Oocyte competency is the key to embryo potential

Keefe, David L.; Kumar, Mithilesh; Kalmbach, Keri

doi:10.1016/j.fertnstert.2014.12.115

Cited by 164 publications

(131 citation statements)

References 75 publications

(118 reference statements)

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“…The results of this study are not sufficient to confirm a causal relationship between the rate of embryo development and aneuploidy in ageing patients. It is, however, known that oocytes of older patients exhibit an impaired development potential, which may be associated with both aneuploidy and slower development (Keefe et al, 2015).…”

Section: Article In Pressmentioning

confidence: 99%

Does slow embryo development predict a high aneuploidy rate on trophectoderm biopsy?

Piccolomini

Nicolielo

Bonetti

et al. 2016

Reproductive BioMedicine Online

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Section: Article In Pressmentioning

confidence: 99%

Does slow embryo development predict a high aneuploidy rate on trophectoderm biopsy?

Piccolomini

Nicolielo

Bonetti

et al. 2016

Reproductive BioMedicine Online

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“…A number of studies have reported a heritable component to telomere length (Bouwhuis, Verhulst, Bauch, & Vedder, 2018;Dugdale & Richardson, 2018). Moreover, offspring telomere length could also be subjected to maternal effects, for example via differences in embryonic provisioning and/ or embryonic environment (McLennan et al, 2018a;Noguera, Metcalfe, Reichert, & Monaghan, 2016), as well as potential maternal effects on oocyte telomere length (Keefe, Kumar, & Kalmbach, 2015). Further, since oviparous offspring interact with the environment at an earlier life stage, it is possible that the telomeres of these offspring could then be differentially affected by environmental factors, for example via temperature and growth effects on early life development (McLennan et al, 2018b;Monaghan & Ozanne, 2018;Vedder, Verhulst, Zuidersma, & Bouwhuis, 2018).…”

Section: Introductionmentioning

confidence: 99%

Distinct telomere differences within a reproductively bimodal common lizard population

2019

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Different strategies of reproductive mode, either oviparity (egg‐laying) or viviparity (live‐bearing), will be associated with a range of other life‐history differences that are expected to affect patterns of ageing and longevity. It is usually difficult to compare the effects of alternative reproductive modes because of evolutionary and ecological divergence. However, the very rare exemplars of reproductive bimodality, in which different modes exist within a single species, offer an opportunity for robust and controlled comparisons.One trait of interest that could be associated with life history, ageing and longevity is the length of the telomeres, which form protective caps at the chromosome ends and are generally considered a good indicator of cellular health. The shortening of these telomeres has been linked to stressful conditions; therefore, it is possible that differing reproductive costs will influence patterns of telomere loss. This is important because a number of studies have linked a shorter telomere length to reduced survival.Here, we have studied maternal and offspring telomere dynamics in the common lizard (Zootoca vivipara). Our study has focused on a population where oviparous and viviparous individuals co‐occur in the same habitat and occasionally interbreed to form admixed individuals.While viviparity confers many advantages for offspring, it might also incur substantial costs for the mother, for example require more energy. Therefore, we predicted that viviparous mothers would have relatively shorter telomeres than oviparous mothers, with admixed mothers having intermediate telomere lengths. There is thought to be a heritable component to telomere length; therefore, we also hypothesized that offspring would follow the same pattern as the mothers.Contrary to our predictions, the viviparous mothers and offspring had the longest telomeres, and the oviparous mothers and offspring had the shortest telomeres. The differing telomere lengths may have evolved as an effect of the life‐history divergence between the reproductive modes, for example due to the increased growth rate that viviparous individuals may undergo to reach a similar size at reproduction. A free http://onlinelibrary.wiley.com/doi/10.1111/1365-2435.13408/suppinfo can be found within the Supporting Information of this article.

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“…Oocyte competence refers to the capacity to complete meiotic maturation and to support embryo development. Features associated with oocyte quality and competence include follicular size, follicular microenvironment, oocyte aging, oocyte‐cumulus cells communication, oxidative stress, metabolism, growth factors, and oocyte transcriptional activity (Algriany et al, ; Bagg et al, ; Fair, ; Dumesic et al, ; Keefe et al, ; Moussa et al, ). Studies in mice, pigs, cattle, and humans revealed that the capacity of oocytes to support embryo development in vitro is negatively correlated with the length of the first cell cycle and is affected by the cell cleavage kinetics of early developing embryos (Bos‐Mikich et al, ; Kobayashi et al, ; Henrique Barreta et al, ; Isom et al, ; Bohrer et al, ).…”

Section: Introductionmentioning

confidence: 99%

Altered expression of BRG1 and histone demethylases, and aberrant H3K4 methylation in less developmentally competent embryos at the time of embryonic genome activation

Glanzner

Wachter

Coutinho

et al. 2016

Molecular Reproduction Devel

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Epigenetics is a fundamental regulator underlying many biological functions, such as development and cell differentiation. Epigenetic modifications affect key chromatin regulation, including transcription and DNA repair, which are critical for normal embryo development. In this study, we profiled the expression of epigenetic modifiers and patterns of epigenetic changes in porcine embryos around the period of embryonic genome activation (EGA). We observed that Brahma-related gene 1 (BRG1) and Lysine demethylase 1A (KDM1A), which can alter the methylation status of lysine 4 in histone 3 (H3K4), localize to the nucleus at Day 3-4 of development. We then compared the abundance of epigenetic modifiers between early- and late-cleaving embryos, which were classified based on the time to the first cell cleavage, to investigate if their nuclear localization contributes to developmental competence. The mRNA abundance of BRG1, KDM1A, as well as other lysine demethylases (KDM1B, KDM5A, KDM5B, and KDM5C), were significantly higher in late- compared to early-cleaving embryos near the EGA period, although these difference disappeared at the blastocyst stage. The abundance of H3K4 mono- (H3K4me) and di-methylation (H3K4me2) during the EGA period was reduced in late-cleaving and less developmentally competent embryos. By contrast, BRG1, KDM1A, and H3K4me2 abundance was greater in embryos with more than eight cells at Day 3-4 of development compared to those with fewer than four cells. These findings suggest that altered epigenetic modifications of H3K4 around the EGA period may affect the developmental capacity of porcine embryos to reach the blastocyst stage. Mol. Reprod. Dev. 84: 19-29, 2017. © 2016 Wiley Periodicals, Inc.

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Oocyte competency is the key to embryo potential

Cited by 164 publications

References 75 publications

Does slow embryo development predict a high aneuploidy rate on trophectoderm biopsy?

Does slow embryo development predict a high aneuploidy rate on trophectoderm biopsy?

Distinct telomere differences within a reproductively bimodal common lizard population

Altered expression of BRG1 and histone demethylases, and aberrant H3K4 methylation in less developmentally competent embryos at the time of embryonic genome activation

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