“…Issues of database size, diversity, and representation (both in the sense of race/ethnicity and cases/controls), population structure, and cryptic relatedness must be considered (National Research Council (US) Committee, 1996 ). Fisher et al created Ontology of RNA Sequencing ( ORNASEQ ) to capture, annotate, and manage provenance stores from RNA‐seq studies (Fisher & Kim, 2018 ) (Table 1 ). We must also acknowledge, and attempt to address, limitations (e.g., the half‐life/stability of RNA) and potential confounders (e.g., temporal changes in RNA expression, differences in RNA capture from fresh frozen vs. formalin‐fixed paraffin‐embedded samples, and phenomena like clonal hematopoiesis of indeterminate potential in liquid biopsies) (Wang et al, 2020 ).…”