Onychomycoses Due to Non-dermatophytic Molds

Maddy, Austin J.; Abrahams, Jennifer; Tosti, Antonella

doi:10.1007/978-3-319-44853-4_7

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Moulds can frequently inhabit the nails and are isolated as harmless contaminants in microbiology laboratories. However, they can also invade the nails and cause onychomycosis, and the prevalence of mould infections has been increasing worldwide for the past several decades 1) . Although onychomycosis caused by non-dermatophytes occurs at varying frequency according to geographic location, in developed countries, approximately 10% of onychomycoses are caused by non-dermatophyte moulds 2,3) .…”

Section: Introductionmentioning

confidence: 99%

Non-dermatophyte Mould Onychomycosis in Japan

Noguchi

Matsumoto

Kimura

et al. 2020

Medical Mycology Journal

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The incidence of non-dermatophyte mould onychomycosis has been increasing worldwide for the past several decades, but it is not well recognized in Japan. Recent molecular techniques and phylogenetic analyses contributed to the identification of uncommon and emerging species. We came across 13 (0.5%) cases of non-dermatophyte onychomycosis among a total of 2,591 onychomycosis cases in 106,703 outpatients during the past 5 years (January 2015-December 2019). The cases included 5 patients with Aspergillus species, 4 patients with Fusarium species, and one patient each with Scopulariopsis brevicaulis and Botryosphaeria dothidea, respectively. Botryosphaeria dothidea is closely related phylogenetically to Neoscytalidium dimidiatum. In Japan, at the time of writing this report, there are 26 reported cases of ungual aspergillosis and 18 cases of hyalohyphomycosis caused by Fusarium species. We summarize these cases and report the symptoms and mycological features.

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Section: Introductionmentioning

confidence: 99%

Non-dermatophyte Mould Onychomycosis in Japan

Noguchi

Matsumoto

Kimura

et al. 2020

Medical Mycology Journal

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“…Most of these organisms were opportunistic moulds. Studies have shown that the most common presentation of primary cutaneous infection from opportunistic fungi include mould onychomycosis with paronychia of the fingers and toes . Fusarium and Aspergillus are the most common pathogens …”

Section: Discussionmentioning

confidence: 99%

Dermatological manifestations of fungal infection in patients with febrile neutropaenia: A review of the literature

Maddy

Sanchez

Shukla

2019

Mycoses

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Summary Febrile neutropaenia (FNP) is a common cause of morbidity and mortality in immunocompromised patients. Although most infections are caused by bacterial pathogens, fungal infections are becoming increasingly more common. Due to its rarity, the diagnosis of fungal infections in febrile neutropenic patients is often delayed. To provide current clinical features, epidemiology, aetiology, diagnosis and treatment of cutaneous involvement of fungal infection in patients with FNP. A retrospective literature review of PubMed was performed, with no language or publishing data restrictions, yielding 116 results. We queried each case for cutaneous lesions associated with fungal pathogens in FNP. We found 54 publications with 215 reported cases of cutaneous manifestations of fungal injury in patients with FNP. This study is limited in that it is a literature review of a disease that is likely underreported. Cutaneous lesions caused by yeasts such as Candida and Trichosporon manifest as diffuse erythematous papules and usually do not develop central necrosis or eschar, while moulds will present as tender nodules that subsequently develop eschar and necrosis. Recognising the cutaneous manifestations of fungal disease can assist in the diagnosis and management of these infections.

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Distal Lateral Subungual Onychomycosis Owing to Tritirachium oryzae: A Bystander or Invader?

et al. 2017

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The genus Tritirachium is a mitosporic fungus which inhabits in soil and decaying plant material and also a notable insect pathogen. Human infections with Tritirachium species though rare were previously reported to cause corneal ulcers, otomycosis, onychomycosis, and dermatomycosis of the scalp and hence may be considered as a potential pathogen. Here we report a case of distal lateral subungual onychomycosis involving right great toenail in a 22-year-old female, wherein direct potassium hydroxide preparations, fungal cultures, and molecular sequencing of the isolate established Tritirachium oryzae as the etiological agent. Antifungal susceptibility performed by the microbroth technique of CLSI revealed increased MICs to amphotericin B and low MICs to azoles and echinocandins. The case was managed with surgical nail avulsion followed by topical application of 2% ketoconazole cream resulting regrowth of normal nail. To the best of our knowledge, this is the first report of non-dermatophytic mold T. oryzae causing onychomycosis in India.

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Onychomycoses Due to Non-dermatophytic Molds

Cited by 3 publications

References 41 publications

Non-dermatophyte Mould Onychomycosis in Japan

Non-dermatophyte Mould Onychomycosis in Japan

Dermatological manifestations of fungal infection in patients with febrile neutropaenia: A review of the literature

Distal Lateral Subungual Onychomycosis Owing to Tritirachium oryzae: A Bystander or Invader?

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