Oocyte donation and gamete intrafallopian transfer in premature ovarian failure

Asch, Ricardo H.; Balmaceda, José P.; Ord, Teri; Borrero, Claudia; Cefalù, E; Gastaldi, Cristina; Rojas, Francisco J.

doi:10.1016/0020-7292(88)90136-1

Cited by 22 publications

(15 citation statements)

References 16 publications

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“…Subsequent reports have proven the technique to be both reproducible and highly successful (2)(3)(4). Women with ovarian failure who receive donated embryos serve as a unique model for elucidating the complex interrelations of the ovary, endometrium, and embryo.…”

mentioning

confidence: 97%

An Insight into Early Reproductive Processes through thein VivoModel of Ovum Donation

Navot

Bergh

Williams

et al. 1991

The Journal of Clinical Endocrinology & Metabolism

194

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To gain insight into early reproductive processes we have prospectively designed ovum donation protocols to elucidate several phenomena relating to embryo implantation and pregnancy sustenance. Artificial endometrial cycles with variable follicular phases were induced in 60 recipients by sequential estrogen and progesterone. A total of 964 oocytes were retrieved throughout 43 ovum donation attempts, for an average of 22.4 (range, 16-41) eggs/retrieval. The overall delivery rate per egg retrieval (donors and recipients combined) was 72.1% (31 of 43). The shortest estrogen stimulation (short follicular phase) resulting in ongoing pregnancies was 5 days in duration, while the longest (long follicular phase) was 35 days in duration before progesterone initiation. Utilization of variable length follicular phases, artificially extended the stage of endometrial receptivity to over 4 weeks. To assess the window of implantation, same age embryos were transferred onto endometrium of different maturational stages. Pregnancies were documented with embryo transfers between luteal day 1 (day 15) to luteal day 6 (day 20), extending the window of implantation in the human to at least 6 consecutive days. To evaluate the relative contribution of oocyte quality and endometrial receptivity to pregnancy outcome, common source ova were transferred onto endometrium with variable hormonal exposure. Despite the drastically different follicular phase estradiol levels and periods of exposure, similar delivery rates were attained in donor cycles (29.4%) and recipient cycles during short follicular phases (29.6%). Slightly higher delivery rates (39.4%) were observed with long follicular phases. The comparable pregnancy rates in donors and recipients are attributed to the common source oocytes regardless of endometrial stimulation.

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mentioning

confidence: 97%

An Insight into Early Reproductive Processes through thein VivoModel of Ovum Donation

Navot

Bergh

Williams

et al. 1991

The Journal of Clinical Endocrinology & Metabolism

194

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“…Although the lavage pro cedure efficiently retrieves ova, complications include retained pregnancies and endometritis in the donor (3%). Furthermore, in vivo blastocyst production and ovum yield among fertile donors is highly variable, mak ing the likelihood of retrieving a transferable fertilized ovum at best approximately 33% [5], Reports of pregnancies in agonadal women following ovarian hyperstimulation of oocyte donors implies an enhanced pregnancy rate (20-75%) over that obtained using spontaneously ovulating donors [2,6], With the advent of transvaginal aspiration techniques, a nonsurgi cal approach to in vitro fertilization is now possible, making it a reasonable option for donors willing to undergo ovarian hyperstimulation. Furthermore, the probability of obtaining ova from a single aspiration is high, limiting donor involvement as well as reducing risks from repetitive procedures.…”

Section: Discussionmentioning

confidence: 99%

“…Although preliminary, methods permitting ovarian hyperstimulation of donors may increase the probability of conception in the female recipient [2], since the likelihood of transferring a fertil ized ovum is enhanced [4], Herein we report the establishment of pregnancy in a castrate patient despite prior failed attempts at donor ovum transfer via uterine lavage. Oocytes were obtained by transvaginal ultrasound-directed aspiration of a selfselected donor.…”

Section: Introductionmentioning

confidence: 99%

“…Successful impregnations of functionally agonadal women have been reported using donated ova obtained through in vitro fertilization, gamete intrafallopian transfer, and uterine lavage [1][2][3]. Although preliminary, methods permitting ovarian hyperstimulation of donors may increase the probability of conception in the female recipient [2], since the likelihood of transferring a fertil ized ovum is enhanced [4], Herein we report the establishment of pregnancy in a castrate patient despite prior failed attempts at donor ovum transfer via uterine lavage.…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy following Oocyte Donation and in vitro Fertilization after Failed Attempts at Donor Uterine Lavage

Sauer¹,

Paulson²

1989

Gynecol Obstet Invest

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“…In 1984, Lutjen et al showed that hormone replacement therapy could 'recreate' the endometrium in these women sufficiently to support nidation of a fertilized donor embryo to produce a healthy child. Since then, other successful replacement regimes have resulted in live births (Navot et al, 1986;Dehou et al, 1987;Rosenwaks, 1987;Van Steirteghem etai, 1987;Asch et al, 1988;Devroey et al, 1989). Past investigations have not attempted to compare quantitatively the endometrial structure produced by various replacement therapy regimes to that of normal fertile women.…”

Section: Introductionmentioning

confidence: 96%

A morphometric study of the uterine glandular epithelium in women with premature ovarian failure undergoing hormone replacement therapy

Dockery

Tidey

et al. 1991

Human Reproduction

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In this study we examined the fine structure of the human glandular epithelium in women with idiopathic ovarian failure in artificial cycles produced by two different types of hormone replacement therapy (oestradiol valerate orally and either intramuscular injection of progesterone or progesterone via vaginal pessary), both of which had been claimed to be capable of supporting successful implantation. Biopsies were performed on day 19 of the artificial cycle. A variety of sterological probes were used to quantify the structural characteristics of these cells and the results obtained were compared with those from normal fertile subjects biopsied on days 2 and 5 after the luteinizing hormone (LH) surge. The glandular epithelial cells from the vaginal group had a less elaborate secretory apparatus when compared with the intramuscular group or with LH + 5 controls. Many of the features of the vaginal group suggested a continued oestrogenic influence, while the intramuscular group seemed to be more advanced than LH + 5.

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Oocyte donation and gamete intrafallopian transfer in premature ovarian failure

Cited by 22 publications

References 16 publications

An Insight into Early Reproductive Processes through thein VivoModel of Ovum Donation

An Insight into Early Reproductive Processes through thein VivoModel of Ovum Donation

Pregnancy following Oocyte Donation and in vitro Fertilization after Failed Attempts at Donor Uterine Lavage

A morphometric study of the uterine glandular epithelium in women with premature ovarian failure undergoing hormone replacement therapy

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