“…When the role of local factors is considered as influential to bone formation rate to any significant degree, then it is appropriate to employ tissue from a model taken from sites where there are loading dynamics not dissimilar to the human. In this regard, the NHP is superior to other models such as the rat [Danielsen et al, 1992;Jee et al, 1990;Kalu, 1991] and the dog [Faugere et al, 1990;Snow et al, 1984], which have significant shortcomings in terms of biomechanics, growth properties, endocrinology, and cortical bone tissue morphology. The femoral neck of the NHP has the basic triangular shape of the human, with variation in cortical thickness [Hotchkiss, 1999], as opposed to the round shape with uniform cortical thickness seen in rats [Bagi et al, 1997].…”