Oocyte quality and treatment outcome in intracytoplasmic sperm injection cycles of polycystic ovarian syndrome patients

Ludwig, Michael; Finas, D.; Al‐Hasani, S.; Diedrich, K.; Ortmann, O.

doi:10.1093/humrep/14.2.354

Cited by 131 publications

(85 citation statements)

References 22 publications

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“…The literature contains several studies that report that oocyte maturation is impaired in PCOS (20), oocyte quality and fertilization capacities are reduced (21), and, in addition, obesity contributes to such impaired maturation in PCOS (22)(23)(24). Fedorcsák et al (9) reported that the number of oocytes retrieved was low in PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

Kalem

Sarı

et al. 2016

J Turkish German Gynecol Assoc

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Results:Variations in cycle variables with BMI and age showed that IVF cycles were negatively affected by increases in obesity and age. Clinical pregnancy rates were found to be lower in the obese group than in the other groups, particularly in the age group above 35 years; however, this difference could not be proven statistically. Conclusion:The present study evaluated obesity and clinical pregnancy rates in IVF cycles in PCOS patients according to age groups, and particularly in the obese group, the clinical pregnancy rates were observed to be lower in the age group ≥35 years than in the other BMI groups; however, this difference was found to be statistically insignificant. (J Turk Ger Gynecol Assoc 2016; 17: 83-90) Keywords: PCOS, body mass index, age, IVF outcome Received: 31 December, 2015 Accepted: 8 March, 2016 Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome Bailey et al. (12) investigated the effect of BMI on the characteristics and outcomes of IVF cycles in PCOS and found lower clinical pregnancy rates in an obese PCOS group than in a lean group and a lower rate of ovarian hyperstimulation syndrome (OHSS) in the obese group. A woman's age is also an important factor in IVF success (13,14). The IVF success rate reduces with increasing age in PCOS, as in all infertile patient groups (15, 16). The literature contains a very limited number of studies that investigate age and BMI together. Heijnen et al. (17) reported that although BMI has a significant and negative effect on female fertility, this effect gradually decreases as women approach their mid-thirties and also in younger women receiving IVF. Above the age of 36 years, on the other hand, the effect of BMI on fertility becomes minimal. PCOS patients were not included in this study. The study by Metwally et al. (8) that investigated 426 IVF/ICSI cycles did not exclude PCOS patients and reported that although obesity does not affect oocyte quality, there is a reduction in embryo quality in patients under the age of 35 years. The hypothesis of the present study assumed that the effect of BMI on the IVF cycles of PCOS patients may vary with age. The present study aimed to investigate age-related variations in the effect of BMI on IVF outcomes. Material and MethodsThis was a cohort study conducted by retrospectively investigating the IVF cycles of 653 PCOS patients under the age of 40 years, who were diagnosed based on the Rotterdam criteria in Gürgan IVF clinic between 2005 and 2015. The study protocol was approved by the local ethics committee, and all patients included in the study provided informed consent. The patients were diagnosed with PCOS in accordance with the diagnostic criteria of the European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine Rotterdam Consensus Meeting 2003 (18). Based on this set of criteria, two of the following three criteria are necessary for confirming a diagnosis: -Anovulation or Oligoovulation -Biochemical or Clinical Hyperandr...

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Section: Discussionmentioning

confidence: 99%

Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

Kalem

Sarı

et al. 2016

J Turkish German Gynecol Assoc

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“…Decreased LH concentrations result in estradiol production impairment, follicle selection derangement, inability of luteinization and ovulation after hCG administration [46]. Increased LH concentrations are believed to be responsible for poor oocytes quality, low fertilization rate and high miscarriage percentage in patients with PCOS [47,48]. Optimal concentration of LH needed to most favorable COH became the subject of many studies and discussions.…”

Section: Discussionmentioning

confidence: 99%

Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study

Kurzawa

Ciepiela

Bączkowski

et al. 2008

J Assist Reprod Genet

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Purpose Embryological and clinical efficacy of gonadotropinreleasing hormone (GnRH) antagonist and agonist stimulation protocols in non-obese women with polycystic ovarian syndrome (PCOS) were compared. Methods A prospective randomized study. Setting: Medical University Hospital. Patients: 70 infertile PCOS patients; 33 in GnRH antagonist and 37 in GnRH agonist group. Results Similar mature metaphase II oocyte rate (76% vs. 76%) was observed in both protocols. Optimal pronuclear morphology zygotes dominated in both groups (64% vs. 66%). Transferred embryo quality did not differ in both protocols. No significant differences between both protocols were found in delivery rate ( p=0.481), pregnancy rate ( p=0.810), multiple pregnancy rate ( p=0.501), miscarriage rate ( p=0.154), fertilization rate ( p=0.388) and implantation rate (p=1.000). Duration of stimulation and total follicle-stimulating hormone (FSH) dose were significantly lower in GnRH antagonist protocol ( p=0.0005). Conclusions GnRH antagonist and agonist protocols in non-obese PCOS patients yield similar embryological and clinical outcomes. Shorter duration of treatment and lower FSH requirement in GnRH antagonist group may be financially beneficial and therefore attractive for patients.

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“…The reproductive performance of women undergoing IVF treatment with PCOS is characterized by their good response to ovarian stimulation that yields higher number of oocytes; however, with lower implantation and higher miscarriage rates (Engmann et al 1999, Ludwig et al 1999, Mulders et al 2003. Individual oocytes retrieved from nine women with PCOS and that from ten non-hirsute ovulatory women are used for microarray hybridization (Wood et al 2007).…”

Section: Global Gene Expression Changes During Loss Of Oocyte Qualitymentioning

confidence: 99%

What can we learn from gene expression profiling of mouse oocytes?

Hamatani¹,

Yamada²,

Akutsu³

et al. 2008

Reproduction

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Mammalian ooplasm supports the preimplantation development and reprograms the introduced nucleus transferred from a somatic cell to confer pluripotency in a cloning experiment. However, the underlying molecular mechanisms of oocyte competence remain unknown. Recent advances in microarray technologies have allowed gene expression profiling of such tiny specimens as oocytes and preimplantation embryos, generating a flood of information about gene expressions. So, what can we learn from it? Here, we review the initiative global gene expression studies of mouse and/or human oocytes, focusing on the lists of maternal transcripts and their expression patterns during oogenesis and preimplantation development. Especially, the genes expressed exclusively in oocytes should contribute to the uniqueness of oocyte competence, driving mammalian development systems of oocytes and preimplantation embryos. Furthermore, we discuss future directions for oocyte gene expression profiling, including discovering biomarkers of oocyte quality and exploiting the microarray data for 'making oocytes'.

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Oocyte quality and treatment outcome in intracytoplasmic sperm injection cycles of polycystic ovarian syndrome patients

Cited by 131 publications

References 22 publications

Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study

What can we learn from gene expression profiling of mouse oocytes?

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