Oocyte and embryo quality as well as pregnancy rate in intracytoplasmic sperm injection are not affected by high follicular phase serum progesterone

Ubaldi, Filippo; Smitz, Johan; Wisanto, A.; Joris, Hubert; Schiettecatte, Johan; Derde, Marie-Paule; Borkham, E.; Steirteghem, A. Van; Devroey, Paul

doi:10.1093/oxfordjournals.humrep.a135864

Cited by 79 publications

(49 citation statements)

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“…In this study, we measured the incidence of premature luteinization and its possible effect on IVF outcomes in a large population of PCOS patients. The incidence of premature luteinization ranges from 2 % to 40 % in IVF general patients [4,[25][26][27]. Bosch et al reported frequent premature luteinization and diminished PR with the introduction of a GnRH antagonist to their COH protocol for IVF in patients [3].…”

Section: Discussionmentioning

confidence: 99%

Progesterone levels on the hCG day and outcomes in vitro fertilization in women with polycystic ovary syndrome

Peng

Guo

Long

et al. 2012

J Assist Reprod Genet

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Background The purpose of this study was to determine the incidence of premature luteinization in patients with polycystic ovary syndrome and compared the main determinants of success in in-vitro fertilization in PCOS patients with and without premature luteinization. Methods Retrospective analysis of 180 PCOS women of Chinese Han origin with infertility who underwent controlled ovarian hyperstimulation (COH) with an exogenous gonadotropin/GnRH antagonist protocol. Hormone levels on the hCG day and IVF outcomes were assessed. Results The incidence of premature luteinization was 23.3 %. Compared with PCOS patients without premature luteinization, PCOS patients with premature luteinization (PL) had a higher number of oocytes retrieved (18.20±6.6 vs 15.08±7.3, p00.037) and a higher fertilization rate (72.9± 1.9 vs63.1±2.3, p00.033), but clinical pregnancy rates were no statistical significance (53.3 vs 56.0, p00.836). Though the implantation rate was higher in no premature luteinization patients, but the difference was not statistically significant (37.7 vs 30.3, p00.115). Conclusion The PCOS patients with premature luteinization had a higher fertilization rate and high number of oocytes retrieved, and the similar implantation rate and clinical PRs as PCOS patients without premature luteinization.

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Section: Discussionmentioning

confidence: 99%

Progesterone levels on the hCG day and outcomes in vitro fertilization in women with polycystic ovary syndrome

Peng

Guo

Long

et al. 2012

J Assist Reprod Genet

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“…as others have found that a subtle Prog rise has no negative effect on the pregnancy outcome [8,10,17] . The results are varied and may be due to methodological issues.…”

Section: Discussionmentioning

confidence: 79%

“…A subtle rise in serum progesterone (Prog) on the day of hCG administration is common and has been reported to occur in 5-35% of IVF cycles incorporating a GnRH agonist (GnRH-a) [7][8][9][10] or 20-38.3% with a GnRH antagonist for COH [11,12] .…”

Section: Introductionmentioning

confidence: 99%

“…Several studies reported that a subtle Prog rise may negatively affect the pregnancy outcome [7,9,14] , whereas others have found that a subtle Prog rise has no negative effect on the pregnancy outcome [8,10,15] . The effect of a subtle Prog rise in implantation and pregnancy rates during GnRH antagonist IVF embryo transfer cycles is still unclear but all three related studies have shown that a subtle Prog rise may lower implantation and pregnancy rate in GnRH antagonist stimulation protocol [12,15,16] .…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of Progesterone Changes in Women with Subtle Progesterone Rise in Recombinant Follicle-Stimulating Hormone and Gonadotropin-Releasing Hormone Antagonist Cycle

