Onychomycosis: Clinico-mycologic study of 130 patients from Himachal Pradesh, India

Gupta, Mrinal; Sharma, Nand Lal; Kanga, Anil; Mahajan, Vikram K.; Tegta, Geeta Ram

doi:10.4103/0378-6323.37055

Cited by 72 publications

(30 citation statements)

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“…However, nail specimen cultures in the present study showed highly positive results for the presences of fungal organisms which are in accordance with Raghavendra et al The isolated fungal results in our study are compatible with many other studies reported that dermatophytes, mainly Trichophyton rubrum "T. rubrum", as the most common fungal organisms involved in onychomycosis followed by yeasts, mainly candida albicans ''C. albicans'', in many countries as Great Britain, Egypt and India [5,13,[20][21][22][23][24]. Biofilm has become the focus of the era and is considered to be one of the important causes of chronic recalcitrant infections globally.…”

Section: Discussionsupporting

confidence: 82%

Clinico-Mycological Study of Fungal Biofilms in Recalcitrant Onychomycosis

Mr¹,

Mh²,

Hm³

et al. 2017

Mycobact Dis

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Objective: Studying the incidence of different predisposing factors of onychomycosis and the ability of fungal isolates to form biofilms. Background:Onychomycosis chronicity is referred to difficulties in eliminating the causative pathogens. Biofilms have become focus of era and considered to be one of the globally important causes of chronic recalcitrant infections. Fungi implicated in onychomycosis have the ability to form biofilms ''surface-attached multi-cellular communities''. Biofilm associated fungi acquire higher adaptive ability to overcome stressful conditions, higher antifungal resistance and evasion of host defensive systems. Moreover, they express community-based differential genes and more virulence activities.

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Section: Discussionsupporting

confidence: 82%

Clinico-Mycological Study of Fungal Biofilms in Recalcitrant Onychomycosis

Mr¹,

Mh²,

Hm³

et al. 2017

Mycobact Dis

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“…[28] The increased prevalence of toenail infection in males could be the result of more traumas in the nails and the more common use of occlusive footwear. Finger nails were also more frequently affected than toenails in many other studies.…”

Section: Discussionmentioning

confidence: 99%

Current mycological profile of onychomycosis in Kashmir valley: A hospital-based study

Nazir

Kanth

2017

J Lab Physicians

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INTRODUCTION:Onychomycosis is a common nail ailment associated with significant physical and psychological morbidity. It is caused by dermatophytes, nondermatophytic molds, and yeasts. Increased prevalence in the recent years is attributed to enhanced longevity, comorbid conditions such as diabetes, avid sports participation, and emergence of HIV.AIMS AND OBJECTIVES:This study was undertaken to identify the mycological profile and etiological agents associated with this infection.MATERIALS AND METHODS:One hundred and twenty-nine cases of clinically suspected onychomycosis were included in this study. Clinical patterns were noted, and samples collected from most severely affected nail. They were subjected to direct microscopy and culture.RESULTS:The microscopic and/or culture examination was positive in 64.34% of cases. The most common clinical type was distal lateral subungual onychomycosis in 42 (50.60%) Candida sp. was the most common fungal agent among yeasts, followed by Trichophyton sp among dermatophytes and Aspergillus among nondermatophytic molds. Females were affected more than males and fingernails were affected more frequently than toenails.CONCLUSION:Onychomycosis is a significant and important disease which can cause many physical, physiological, and occupational problems, considerably impairing patient quality of life. Hence, fungal cultures are of paramount importance in all suspected cases of onychomycosis because the antifungal agent with an appropriate spectrum of activity can only be used if the underlying fungal pathogen is identified correctly.

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“…Chronic paronychia is an inflammatory disorder of the proximal nail fold, reactive to irritants and allergens2,3,4. When the cuticle separates from the nail plate, the region between the proximal nail fold and nail plate is vulnerable to infection by bacterial and fungal pathogens3.…”

mentioning

confidence: 99%

“…When the cuticle separates from the nail plate, the region between the proximal nail fold and nail plate is vulnerable to infection by bacterial and fungal pathogens3. Colonization with C. albicans or bacteria may occur in the lesion2,4. Paronychia is associated with 84.2% of candidal onychomycosis; the initial paronychia leads to nail discoloration, and then, dystrophy ensues4.…”

mentioning

confidence: 99%

“…Colonization with C. albicans or bacteria may occur in the lesion2,4. Paronychia is associated with 84.2% of candidal onychomycosis; the initial paronychia leads to nail discoloration, and then, dystrophy ensues4. Patients with chronic mucocutaneous candidiasis involving the nail plate and proximal nail fold can show swelling of the proximal nail fold, with considerable expansion of the terminal phalanx, and develop a pseudo-clubbing, or 'chicken drumstick' appearance1,5.…”

mentioning

confidence: 99%

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