Abstract:Increasing astrocyte glutamate uptake is protective in a model of epilepsy Peterson, Allison R., et al. Targeted overexpression of glutamate transporter-1 reduces seizures and attenuates pathological changes in a mouse model of epilepsy. Neurobiology of Disease, 2021. P157.Astrocytic glutamate transporters are crucial for glutamate homeostasis in the brain, and dysregulation of these transporters can contribute to the development of epilepsy. Glutamate transporter-1 (GLT-1) is responsible for the majority of g… Show more
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