Oocyte slow freezing using a 0.2–0.3 M sucrose concentration protocol: is it really the time to trash the cryopreservation machine?

Bianchi, Veronica; Lappi, Michela; Bonu, Maria Antonietta; Borini, Andrea

doi:10.1016/j.fertnstert.2012.01.127

Cited by 41 publications

(24 citation statements)

References 40 publications

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“…Similar results in experienced hands have been documented after oocytes cryopreservation [35,36]. Few data are available on the pregnancy rates after oocyte or embryo cryopreservation in patients with breast cancer [37] and only two live births have been reported in women banking oocytes or embryos prior to ovarian cancer treatment [38,39].…”

Section: Key Pointssupporting

confidence: 61%

Update on fertility preservation in young women undergoing breast cancer and ovarian cancer therapy

Lambertini

Ginsburg

Partridge

2015

Current Opinion in Obstetrics &Amp; Gynecology

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Embryo cryopreservation is widely available with a highly successful track record. Improvements in laboratory techniques have led to oocyte cryopreservation recently being recategorized as nonexperimental. Conservative gynecologic surgery is a standard consideration for patients with stage I ovarian cancer who desire future fertility. Ovarian tissue cryopreservation as well as ovarian suppression with luteinizing hormone-releasing hormone analogs during chemotherapy are considered experimental methods at this time, although recent data suggest both safety and efficacy for the use of luteinizing hormone-releasing hormone analogs in women receiving (neo)adjuvant chemotherapy for breast cancer. Special issues should be considered for women with BRCA mutations because of the need to undergo preventive surgery at young age. Multidisciplinary teams and well functioning relationships between the oncology and reproductive units are crucial to manage the fertility issues of young women with cancer.

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Section: Key Pointssupporting

confidence: 61%

Update on fertility preservation in young women undergoing breast cancer and ovarian cancer therapy

Lambertini

Ginsburg

Partridge

2015

Current Opinion in Obstetrics &Amp; Gynecology

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“…Using this procedure, the live birth rates according to the 2012 European Society of Human Reproduction and Embryology (ESHRE) were 22.7% for patients younger than 34 years, 18.1% for women aged 35-39, and less than 10% for women older than 40 years 38 . In experienced centers, similar results can be obtained after oocyte cryopreservation 39,40 .…”

Section: Letrozole-associated Controlled Ovarian Hyperstimulationsupporting

confidence: 66%

Viable Options for Fertility Preservation in Breast Cancer Patients: A Focus on Latin America

Lambertini

Goldrat

Barragán-Carrillo

et al. 2017

RIC

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Thanks to the improved survival outcomes observed in recent years, a growing attention has been given to the quality of life issues faced by young women with breast cancer such as fertility preservation and concerns related to future pregnancies.However, several challenges remain for young women with breast cancer considering undergoing fertility preservation strategies.Further specific issues on this regard should be taken into account in Latin America, where patients and physicians face particular barriers that hinder the routine adoption of this practice. Hence, further efforts are needed to overcome these deficiencies and improve the correct referral of breast cancer patients to fertility preservation strategies.The aim of the present review is to focus on the risk of anticancer treatment-related premature ovarian failure and infertility in young breast cancer patients, to summarize the current knowledge on the available options for fertility preservation, and to discuss the safety issues of pregnancy in breast cancer survivors. Furthermore, this review aims to highlight the specific clinical challenges in this field encountered by healthcare providers and young breast cancer patients from Latin American countries. (REV INVES CLIN. 2017;69:103-13)

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“…Furthermore, even though we showed that VF results in significantly higher success rates compared to SF, the latter protocol is still undergoing evolution, and its efficiency may catch up with VF. Recently, Bianchi et al reported higher success rates using a modified SF protocol showing that future studies are likely to have enhanced success with SF (41). This feature will be accounted in newer or updated models as more data will be available.…”

Section: Discussionmentioning

confidence: 99%

Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis

Cıl

Bang

Oktay

2013

Fertility and Sterility

162

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Objective To estimate age-specific probabilities of live-birth with oocyte cryopreservation in non-donor (ND) egg cycles. Design Individual patient data (IPD) meta-analysis. Setting Assisted reproduction centers. Patients Infertile patients undergoing ND mature oocyte cryopreservation. Interventions PubMed was searched for the clinical studies on oocyte cryopreservation from January 1996 through July 2011. Randomized and non-randomized studies that used ND frozen-thawed mature oocytes with pregnancy outcomes were included. Authors of eligible studies were contacted to obtain IPD. Main outcome measures Live-birth probabilities based on age, cryopreservation method, and the number of oocytes thawed, injected, or embryos transferred. Results Original data from 10 studies including 2265 cycles from 1805 patients were obtained. Live-birth success rates declined with age regardless of the freezing technique. Despite this age-induced compromise, live-births continued to occur as late as to the ages of 42 and 44 with slowly-frozen (SF) and vitrified (VF) oocytes, respectively. Estimated probabilities of live-birth for VF oocytes were higher than those for SF. Conclusions The live-birth probabilities we calculated would enable more accurate counseling and informed decision of infertile women who consider oocyte cryopreservation. Given the success probabilities, we suggest that policy-makers should consider oocyte freezing as an integral part of prevention and treatment of infertility.

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Oocyte slow freezing using a 0.2–0.3 M sucrose concentration protocol: is it really the time to trash the cryopreservation machine?

Cited by 41 publications

References 40 publications

Update on fertility preservation in young women undergoing breast cancer and ovarian cancer therapy

Update on fertility preservation in young women undergoing breast cancer and ovarian cancer therapy

Viable Options for Fertility Preservation in Breast Cancer Patients: A Focus on Latin America

Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis

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