Onychomycosis by Fusarium oxysporum probably acquired in utero

Carvalho, Vânia Oliveira; Vicente, Vânia A.; Werner, Betina; Gomes, Renata Rodrigues; Fornari, Gheniffer; Herkert, Patricia Fernanda; Rodrigues, Cristina O.; Abagge, Kerstin Taniguchi; Robl, Renata; Camiña, Ricardo Hohmann

doi:10.1016/j.mmcr.2014.09.005

Cited by 11 publications

(14 citation statements)

References 17 publications

(14 reference statements)

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“…Fusarium onychomycosis was eradicated in only 40% of adult patients in a study performed in Italy . In this aspect, toenails are most affected (61.8%) and involvement of the nail is less severe in immunocompetent hosts with long evolution without complications . Therefore, a thorough diagnostic work‐up for onychomycosis by Fusarium spp.…”

Section: Discussionmentioning

confidence: 99%

Genetic diversity and antifungal susceptibility of Fusarium isolates in onychomycosis

Rosa

Heidrich

Corrêa

et al. 2017

Mycoses

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Fusarium species have emerged as an important human pathogen in skin disease, onychomycosis, keratitis and invasive disease. Onychomycosis caused by Fusarium spp. The infection has been increasingly described in the immunocompetent and immunosuppressed hosts. Considering onychomycosis is a difficult to treat infection, and little is known about the genetic variability and susceptibility pattern of Fusarium spp., further studies are necessary to understand the pathogenesis and better to define the appropriate antifungal treatment for this infection. Accordingly, the objective of this study was to describe the in vitro susceptibility to different antifungal agents and the genetic diversity of 35 Fusarium isolated from patients with onychomycosis. Fusarium spp. were isolated predominantly from female Caucasians, and the most frequent anatomical location was the nail of the hallux. Results revealed that 25 (71.4%) of isolates belonged to the Fusarium solani species complex, followed by 10 (28.5%) isolates from the Fusarium oxysporum species complex. Noteworthy, the authors report the first case of Neocosmospora rubicola isolated from a patient with onychomycosis. Amphotericin B was the most effective antifungal agent against the majority of isolates (60%, MIC ≤4 μg/mL), followed by voriconazole (34.2%, MIC ≤4 μg/mL). In general, Fusarium species presented MIC values >64 μg/mL for fluconazole, itraconazole and terbinafine. Accurate pathogen identification, characterisation and susceptibility testing provide a better understanding of pathogenesis of Fusarium in onychomycosis.

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Section: Discussionmentioning

confidence: 99%

Genetic diversity and antifungal susceptibility of Fusarium isolates in onychomycosis

Rosa

Heidrich

Corrêa

et al. 2017

Mycoses

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“…described a case of congenital onychomycosis in a child caused by F. oxysporum . The infection was hypothetically acquired in utero , and this was proven after identification of the fungus by molecular methods in both the nails and placenta, most probably as an ascending contamination/infection in an HIV‐positive, immunosuppressed mother …”

Section: Etiologymentioning

confidence: 99%

“…Tosti et al . report clinical manifestations in patients with onychomycosis caused by non‐dermatophyte moulds resulting in proximal subungual nail alterations associated with painful periungual inflammation of the proximal nailfold, but disseminated infection has been described in immunosuppressed individuals . Special attention should be given to evaluating the nails of HIV‐exposed newborns with the objective of detecting any potentially life‐threatening fungal infections arising from onychomycosis …”

Section: Clinical Presentationmentioning

confidence: 99%

Onychomycosis in children. A review

Solís-Arias

García-Romero

2016

Int J Dermatology

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Onychomycosis is considered an age-related infection with increasing prevalence in the older age groups. It is rare in the pediatric population, except in children with Down syndrome and with immunodeficiencies, who are more likely to have fungal nail infections. The number of reports about onychomycosis in children is relatively small, and the epidemiologic data vary, but a rise in prevalence has been demonstrated. In this article, we review the most up-to-date literature and summarize the epidemiology, etiology, clinical presentation, diagnosis, and treatment of onychomycosis in children, as well as the differences with the disease presenting in adults. Dermatologists must consider onychomycosis in the differential diagnosis of nail alterations in children and always perform a mycological study to confirm the diagnosis.

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“…Onychomycosis is a common nail plate infection caused by dermatophytes, non-dermatophytic molds, and yeasts. The prevalence of this condition is low in children as compared to adults and even rarer in the newborn [1]. Nevertheless, this diagnosis cannot be excluded in children, and neonates are presenting with nail plate disorders.…”

Section: Introductionmentioning

confidence: 99%

Distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case

et al. 2019

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Background Onychomycosis is extremely rare in neonates, infrequently reported in children and is considered to be exclusively a disease of adults. Case presentation We, herein report a case of fingernail onychomycosis in a 28-day-old, healthy, male neonate. The child presented with a history of yellowish discoloration of the fingernail of the left hand for one week. The etiological agent was demonstrated both by microscopic examination and culture of nail clippings. The isolate grown on culture was identified as Candida albicans by phenotypic characteristics and by matrix-assisted laser desorption ionization-time of flight mass spectrometry. Antifungal sensitivity testing was performed by broth dilution method as per the Clinical & Laboratory Standards Institute guidelines. An oral swab culture of the child also yielded C. albicans with the same antibiogram as the nail isolate. The case was diagnosed as distal and lateral subungual candida onychomycosis of severity index score 22 (severe) and was treated with syrup fluconazole 6 mg/kg body weight/week and 5% amorolfine nail lacquer once/week for three months. After three months of therapy, the patient completely recovered with the development of a healthy nail plate. Conclusions The case is presented due to its rarity in neonates which, we suppose is the first case report of onychomycosis from Nepal in a 28-day-old neonate. Oral colonization with pathogenic yeasts and finger suckling could be risk factors for neonatal onychomycosis.

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Onychomycosis by Fusarium oxysporum probably acquired in utero

Cited by 11 publications

References 17 publications

Genetic diversity and antifungal susceptibility of Fusarium isolates in onychomycosis

Genetic diversity and antifungal susceptibility of Fusarium isolates in onychomycosis

Onychomycosis in children. A review

Distal and lateral subungual onychomycosis of the finger nail in a neonate: a rare case

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