Seow

Lin

Hsieh

et al. 2010

Gynecol Obstet Invest

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Background: To assess the characteristics of progesterone (Prog) changes in women with a subtle Prog rise in recombinant follicle-stimulating hormone (r-FSH) and GnRH antagonist cycles. Methods: We enrolled 233 patients undergoing controlled ovarian hyperstimulation with r-FSH and GnRH antagonist for IVF or ICSI. A subtle Prog rise 1 day before hCG administration was defined as a Prog value of ≧1.2 ng/ml. Results: 100 of 233 cycles (42.9%) showed a subtle Prog rise in this study. The mean serum Prog levels and area under curve (AUC) in the group with Prog ≧1.2 ng/ml was significantly higher than that in the Prog <1.2 ng/ml group on cycle day 8 (1.17 ± 0.4 and 0.80 ± 0.3 ng/ml, respectively, for Prog level, p = 0.003; 571 ± 123 and 763 ± 250 for AUC, p = 0.001), and remained significantly higher until the day of hCG administration. Moreover, 55% of the patients on cycle day 9, 65% on cycle day 10, 75% on cycle day 11 and 85% on cycle day 12 in the Prog ≧1.2 ng/ml group have a serum Prog level of ≧1.2 ng/ml. Conclusion: A subtle Prog rise may occur as early as cycle day 8 in r-FSH/GnRH antagonist cycles.

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“…Ovarian stimulation was done as previously described (Ubaldi et al, 1995). The combination of vaginal ultrasound results and serum oestradiol concentrations indicated that at least nine follicles were present (Vandervorst et al, 1998).…”

Section: Icsi Proceduresmentioning

confidence: 99%

Pregnancy after preimplantation genetic diagnosis for Charcot-Marie- Tooth disease type 1A

Vos

Sermon²,

Velde³

et al. 1998

Molecular Human Reproduction

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Charcot-Marie-Tooth (CMT) disease type 1A is an autosomal dominant peripheral neuropathy characterized by slow progressive distal muscle wasting and weakness, and decreased nerve conduction velocities. Most CMT1A cases (>98%) are caused by a duplication of a 1.5 Mb region on the short arm of chromosome 17 containing the PMP22 gene. A couple with a previous history of CMT followed by termination of pregnancy was referred to our centre for preimplantation genetic diagnosis (PGD). The husband carries the CMT1A duplication which can be detected by polymerase chain reaction (PCR) analysis using polymorphic (CA) n markers localized within the duplication. PCR amplification of genomic DNA of the parents-to-be with one of the two primers labelled with fluorescein, followed by automated laser fluorescence (ALF) gel electrophoresis of the amplified fragments allows the distinction between both genotypes. Embryos obtained after intracytoplasmic sperm injection (ICSI) were evaluated for the presence of the normal allele of the father. PCR with single Epstein-Barr virus-transformed lymphoblasts and blastomeres resulted in 91.4 and 93.5% amplification efficiency respectively, whereas none of the blank controls gave a positive signal. Allele drop-out (ADO) was observed in eight out of 32 lymphoblasts (25%) or in five out of 21 blastomeres (23.8%). However, within this set-up ADO will never lead to transfer of an affected embryo. A first ICSI-PGD cycle did not result in embryo transfer for the patient. A second cycle involved 10 mature oocytes of which eight were fertilized, resulting in five embryos for biopsy. Two unaffected embryos were available for transfer and resulted in a singleton pregnancy. The genotype of the fetus has been confirmed healthy by chorionic villus sampling.

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Oocyte and embryo quality as well as pregnancy rate in intracytoplasmic sperm injection are not affected by high follicular phase serum progesterone

Cited by 79 publications

References 0 publications

Progesterone levels on the hCG day and outcomes in vitro fertilization in women with polycystic ovary syndrome

Progesterone levels on the hCG day and outcomes in vitro fertilization in women with polycystic ovary syndrome

Characteristics of Progesterone Changes in Women with Subtle Progesterone Rise in Recombinant Follicle-Stimulating Hormone and Gonadotropin-Releasing Hormone Antagonist Cycle

Pregnancy after preimplantation genetic diagnosis for Charcot-Marie- Tooth disease type 1A

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