Oocyte–somatic cell–endocrine interactions in pigs

Hunter, M. G.; Brankin, Victoria; Quinn, Ruth L.; Ferguson, Elizabeth M.; Edwards, Sandra A.; Ashworth, Cheryl

doi:10.1016/j.domaniend.2005.02.004

Cited by 21 publications

(11 citation statements)

References 67 publications

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“…The quality of the oocyte is largely dependent on its follicular environment, as shown in a number of animal and human studies [4,13]. During ovarian stimulation and ovulation induction, a cohort of heterogeneous follicles is recruited to develop and ovulate, irrespective of their differentiative state.…”

Section: Introductionmentioning

confidence: 99%

Mural granulosa cell gene expression associated with oocyte developmental competence

et al. 2010

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BackgroundOvarian follicle development is a complex process. Paracrine interactions between somatic and germ cells are critical for normal follicular development and oocyte maturation. Studies have suggested that the health and function of the granulosa and cumulus cells may be reflective of the health status of the enclosed oocyte. The objective of the present study is to assess, using an in vivo immature rat model, gene expression profile in granulosa cells, which may be linked to the developmental competence of the oocyte. We hypothesized that expression of specific genes in granulosa cells may be correlated with the developmental competence of the oocyte.MethodsImmature rats were injected with eCG and 24 h thereafter with anti-eCG antibody to induce follicular atresia or with pre-immune serum to stimulate follicle development. A high percentage (30-50%, normal developmental competence, NDC) of oocytes from eCG/pre-immune serum group developed to term after embryo transfer compared to those from eCG/anti-eCG (0%, poor developmental competence, PDC). Gene expression profiles of mural granulosa cells from the above oocyte-collected follicles were assessed by Affymetrix rat whole genome array.ResultsThe result showed that twelve genes were up-regulated, while one gene was down-regulated more than 1.5 folds in the NDC group compared with those in the PDC group. Gene ontology classification showed that the up-regulated genes included lysyl oxidase (Lox) and nerve growth factor receptor associated protein 1 (Ngfrap1), which are important in the regulation of protein-lysine 6-oxidase activity, and in apoptosis induction, respectively. The down-regulated genes included glycoprotein-4-beta galactosyltransferase 2 (Ggbt2), which is involved in the regulation of extracellular matrix organization and biogenesis.ConclusionsThe data in the present study demonstrate a close association between specific gene expression in mural granulosa cells and the developmental competence of oocytes. This finding suggests that the most differentially expressed gene, lysyl oxidase, may be a candidate biomarker of oocyte health and useful for the selection of good quality oocytes for assisted reproduction.

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Section: Introductionmentioning

confidence: 99%

Mural granulosa cell gene expression associated with oocyte developmental competence

et al. 2010

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“…Recently, communications and interactions between the oocyte and the surrounding follicular cells have received attention (Amleh and Dean, 2002;Matzuk et al, 2002;Gilchrist et al, 2004;Hunter et al, 2005). Although their assembly processes and corresponding interactions are strikingly similar in diverse organisms, the underlying molecular mechanisms remain enigmatic as commented by Matova and Cooley (2001).…”

Section: Discussionmentioning

confidence: 99%

Identification of a novel C2 domain factor in ovaries of orange-spotted grouper (Epinephelus coioides)

Ji¹,

Zhou²,

Wang³

et al. 2006

Comparative Biochemistry and Physiology Part B: Biochemistry an

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“…Further activity of these processes is shaped by the increase in estradiol levels, inhibin or the formation of an appropriate number of receptors for lutropin (LH) in granulosa cells [31]. According to Hunter et al ,the minimum diameter of the vesicles in which the LH receptors were found is 5 mm [32].…”

Section: Physiological Basis Of Folliculogenesis In Mammalsmentioning

confidence: 99%

“…The control of granulosa cell function by the oocyte takes place on the basis of feedback between both cell types. The gamete-somatic cell relation affects both the development of oocyte and ovarian follicles [19], [32].…”

Section: Factors Influencing Follicular Steroidogenesismentioning

confidence: 99%

Characteristic of factors influencing the proper course of folliculogenesis in mammals

Rybska

Knap

Jankowski

et al. 2018

Medical Journal of Cell Biology

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Folliculogenesis is the process of ovarian follicle formation,, taking presence during foetal period. During the follicular development, oogoniums undergo meiosis and oocytes are formed. In the ovaries of new born sows, primary and secondary follicles are present and, 90 days after birth, tertiary follicles appear. During development in the ovarian follicles growth of granulosa cells and differentiation of the thecal cells can be observed. A cavity filled with follicular fluid appears. Granulosa cells are divided into: mural cells and corona radiata, which together with the oocyte form the cumulus oophorus. Corona radiata cells, mural layers and oolemma contact each other by a network of gap junctions. Secreted from the pituitary gland, FSH and LH gonadotropin hormones act on receptors located in granular and follicular cells. In the postnatal life tertiary follicles and Graafian follicles are formed. When the follicle reaches a diameter of 1 mm, further growth depends on the secretion of gonadotropins. Mature ovarian follicles produce: progestins, androgens and oestrogens. The growth, differentiation and steroidogenic activity of ovarian follicles, in addition to FSH and LH, is also affected by prolactin, oxytocin, steroid and protein hormones, numerous proteins from the cytokine and interleukin family, metabolic hormones like insulin, glucocorticoids, leptin, thyroid hormones and growth hormones. Despite numerous studies, many processes related to folliculogenesis have not been discovered Learning the mechanisms regulating reproductive processes would allow to easily distinguish pathological processes and discover more and more genes and mechanisms of their expression in cells that build ovarian follicles. Running title: regulation of folliculogenesis

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Oocyte–somatic cell–endocrine interactions in pigs

Cited by 21 publications

References 67 publications

Mural granulosa cell gene expression associated with oocyte developmental competence

Mural granulosa cell gene expression associated with oocyte developmental competence

Identification of a novel C2 domain factor in ovaries of orange-spotted grouper (Epinephelus coioides)

Characteristic of factors influencing the proper course of folliculogenesis in mammals

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