Oocyte cryopreservation in oncological patients

Porcu, Eleonora; Fabbri, Raffaella; Damiano, Giuseppe; Fratto, R.; Giunchi, S.; Venturoli, Stefano

doi:10.1016/j.ejogrb.2003.11.004

Cited by 54 publications

(32 citation statements)

References 17 publications

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“…The technical experience with oocyte freezing in Italy is one of the widest in the world (20)(21)(22)(23)(24) and oocyte freezing is frequently offered to oncological patients. We observed that the number of mature and oocytes, was significantly (about 40%) lower when Letrozole was used (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Is Letrozole needed for controlled ovarian stimulation in patients with estrogen receptor-positive breast cancer?

Revelli

Porcu

Levi-Setti

et al. 2013

Gynecological Endocrinology

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SummaryObjective: To assess the advantages and disadvantages of using Letrozole for controlled ovarian stimulation (COH) in young patients with estrogen receptorpositive (ER+) breast cancer, wishing to cryopreserve oocytes. Design: Retrospective cohort analysis.Setting: Sixteen Italian Units for Reproductive Medicine and In Vitro Fertilization.Methods: Data of 50 ER+ breast cancer patients undergoing COH to cryopreserve oocytes before gonadotoxic chemotherapy with a Letrozole plus gonadotropins (Le+Gn) protocol were compared with those of 25 young women with ER-breast cancer, submitted to COH using a protocol with gonadotropins alone (Gn-only). Results:The Le+Gn protocol implied a significantly lower total Gn consumption and allowed to maintain significantly lower circulating E2 levels at all checkpoints throughout stimulation (peak E2 value 446 ± 357 vs.1553 ± 908 pg/ml, respectively; p=0.001). On the other side, the Le+Gn protocol allowed a significantly lower yield of oocytes available for cryostorage (6.6 ± 3.5 vs. 8 ± 5, respectively; p=0.038).. Conclusions:In breast cancer patients, the association of Letrozole to Gn significantly reduces the number of oocytes available for cryostorage in comparison with the use of Gn alone. On the other side, it is associated with significantly lower E2 levels during the whole stimulation cycle, a safety issue that has been traditionally considered advantageous in case of ER+ cancers.

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Section: Discussionmentioning

confidence: 99%

Is Letrozole needed for controlled ovarian stimulation in patients with estrogen receptor-positive breast cancer?

Revelli

Porcu

Levi-Setti

et al. 2013

Gynecological Endocrinology

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“…Damage of the mitotic spindle results in a more frequent occurrence of aneuploidy. As a consequence of the above-mentioned processes a hardening of zona pellucida may occur, although this problem can be solved by using intracytoplasmatic sperm injection (ICSI) [20][21][22][23]. There is a significant difference between the sensitivity of mature and premature oocytes to freezing process.…”

Section: Oocyte Cryopreservationmentioning

confidence: 99%

“…The first child from a cryopreserved oocyte was born in 1986. There are 200-250 such pregnancies or births worldwide [20][21][22]. There are many technical problems to face when using this method.…”

Section: Oocyte Cryopreservationmentioning

confidence: 99%

“…Premature oocytes are CEMED n 21 n smaller, characterized by a lower metabolic ratio. Due to lack of some anatomical structures they are significantly more resistant to freezing than mature oocytes [22,27]. Deep freezed tissues can be autotransplanted after thawing or "cultured" aiming maturation of primordial follicles and premature oocytes.…”

Section: Cryopreservation Of Ovarian Tissuementioning

confidence: 99%

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Procedures for fertility preservation in female cancer patients

Langmár¹,

Iványi²,

Bánhidy³

et al. 2009

Clinical and Experimental Medical Journal

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n REVIEWS n Modern anticancer drugs and novel oncotherapeutic methods have resulted in increasingly better survival rates and quality of life. However, this therapeutic success has been accompanied by the loss of fertility and premature menopause in many women cured of their disease. Consequently, efforts to preserve reproductive functions are of increasing importance [1][2][3][4][5][6]. The significance of such research is further emphasized by current statistical data showing that approximately one in 700 adults is a survivor of a certain childhood malignant disease. It is estimated that by the year 2010 this proportion will significantly increase and almost one in 250 adults will suffer from the late negative consequences of treatments of childhood cancer, includ-

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“…A serious problem with premature oocytes is that after thawing only a few oocytes can be made eligible for fertilization. Mature (metaphase stage II) oocytes are especially sensitive to low temperatures [20,[22][23]. Special preservative solution and freezing procedures have been developed to improve the results.…”

Section: Oocyte Cryopreservationmentioning

confidence: 99%