Oocyte donation in patients with Turner’s syndrome: a successful technique but with an accompanying high risk of hypertensive disorders during pregnancy

Bodri, Daniel; Vernaeve, V.; Figueras, F.; Vidal, R.; Guillén, Juan José; Coll, O.

doi:10.1093/humrep/dei396

Cited by 107 publications

(104 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…With the limited data available on births in TS persons and the well-known hypogonadal problems (21), the finding of 77 (46.1%) mothers in the 45,X/46,XX subgroup is striking but is backed up by recent Swedish data (21). We have no data to determine whether the Danish TS persons were the biological mothers, but many may have conceived after egg donation, which is becoming increasingly common among TS (22,23). Generally, the different outcomes in the three subgroups, with the mosaic subgroup being least affected, is important to note.…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic parameters and mortality in Turner syndrome

Stochholm

Hjerrild

Mortensen

et al. 2012

European Journal of Endocrinology

View full text Add to dashboard Cite

Background: Turner syndrome (TS) is characterized by hypogonadism, short adult height, increased morbidity and mortality, contrasted by self-reported normal quality of life and perception of health. Small studies have indicated a similar level of education compared with the background population. Aim: To study the socioeconomic profile in TS and the impact of these factors on mortality. Materials and methods: Register study using Danish nationwide registries. Nine hundred and seventynine TS females and 94 850 controls were included. Information concerning cohabitation, motherhoods, level of education (bachelor degree), income, retirement, and death were obtained. One hundred and three TS and 5989 controls died during the study period. For the socioeconomic parameters, median age at first relevant episode was calculated. Income was analyzed using conditional logistic regression and the other parameters using Cox regression. Results: In comparison with controls, TS had significantly fewer partnerships (hazard ratio (HR): 0.45), fewer motherhoods (HR: 0.18), and retired earlier (HR: 1.8). After the diagnosis of TS, the risk of retiring was increased. Educational attainment (HR: 1.0) as well as risk of unemployment was similar. Before the age of 30, low income was significantly more frequent; hereafter, it was similar to controls. Mortality was significantly increased (HR: 2.9) and slightly lower after adjustment for cohabitation and education (HR: 2.7). Conclusions: A divergent socioeconomic profile is apparent, with a reduced proportion of TS persons finding a partner and becoming mothers. The educational level was similar to controls. The increased mortality in TS was not materially affected after adjustment for cohabitation and education.

show abstract

Section: Discussionmentioning

confidence: 99%

Socioeconomic parameters and mortality in Turner syndrome

Stochholm

Hjerrild

Mortensen

et al. 2012

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…TS patients achieved acceptable pregnancy rates after oocyte donation. A high rate of pregnancy-associated hypertensive disorders was observed which have led to a high rate of prematurity and intrauterine growth restriction (77).…”

Section: Puberty Induction Hrt and Fertility Prospectsmentioning

confidence: 99%

TRANSITION IN ENDOCRINOLOGY: Treatment of Turner's syndrome during transition

Gawlik

Małecka-Tendera

2014

European Journal of Endocrinology

View full text Add to dashboard Cite

Transition in health care for young patients with Turner's syndrome (TS) should be perceived as a staged but uninterrupted process starting in adolescence and moving into adulthood. As a condition associated with high risk of short stature, cardiovascular diseases, ovarian failure, hearing loss and hypothyroidism, TS requires the attention of a multidisciplinary team. In this review paper, we systematically searched the relevant literature from the last decade to discuss the array of problems faced by TS patients and to outline their optimal management during the time of transfer to adult service. The literature search identified 233 potentially relevant articles of which 114 were analysed. The analysis confirmed that all medical problems present during childhood should also be followed in adult life. Additionally, screening for hypertension, diabetes mellitus, dyslipidaemia, and osteoporosis is needed. After discharge from the paediatric clinic, there is still a long way to go.

show abstract

“…Studies on obstetric outcome in TS oocyte donation pregnancies are sparse, but higher risks of complications, especially hypertensive disorders and preeclampsia, preterm birth, and intrauterine growth restriction have been reported (14,18,19). Concerns have also been raised regarding serious maternal risks and even death due to cardiovascular complications during these pregnancies (20 -24).…”

mentioning

confidence: 99%