Oocyte competence is maintained by m6A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development

Hu, Yue; Ouyang, Zhangyi; Sui, Xuesong; Qi, Meijie; Li, Mingrui; He, Yuanlin; Cao, Yumeng; Cao, Qiqi; Lu, Qiao; Zhou, Shuai; Liu, Lu; Liu, Li; Shen, Bin; Shu, Wenjie; Huo, Ran

doi:10.1038/s41418-020-0516-1

Cited by 75 publications

(63 citation statements)

References 56 publications

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“…Based on the different functions of m 6 A RNA methylation modulators, they are usually classified into “writers”, “erasers”, and “readers” ( 4 ). The “writers” catalyze the formation of m 6 A, including Methyltransferase-like 3 (METTL3) ( 5 ), METTL14 ( 6 ), Wilms tumor 1-associated protein (WTAP) ( 7 ), RNA Binding Motif Protein 15 (RBM15) ( 8 ) and KIAA1429 ( 9 ). The “erasers”, removing m 6 A modification from RNA, compose of fat mass and obesity-associated protein (FTO) ( 10 ) and alkB homologue 5 (ALKBH5) ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Analysis and Validation of circRNA-miRNA Network in Regulating m6A RNA Methylation Modulators Reveals CircMAP2K4/miR-139-5p/YTHDF1 Axis Involving the Proliferation of Hepatocellular Carcinoma

2021

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The m6A RNA methylation modulators play a crucial role in regulating hepatocellular carcinoma (HCC) progression. The circular RNA (circRNA) regulatory network in regulating m6A RNA methylation modulators in HCC remains largely unknown. In this study, 5 prognostic m6A RNA methylation modulators in HCC were identified from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) projects. The differentially expressed microRNAs (DEmiRNAs) and circRNAs (DEcircRNAs) between paired tumor and normal tissues were screened out from TCGA and or Gene Expression Omnibus (GEO) database to construct the circRNA-miRNA- m6A RNA methylation modulator regulatory network, which included three m6A RNA methylation modulators (HNRNPC, YTHDF1, and YTHDF2), 11 DEmiRNAs, and eight DEcircRNAs. Among the network, hsa-miR-139-5p expression was negatively correlated with YTHDF1. Hsa-miR-139-5p low or YTHDF1 high expression was correlated with high pathological grade, advanced stage and poor survival of HCC. Additionally, cell cycle, base excision repair, and homologous recombination were enriched in YTHDF1 high expression group by GSEA. A hub circRNA regulatory network was constructed based on hsa-miR-139-5p/YTHDF1 axis. Furthermore, hsa_circ_0007456(circMAP2K4) was validated to promote HCC cell proliferation by binding with hsa-miR-139-5p to promote YTHDF1 expression. Taken together, we identified certain circRNA regulatory network related to m6A RNA methylation modulators and provided clues for mechanism study and therapeutic targets for HCC.

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Section: Introductionmentioning

confidence: 99%

Analysis and Validation of circRNA-miRNA Network in Regulating m6A RNA Methylation Modulators Reveals CircMAP2K4/miR-139-5p/YTHDF1 Axis Involving the Proliferation of Hepatocellular Carcinoma

2021

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“…In oocyte, its growth is accompanied by the accumulation of post-transcriptional regulation and abundant RNAs’ modification. Loss of KIAA1429 leads to abnormal RNA metabolism in oocytes and modulates follicular development 24 . In gastric cancer, KIAA1429 is upregulated in tissue and cells, and the upregulated KIAA1429 promotes the proliferation by stabilizing c-Jun mRNA via m 6 A-independent manner 25 .…”

Section: Discussionmentioning

confidence: 99%

N6-methyladenosine (m6A) methyltransferase KIAA1429 accelerates the gefitinib resistance of non-small-cell lung cancer

Tang¹,

Han

Tong

et al. 2021

Cell Death Discov.

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N6-methyladenosine (m6A) modification has been convincingly identified to be a critical regulator in human cancer. However, the contribution of m6A to NSCLC gefitinib resistance is still largely unknown. Here, we screened and identified that m6A methyltransferase KIAA1429 was highly expressed in gefitinib-resistant NSCLC cells (PC9-GR), tissues, and closely related to unfavorable survival. Functionally, KIAA1429 accelerated the gefitinib resistance of NSCLC in vitro. Depletion of KIAA1429 repressed the tumor growth of PC9-GR cells in vivo. Mechanistically, KIAA1429 enhanced the mRNA stability of HOXA1 through targeting its 3′-untranslated regions (3′-UTR). Overall, our findings indicate that KIAA1429 plays essential oncogenic roles in NSCLC gefitinib resistance, which may provide a feasible therapeutic target for NSCLC.

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“…The writers are responsible for installing m 6 A marks to RNA, the erasers selectively remove m 6 A marks, and the readers recognize m 6 A marks specifically. m 6 A methyltransferase complex, also called "m 6 A writer, " is composed of methyltransferase-like 3 (METTL3), METTL14, WT-associated protein (WTAP), RBM15/RBM15B, KIAA1429, and ZC3H13 (Liu et al, 2014;Ping et al, 2014;Knuckles et al, 2018;Wen et al, 2018;Hu et al, 2020). m 6 A erasers, FTO and ALKBH5, are the main demethylases (Jia et al, 2011;Zheng et al, 2013).…”

Section: Regulation Of Rna M 6 a Modificationmentioning

confidence: 99%

RNA m6A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis

Wang

Feng

Han

et al. 2021

Front. Cell Dev. Biol.

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N6-methyladenosine (m6A) is a commonly modification of mammalian mRNAs and plays key roles in various cellular processes. Emerging evidence reveals the importance of RNA m6A modification in maintaining stem cell function in normal hematopoiesis and leukemogenesis. In this review, we first briefly summarize the latest advances in RNA m6A biology, and further highlight the roles of m6A writers, readers and erasers in normal hematopoiesis and acute myeloid leukemia. Moreover, we also discuss the mechanisms of these m6A modifiers in preserving the function of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs), as well as potential strategies for targeting m6A modification related pathways. Overall, we provide a comprehensive summary and our insights into the field of RNA m6A in normal hematopoiesis and leukemia pathogenesis.

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Oocyte competence is maintained by m6A methyltransferase KIAA1429-mediated RNA metabolism during mouse follicular development

Cited by 75 publications

References 56 publications

Analysis and Validation of circRNA-miRNA Network in Regulating m6A RNA Methylation Modulators Reveals CircMAP2K4/miR-139-5p/YTHDF1 Axis Involving the Proliferation of Hepatocellular Carcinoma

Analysis and Validation of circRNA-miRNA Network in Regulating m6A RNA Methylation Modulators Reveals CircMAP2K4/miR-139-5p/YTHDF1 Axis Involving the Proliferation of Hepatocellular Carcinoma

N6-methyladenosine (m6A) methyltransferase KIAA1429 accelerates the gefitinib resistance of non-small-cell lung cancer

RNA m6A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis

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