Limaprost on Mechanical Allodynia Caused by Chemotherapeutic Agents in Mice

et al. 2009

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Abstract. This study examined in mice whether limaprost, a prostaglandin E 1 analog, would relieve allodynia induced by chemotherapeutic agents. Single intraperitoneal injections of paclitaxel, oxaliplatin, and vincristine sulfate induced and gradually increased mechanical allodynia. Repeated administration of limaprost alfadex inhibited the late, but not early, phase of mechanical allodynia induced by paclitaxel and oxaliplatin, but not vincristine. Paclitaxel and oxaliplatin, but not vincristine, gradually decreased peripheral blood flow, which was prevented by limaprost. These results suggest that limaprost is effective against mechanical allodynia induced by paclitaxel and oxaliplatin, which may be due to inhibition of the decrease in peripheral blood flow.

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Effects of the Prostaglandin E1 Analog Limaprost on Mechanical Allodynia Caused by Chemotherapeutic Agents in Mice

et al. 2009

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Comparisons between the efficacy of limaprost alfadex and pregabalin in cervical spondylotic radiculopathy : design of a randomized controlled trial

Onda

Kimura

2018

FJMS

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Background : Cervical spondylotic radiculopathy (CSR) is a relatively common neurological disease caused by the mechanical compression of nerve roots. Limaprost, a prostaglandin E 1 derivative, functions as a vasodilator and has been used in the treatment of lumbar spinal stenosis in Japan. However, the effects of limaprost in cervical radiculopathy remain unclear. Our aim was to compare the efficacy of limaprost with that of pregabalin, which is widely used for the treatment of neuropathic pain. Methods : In this randomized trial, patients with CSR received either limaprost or pregabalin orally for 8 weeks, along with nonsteroidal anti -inflammatory drugs. The primary outcomes were assessed using a numerical rating scale of pain and numbness, both at rest and during movement. Secondary outcomes were assessed using Short Form -36, provocation tests, painDETECT questionnaire, and subjective global assessment. The obtained data were evaluated according to the per -protocol analysis principle. Results : A total of 46 patients were enrolled in this study, and 35 were available for analysis. A greater reduction in pain score was observed in neck pain during movement, and scapular and arm pain both at rest and during movement in the pregabalin -treated group up to 4 weeks. In the limaprost -treated group, numbness of the arm during movement showed a marked alleviation compared to the pregabalin -treated group at 8 weeks. There were no apparent differences between the two groups in terms of the secondary outcomes. Conclusions : Although pregabalin provided an earlier pain relief than limaprost, limaprost was superior to pregabalin in treating arm numbness. Limaprost might be one of the effective therapeutic options for CSR in primary care settings.

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OP-1206, a Prostaglandin E1 Derivative, Attenuates the Thermal Hyperesthesia Induced by Constriction Injury to the Sciatic Nerve in the Rat

Cited by 2 publications

References 18 publications

Effects of the Prostaglandin E1 Analog Limaprost on Mechanical Allodynia Caused by Chemotherapeutic Agents in Mice

Effects of the Prostaglandin E1 Analog Limaprost on Mechanical Allodynia Caused by Chemotherapeutic Agents in Mice

Comparisons between the efficacy of limaprost alfadex and pregabalin in cervical spondylotic radiculopathy : design of a randomized controlled trial

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