Oocyte Donation and Endometriosis: What Are the Lessons?

Hauzman, Erik; Garcia-Velasco, Juan A.; Pellicer, António

doi:10.1055/s-0032-1333483

Cited by 38 publications

(35 citation statements)

References 42 publications

(45 reference statements)

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“…Consequently, we chose to use a 10 % dilution of PF for this study. We observed a significant decrease in blastocyst development from 63.6 to 38.9 % with the addition of 10 % PF-E, confirming the embryotoxic impact of endometriotic peritoneal fluid [27]. The addition of 10 % PF-NL to the embryo culture media did not result in a significant decrease in the BDR.…”

Section: Discussionsupporting

confidence: 60%

Dexamethasone attenuates the embryotoxic effect of endometriotic peritoneal fluid in a murine model

Heitmann

Tobler

Gillette

et al. 2015

J Assist Reprod Genet

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Section: Discussionsupporting

confidence: 60%

Dexamethasone attenuates the embryotoxic effect of endometriotic peritoneal fluid in a murine model

Heitmann

Tobler

Gillette

et al. 2015

J Assist Reprod Genet

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“…Any problem in these systems, such as endometriosis-induced inflammation, impairs reproductive function [18]. Endometriosis characteristically causes chronic intraperitoneal inflammation and may cause infertility by several pathways, including disturbed folliculogenesis, reduced oocyte quality, impaired embryo development, and reduced endometrial receptivity [19, 20]. Inflammatory factors, such as TNF-α, are higher in the peritoneal and follicular fluid of infertile women with endometriosis compared with normal women [21].…”

Section: Discussionmentioning

confidence: 99%

“…Oocyte donation studies might be able to determine whether oocyte quality or endometrial receptivity is more important for endometriosis-induced infertility. Reviews on oocyte donation have shown a higher rate of implantation problems and a lower pregnancy rate in patients receiving oocytes from donors with endometriosis, while outcomes are not affected by the status of the recipient [20]. These data suggest that infertility in women with endometriosis may be the result of poor oocyte quality due to an increase in inflammatory factors rather than endometrial issues [20].…”

Section: Discussionmentioning

confidence: 99%

“…Reviews on oocyte donation have shown a higher rate of implantation problems and a lower pregnancy rate in patients receiving oocytes from donors with endometriosis, while outcomes are not affected by the status of the recipient [20]. These data suggest that infertility in women with endometriosis may be the result of poor oocyte quality due to an increase in inflammatory factors rather than endometrial issues [20]. There are 3 important factors for embryo implantation, including embryo (oocyte quality) quality, endometrial receptivity, and synchronization between the embryo and endometrium.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Etanercept on the Success of Assisted Reproductive Technology in Patients with Endometrioma

Önalan

Tohma

Zeyneloğlu³

2017

Gynecol Obstet Invest

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Aims: To determine the effects of a tumor necrosis factor inhibitor (etanercept) on pregnancy outcomes in patients with endometrioma who were treated with assisted reproductive technology. Methods: Sixty-eight infertile patients who had endometrioma were included in our retrospective case-control study. We administered etanercept (Enbrel, 50 mg in 1 mL intramuscularly) to 19 patients on the second day of their previous menstrual cycle. All patients were treated with assisted reproductive technology. Pregnancy and live birth rates (LBR) were documented. Results: When all other parameters (age, body mass index, infertility) are supposed to be constant, the clinical pregnancy rate was significantly higher in patients who used etanercept in an antagonist protocol than in patients who did not use etanercept (χ² = 5.547; p = 0.019) but LBR did not reach a statistical significance (χ² = 3.179; p = 0.075). The use of etanercept had an OR of 4.17 (95% CI 1.23–14.14) compared with not using etanercept for clinical pregnancy rate. The use of etanercept increased the rate of pregnancy (χ² = 6.55; p = 0.01). The pregnancy rate with the use of etanercept had an OR of 4.23 (95% CI 1.35–13.25) compared with patients who did not use etanercept. In the same way, the use of etanercept increased LBR twofold, but it is not significant in the border line (χ² = 3.771; p = 0.052). Conclusions: Etanercept may be a new non-hormonal therapy that may be an adjunct to treatment of infertile women with endometrioma. However, the safety of etanercept on embryos and fetuses has not been fully clarified.

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“…This suggestion is in line with studies from oocyte donation programmes. Implantation rates were reduced with oocytes from women with endometriosis transferred to women without endometriosis, whereas embryos from healthy donors, transferred to women with endometriosis, did not affect implantation rates [12].…”

Section: Introductionmentioning

confidence: 87%

Intrafollicular inflammatory cytokines but not steroid hormone concentrations are increased in naturally matured follicles of women with proven endometriosis

Bersinger²,

Mueller³

et al. 2017

J Assist Reprod Genet

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Purpose The aim of this study was to assess whether the intrafollicular cytokine profile in naturally developed follicles is different in women with endometriosis, possibly explaining the lower reproductive outcome in endometriosis patients. Methods A matched case-control study was conducted at a university-based infertility and endometriosis centre. The study population included 17 patients with laparoscopically and histologically confirmed endometriosis (rAFS stages II-IV), each undergoing one natural cycle IVF (NC-IVF) treatment cycle between 2013 and 2015, and 17 age-matched NC-IVF women without diagnosed endometriosis (control group). Follicular fluid and serum was collected at the time of follicle aspiration. The concentrations of inflammatory cytokines (IL-1β, IL-6, IL-8, IL-15, IL-18, TNF-α) and hormones (testosterone, estradiol, AMH) were determined in follicular fluid and serum by single or multiplexed immunoassay and compared between both groups. Results In the follicular fluid, IL-1β and IL-6 showed significantly (P < 0.001 and 0.01, respectively) higher median concentrations in the endometriosis group than in the control group and a tendency towards endometriosis severity (rAFS stage) dependence. The levels of the interleukins detectable in follicular fluid were significantly higher than those in the serum (P < 0.01). Follicular estradiol concentration was lower in severe endometriosis patients than in the control group (P = 0.036). Follicular fluid IL-1β and IL-6 levels were not correlated with estradiol in the same compartment in neither patient group. Conclusions In women with moderate and severe endometrioses, some intrafollicular inflammatory cytokines are upregulated and not correlated with intrafollicular hormone concentrations. This might be due to the inflammatory microenvironment in endometriosis women, affecting follicular function and thereby possibly contributing to the reproductive dysfunction in endometriosis.

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Oocyte Donation and Endometriosis: What Are the Lessons?

Cited by 38 publications

References 42 publications

Dexamethasone attenuates the embryotoxic effect of endometriotic peritoneal fluid in a murine model

Dexamethasone attenuates the embryotoxic effect of endometriotic peritoneal fluid in a murine model

Effect of Etanercept on the Success of Assisted Reproductive Technology in Patients with Endometrioma

Intrafollicular inflammatory cytokines but not steroid hormone concentrations are increased in naturally matured follicles of women with proven endometriosis

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