Oocyte Donation and Gamete Intrafallopian Transfer as Treatment for Premature Ovarian Failure

Asch, Ricardo H.; Balmaceda, José P.; Ord, Teri; Borrero, Claudia; Cefalù, E; Gastaldi, Cristina; Rojas, Francisco J.

doi:10.1016/s0140-6736(87)90450-8

Cited by 30 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unlike many IVF centres which have produced few successful pregnancies (Blakeslee 1987, Pierce 1988, Seibel 1988, this centre enjoys a highly successful reputation; it reported a pregnancy rate of 75 per cent (six out of eight cases) among the first clinical cohort of women who received donated eggs in a first attempt at pregnancy (Asch et al 1988). In the treatment protocol, the donor receives fertility drugs for one month's cycle in order to produce more than the normal one egg per month (a treatment known as controlled ovarian hyperstimulation).…”

Section: Clinical Settii^ and Medical Proceduresmentioning

confidence: 96%

All in the family: social processes in ovarian egg donation between sisters

Lessor¹

1993

Sociology Health & Illness

View full text Add to dashboard Cite

Interviews and participant observation were conducted at a US infertility clinic with women who were attempting to become pregnant with eggs donated by their biological sisters. Sisters who donated eggs were also followed and interviewed regarding their experiences, as were a number of husbands of recipients. Five significant social processes characterising the sisters' passage through egg donation are discussed: (1) negotiating dissimilar treatment experiences, (2) communicating cautiously, (3) interacting in a triad, (4) disclosing to others, and (5) 'giftgiving'. Although participants are generally satisfied with their decision to do sister-to-sister egg donation, the unprecedented procedure presents a number of difficulties. If sister-to-sister egg donation as a means to biological motherhood continues in the future, these sociological findings suggest areas in which medical personnel may need to provide social and emotional support.

show abstract

Section: Clinical Settii^ and Medical Proceduresmentioning

confidence: 96%

All in the family: social processes in ovarian egg donation between sisters

Lessor¹

1993

Sociology Health & Illness

View full text Add to dashboard Cite

show abstract

“…Assisted conception with donated oocytes has been used to achieve pregnancy in women with POF since 1987 (Asch et al, 1987;Oskarsson et al, 1990;Rotsztejn et al, 1990). Presently it remains the only means for fertility treatment in POF that carries high success rate (Anonymous, Society for Assisted Reproductive Technology and the American Society for Reproductive Medicine.…”

Section: Infertilitymentioning

confidence: 99%

Premature ovarian failure

Goswami

Conway

2005

Human Reproduction Update

549

347

View full text Add to dashboard Cite

Premature ovarian failure (POF) causing hypergonadotrophic hypogonadism occurs in 1% of women. In majority of cases the underlying cause is not identified. The known causes include: (a) Genetic aberrations, which could involve the X chromosome or autosomes. A large number of genes have been screened as candidates for causing POF; however, few clear causal mutations have been identified. (b) Autoimmune ovarian damage, as suggested by the observed association of POF with other autoimmune disorders. Anti-ovarian antibodies are reported in POF by several studies, but their specificity and pathogenic role are questionable. (c) Iatrogenic following surgical, radiotherapeutic or chemotherapeutic interventions as in malignancies. (d) Environmental factors like viral infections and toxins for whom no clear mechanism is known. The diagnosis is based on finding of amenorrhoea before age 40 associated with FSH levels in the menopausal range. Screening for associated autoimmune disorders and karyotyping, particularly in early onset disease, constitute part of the diagnostic work-up. There is no role of ovarian biopsy or ultrasound in making the diagnosis. Management essentially involves hormone replacement and infertility treatment, the only proven means for the latter being assisted conception with donated oocytes. Embryo cryopreservation, ovarian tissue cryopreservation and oocyte cryopreservation hold promise in cases where ovarian failure is foreseeable as in women undergoing cancer treatments.

show abstract

“…Various POI manifestations like infertility and vasomotor symptoms impair the quality of life and psychological well-being [45]. Oocyte donation is a reasonable option to achieve pregnancy in patients with POI, and several welltolerated medications are available to manage the side effects of hormone deprivation [46][47][48]. Established immunosuppressants, such as glucocorticoids and the calcineurin inhibitors cyclosporine and tacrolimus as well as the antiproliferative agents azathioprine and mycophenolate mofetil, are associated with serious side effects like nephrotoxicity, hypertension, diabetes, malignancies, and infections [6].…”

Section: Discussionmentioning

confidence: 99%