Ontogeny of vasoactive intestinal peptide and somatostatin in different structures of the rat brain: effects of hypo- and hypercorticism

Nobou, Ferdinand; Besson, J.; Rostène, William; Rosselin, G

doi:10.1016/0165-3806(85)90118-x

Cited by 40 publications

(7 citation statements)

References 28 publications

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“…The curious findings in avian studies that involve mapping cell bodies that show VIP-like-ir using ICC are the few neurons detected in the cortex (Kuenzel and Blä hser, 1994;Aste et al, 1995;Bottjer and Alexander, 1995). In contrast, both radioimmunoassay (Emson et al, 1979;McGregor et al, 1982;Nobou et al, 1985) and ICC (Fuxe et al, 1977;Lorén et al, 1979;Morrison et al, 1984;Abrams et al, 1985) studies have shown that the cerebral cortex of mammals contains very high quantities of VIP and VIP-like neurons.…”

Section: Key Differences Obtained Between Icc and Ishh Or Between Avimentioning

confidence: 86%

Sites of gene expression for vasoactive intestinal polypeptide throughout the brain of the chick (Gallus domesticus)

et al. 1997

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The peptide neurotransmitter vasoactive intestinal polypeptide (VIP) has several important functions in vertebrates, particularly, influencing the neuroendocrine and autonomic nervous systems both in developing and in adult animals. To document potential brain areas that might play significant functional roles, the distribution of VIP mRNA was examined throughout the entire chick brain by using in situ hybridization histochemistry (ISHH). In addition, a VIP binding-site study was completed that focused on the lateral septal organ (LSO), a circumventricular organ of potential significance in avian species. The areas where VIP message was found included the olfactory bulbs, posterior hippocampus, parahippocampal area, hyperstriatum, archistriatum/nucleus (n.) taenia (amygdala), medial part of the LSO, organum vasculosum of the lamina terminalis, medial preoptic region, bed n. of the pallial commissure, anterior hypothalamic (hypo.) n., lateral hypo. area (most extensive and dense message), periventricular hypo. n., lateral to the paraventricular n., ventromedial hypo. n., stratum cellulare externum, inferior hypo. n., infundibular hypo. n., median eminence, three layers within the stratum griseum et fibrosum superficiale, area ventralis of Tsai, n. tegmenti pedunculopontinus pars compacta (substantia nigra), intercollicular n., central gray, locus ceruleus, parabrachial n., ventrolateral medulla, reticular pontine area, in and about the n. vestibularis descendens. When compared with immunocytochemistry that detected the presence of the peptide product VIP, more areas of the brain were found to contain perikarya expressing VIP by using ISHH, particularly in the telencephalon and the mesencephalon. VIP binding sites were found in the lateral portion of the LSO where the blood-brain barrier is not fully developed. Hence, the LSO was found to contain neural elements that synthesize as well as bind VIP. VIP appears to be a useful peptide for defining major components of the visceral forebrain system in birds.

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Section: Key Differences Obtained Between Icc and Ishh Or Between Avimentioning

confidence: 86%

Sites of gene expression for vasoactive intestinal polypeptide throughout the brain of the chick (Gallus domesticus)

et al. 1997

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“…VIP was later found to be a widely distributed neuropeptide with neurotransmitter, neuromodulator and neurohormone functions [22], Ontogénie studies of VIP by radioimmunoassays suggest that VIP mainly appears in the postnatally developing animal, with high concentrations in specific brain structures such as the cerebral cortex, the hypothalamus and the hippocampus [6,16,19]. Our studies suggest that the postnatal increase in VIP content in the brain is regulated at the level of gene expression [8,13].…”

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confidence: 90%

Vasoactive Intestinal Peptide Gene Expression from Embryos to Aging Rats

et al. 1988

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Vasoactive intestinal peptide (VIP) gene transcripts were demonstrated by RNA blot hybridization using VIP-specific RNA hybridization probes. High levels of expression were observed as early as in 16-day-old embryos. In aging rats, the VIP-mRNA levels were reduced significantly (in the cerebral cortex) as compared to 21-day-old rats. Our results suggest a role for the VIP gene protein products during embryonal development. During aging processes the decrease in VIP gene transcripts may be a consequence of either a reduction in the transcriptional activity of VIP neurons or death of VIP-producing cells.

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“…Perhaps the only controversial issue in this respect is the time of first appearance of cortical VIP cells. Authors, however, concur that in the rat, VIP is a relatively late appearing peptide, and the problem of its earliest histochemical demonstration is merely technical (McDonald et al 1982;Nobou et al 1985;Cavanagh and Parnavelas 1989). We regard therefore, the fact that we were able to point out cortical VIP cells as early as on PI, i.e., earlier than demonstrated by others (Emson et al 1979;McDonald et al 1982;Cavanagh and Parnavelas 1989) important as proving the sensitivity of the procedure used by us.…”

Section: Discussionmentioning

confidence: 53%

Vasoactive intestinal polypeptide (VIP) containing cells in the developing rat occipital hemisphere

1990

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Numerous cells were observed to show intense vasoactive intestinal polypeptide (VIP) immunoreactivity from birth to postnatal day 8 in the subventricular zone of the rat occipital hemisphere. This cell population was markedly reduced by postnatal day 8, but isolated clusters of VIP cells persisted into adulthood. In addition, long, L-shaped VIP fibers were seen in the hemispheric wall up to postnatal day 16, but not in the adult. Parallel to the reduction in number of the subventricular VIP cells an increasing number of VIP cells appeared in the neo- and allocortex, developing by postnatal day 12 all the features of the mature cortical bipolar fusiform neurons. As possible alternatives, the migration of subventricular VIP cells into the cortex, the transient character of the subventricular VIP population or the expression of VIP by radial glia are discussed.

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Ontogeny of vasoactive intestinal peptide and somatostatin in different structures of the rat brain: effects of hypo- and hypercorticism

Cited by 40 publications

References 28 publications

Sites of gene expression for vasoactive intestinal polypeptide throughout the brain of the chick (Gallus domesticus)

Sites of gene expression for vasoactive intestinal polypeptide throughout the brain of the chick (Gallus domesticus)

Vasoactive Intestinal Peptide Gene Expression from Embryos to Aging Rats

Vasoactive intestinal polypeptide (VIP) containing cells in the developing rat occipital hemisphere

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