Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe Akkermansia muciniphila and modulating glutamine metabolism

Wang, Jue; Guo, Xiaozhen; Zou, Ziyuan; Yu, Minjun; Li, Xueling; Xu, Hualing; Chen, Yiping; Jiao, Tingying; Wang, Kanglong; Ma, Yuandi; Jiang, Jie; Liang, Xinyu; Wang, Jiawen; Xie, Cen; Zhong, Yifei

doi:10.1016/j.biopha.2023.115434

Cited by 4 publications

(2 citation statements)

References 63 publications

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“…Disruption of the gut microbiota balance and the presence of metabolites derived from dysbiosis can lead to renal injury, ultimately resulting in renal fibrosis. [46–48] Various intestinal microorganisms, gut-derived metabolites, and cellular components penetrate the gut barrier and enter the bloodstream. These toxic metabolites reach the kidneys, interacting with immune cells and initiating inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric Analysis of the Relationship between Gut Microbiota and Chronic Kidney Disease from 2001–2022

Tao,

Huo,

Chen

2024

Integr Med Nephrol Androl

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Background: The gut microbiota is closely associated with chronic kidney disease (CKD) development and prognosis. However, a comprehensive understanding of publication trends and research focuses within this domain remains limited. This study aimed to elucidate the relationship between the gut microbiota and CKD through a bibliometric analysis. Methods: Literature published between 2001 and 2022 on gut microbiota and CKD was obtained from the Web of Science Core Collection database. Bibliometric analysis tools such as VOSviewer and CiteSpace were used to analyze research trends in this area. Results: We extracted 758 articles for further analysis. China ranked first with 240 published documents, followed by the USA with 211. However, the USA ranked first regarding citation frequency with 11,380 citations, while China ranked second. The University of California Irvine and Kidney International emerged as the leading institution and journal, respectively, with the former leading in document production and citations. Although Kidney International featured fewer documents than other journals, it exhibited the highest citation count. The keywords representing the research interests mainly included: (1) gut microbiota influences the development of CKD, (2) application of probiotics in the treatment of CKD, and (3) potential mechanism of gut microbiota in CKD. Conclusion: Our analysis indicates significant advancements in understanding the association between gut microbiota and CKD. It also provides a comprehensive overview of publication trends, research hotspots, and frontiers, which may provide guidelines for future research.

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Section: Discussionmentioning

confidence: 99%

Bibliometric Analysis of the Relationship between Gut Microbiota and Chronic Kidney Disease from 2001–2022

Tao,

Huo,

Chen

2024

Integr Med Nephrol Androl

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“…Andrographolide prevents type 2 diabetes by modifying the gut microbiota composition, elevating the Bacteroidetes/Firmicutes ratio, enriching microbial species such as A. muciniphila, and increasing the short-chain fatty acid concentration (Su et al, 2020). Ootheca mantidis, a commonly prescribed herbal medicine for chronic kidney disease, mitigates renal fibrosis in mice by modulating glutamine metabolism, remodeling the gut microbiota, increasing the levels of some probiotics (including A. muciniphila), and downregulating apoptosis and inflammation-associated pathways (Wang et al, 2023). Dysbiosis of the gut microbiome and related metabolites has been intimately associated with disease.…”

Section: Adjusted Microbiomementioning

confidence: 99%

Akkermansia muciniphila and herbal medicine in immune-related diseases: current evidence and future perspectives

Ding,

Meng,

et al. 2024

Front. Microbiomes

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Akkermansia muciniphila is considered the “paradigm for next-generation beneficial microorganisms” and has been reported to help alleviat immune-related diseases. Evidence shows that herbal medicine can treat disease by regulating the abundance of A. muciniphila. Recent studies have revealed a link between A. muciniphila and immune-related diseases. Here, we systematically reviewed the association between A. muciniphila, herbal medicine, and immune-related diseases (including inflammatory bowel disease, human immunodeficiency virus, cancer immunotherapy, and immune-related liver injury). We also summarize the potential mechanisms of action of A. muciniphila and offer perspectives for future studies.

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From ancient wisdom to modern science: Gut microbiota sheds light on property theory of traditional Chinese medicine

Yang,

Zhan,

Cao

et al. 2024

Journal of Integrative Medicine

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Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe Akkermansia muciniphila and modulating glutamine metabolism

Cited by 4 publications

References 63 publications

Bibliometric Analysis of the Relationship between Gut Microbiota and Chronic Kidney Disease from 2001–2022

Bibliometric Analysis of the Relationship between Gut Microbiota and Chronic Kidney Disease from 2001–2022

Akkermansia muciniphila and herbal medicine in immune-related diseases: current evidence and future perspectives

From ancient wisdom to modern science: Gut microbiota sheds light on property theory of traditional Chinese medicine

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