Ontogeny of the corticotropin-releasing factor system in zebrafish

Alderman, Sarah L.; Bernier, Nicholas J.

doi:10.1016/j.ygcen.2009.04.007

Cited by 157 publications

(124 citation statements)

References 63 publications

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“…Cortisol concentrations and mRNA abundance of HPI axis genes have been well characterized throughout development in zebrafish (Alsop and Vijayan, 2008;Alderman and Bernier, 2009;Wilson test was used to evaluate the effect of maternal social status on the production of a viable clutch. Maternal cortisol levels as well as maternal treatment effects on embryo size, survival at 24 hpf, hatching, baseline or stress-induced cortisol levels, and mRNA abundance were analysed by one-way ANOVA.…”

Section: Discussionmentioning

confidence: 99%

“…Ontogeny of the hypothalamic-pituitary-interrenal (HPI) axis has been well studied in zebrafish (Alsop and Vijayan, 2008;Alderman and Bernier, 2009;Wilson et al, 2013), providing the necessary groundwork for investigating effects of maternal social stress. Specific maternal mRNAs associated with the HPI axis are transferred to eggs and play a key role in embryogenesis before embryos begin to synthesize mRNAs (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…become transcriptionally active). Transcripts for crf, its binding protein and its receptors are present in eggs; however, their role in early development remains unclear (Alderman and Bernier, 2009). Maternal gr transcripts mediate cortisol-dependent actions during early development (Nesan and Vijayan, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…As embryos become transcriptionally active, mRNA abundance of HPI axis genes increases (Alsop and Vijayan, 2009). At this point, zebrafish larvae possess all of the machinery necessary to synthesize cortisol de novo, and by 72 h postfertilization (hpf), they begin to respond to stressors with an increase in cortisol levels (Alderman and Bernier, 2009;Wilson et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

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Programming of the hypothalamic-pituitary-interrenal axis by maternal social status in zebrafish (Danio rerio)

Jeffrey

Gilmour

2016

Journal of Experimental Biology

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The present study examined the effects of maternal social status, with subordinate status being a chronic stressor, on development and activity of the stress axis in zebrafish embryos and larvae. Female zebrafish were confined in pairs for 48 h to establish dominant/subordinate hierarchies; their offspring were reared to 144 hours post-fertilization (hpf) and sampled at five time points over development. No differences were detected in maternal cortisol contribution, which is thought to be an important programmer of offspring phenotype. However, once zebrafish offspring began to synthesize cortisol de novo (48 hpf), larvae of dominant females exhibited significantly lower baseline cortisol levels than offspring of subordinate females. These lower cortisol levels may reflect reduced hypothalamic-pituitary-interrenal (HPI) axis activity, because corticotropin-releasing factor (crf) and cytochrome p450 side chain cleavage enzyme (p450scc) mRNA levels also were lower in larvae from dominant females. Moreover, baseline mRNA levels of HPI axis genes continued to be affected by maternal social status beyond 48 hpf. At 144 hpf, stress-induced cortisol levels were significantly lower in offspring of subordinate females. These results suggest programming of stress axis function in zebrafish offspring by maternal social status, emphasizing the importance of maternal environment and experience on offspring stress axis activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Programming of the hypothalamic-pituitary-interrenal axis by maternal social status in zebrafish (Danio rerio)

Jeffrey

Gilmour

2016

Journal of Experimental Biology

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“…CRF has been implicated in mediating stress-related response in the hypothalamic-pituitaryinterrenal (HPI) axis, stimulating the secretion of adrenocorticotropin hormone (ACTH) from pituitary, which in turn results in adrenal release of glucocorticoids, including cortisol (Mommsen et al, 1999). A recent study suggested that the HPI axis is active and responsive to stressors very early (by 3 dpf) in zebrafish (Alderman and Bernier, 2009). Therefore, the increased up-regulation of CRH gene expression in our study could also be a non-specific stress response in zebrafish larvae.…”

Section: Discussionmentioning

confidence: 50%

Waterborne exposure to PFOS causes disruption of the hypothalamus–pituitary–thyroid axis in zebrafish larvae

et al. 2009

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Identification and characterization of a novel corticotropin‐releasing hormone‐binding protein (CRH‐BP) gene from Chinese honeybee (Apis cerana cerana)

Liu

Meng

et al. 2011

Arch Insect Biochem Physiol

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Corticotropin-releasing hormone-binding protein (CRH-BP) is an essential secreted glycoprotein for coordinating the neuroendocrine responses to stress by binding either CRHs or its related peptides. A novel CRH-BP gene AccCRH-BP from Apis cerana cerana was identified and characterized. Its genomic DNA was consisted of seven exons and six introns, and shared high similarity with the homologous members from other insects and vertebrates. Homologous and phylogenetic analysis indicated that AccCRH-BP was highly conserved, suggesting the maintenance of conservative structure might be necessary for its biological function. Real-time quantitative PCR revealed that AccCRH-BP was highly expressed in pupa and adult, especially in the head of pupa. However, there was no expression in larval stage. Furthermore, the transcripts of AccCRH-BP in the brain of honeybees were induced by exposure to environmental stresses including UV-light, heat, and cold. The expression level of AccCRH-BP in workers or queens was significantly higher than that of drones. Additionally, analysis of 5'-flanking region of AccCRH-BP revealed a number of putative development and stress transcription factor-binding sites. These data suggest that AccCRH-BP may play important roles in the regulation of honeybee development, and in the central nervous system of the brain to regulate the neuroendocrine stress responses.

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Ontogeny of the corticotropin-releasing factor system in zebrafish

Cited by 157 publications

References 63 publications

Programming of the hypothalamic-pituitary-interrenal axis by maternal social status in zebrafish (Danio rerio)

Programming of the hypothalamic-pituitary-interrenal axis by maternal social status in zebrafish (Danio rerio)

Waterborne exposure to PFOS causes disruption of the hypothalamus–pituitary–thyroid axis in zebrafish larvae

Identification and characterization of a novel corticotropin‐releasing hormone‐binding protein (CRH‐BP) gene from Chinese honeybee (Apis cerana cerana)

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