Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development

Haynes, Barton F.; Denning, Stephen M.; Singer, Kay H.; Kurtzberg, Joanne

doi:10.1016/0167-5699(89)90232-6

Cited by 202 publications

(87 citation statements)

References 17 publications

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“…Kondoet al more recently reported the direct evidence for the existence of commonlymphoid progenitors (CLPs) that could differentiate into only T cells, B cells, and NKcells, in the sites where early hematopoiesis was seen in mice (40). In the current study, patients' blasts apparently correspond to prothymocyte stage I (pro-T I) in T-cell development proposed by Haynes et al (35). The Pro-T population probably includes a small fraction of CLPs (41,42).…”

Section: Discussionmentioning

confidence: 65%

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CD56+ CD7+ Stem Cell Leukemia/Lymphoma with D2-J.DELTA.1 Rearrangement.

et al. 1999

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Section: Discussionmentioning

confidence: 65%

“…In the present study, we have described three cases of Functionally, a subset of pro-T cells is thought to be multipotent (35). In fact, we experienced that T-stem cell leukemia/lymphoma of pro-T I or II cells were transformed to AMLwith positive MPOin relapse.…”

Section: Discussionmentioning

confidence: 88%

CD56+ CD7+ Stem Cell Leukemia/Lymphoma with D2-J.DELTA.1 Rearrangement.

et al. 1999

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“…Knowledge about T cell differentiation and the associated immunophenotypes is increasing rapidly. [1][2][3] Originating from lymphoid stem cells in the bone marrow (BM), T precursor cells migrate to the thymus. In the thymic cortex cells acquire a CD1 + and/or CD4 + CD8 + double-positive (DP) phenotype that is associated with a unique biology.…”

Section: Introductionmentioning

confidence: 99%

A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies

et al. 1999

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During T cell selection in the thymic cortex more than 90% of the thymocytes are eliminated by apoptosis. Based on this biology, we propose to define blasts of T cell acute lymphoblastic leukemia (ALL) with the phenotype of cortical thymocytes (CD1 ؉ and/or CD4 ؉ 8 ؉ ) as selection-related (SR) and all other T-ALL immunophenotypes as non-selection-related (NSR). The COALL cooperative treatment studies for childhood ALL offer a tool to study the outcome in T-ALL subgroups as children with T-ALL are allocated uniformly to the high risk arm of the protocol. In the COALL-85, -89 and -92 protocols, 39/83 cases presented as SR and 44/83 cases as NSR. Five-year event-free survival of SR phenotype is significantly better compared to the NSR group (0.87 ± 0.06 vs 0.66 ± 0.07, log rank test, P = 0.01). T-ALL with SR phenotype is a distinct subgroup of leukemia with excellent prognosis under a high risk treatment protocol.

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“…Thymocyte precursor cells begin their differentiation and education process as T-cell receptor-b alterations in otosclerosis I Schrauwen et al (CD3 þ )CD4 À CD8 À or DN cells and subsequently become double-positive (CD3 þ )CD4 þ CD8 þ thymocytes. 30 Finally, after positive and negative selection, these T-cell precursor cells differentiate into single-positive T cells (CD3 þ CD4 À CD8 þ or CD3 þ CD4 þ CD8 À ) and migrate to the periphery. In the peripheral blood of otosclerosis OTSC2 patients, there was a significantly increased frequency of DN T cells and a decreased percentage of CD4 single-positive T cells.…”

Section: Discussionmentioning

confidence: 99%

Involvement of T-cell receptor-β alterations in the development of otosclerosis linked to OTSC2

et al. 2010

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Otosclerosis is a common form of hearing loss, characterized by disordered bone remodeling in the otic capsule. Within the otosclerotic foci, several immunocompetent cells and immune-modulating factors can be found. Different etiological theories involving the immune system have been suggested. However, a genetic component is clearly present. In large otosclerosis families, seven autosomal-dominant loci have been found, but none of the disease-causing genes has been identified. This study focused on the exploration of the second otosclerosis locus on chromosome 7q34-36 (OTSC2), holding the T-cell receptor beta locus (TRB locus). A significantly lower T-cell receptor-b (TCR-b) mRNA expression and percentage of blood circulating TCR-ab þ T cells was detected in OTSC2 patients compared with controls and patients with the complex form of the disease. Further analysis illustrated more significant disturbances in specific T-cell subsets, including an increased CD28 null cell population, suggesting a disturbed T-cell development and ageing in OTSC2 patients. These disturbances could be associated with otosclerotic bone remodeling, given the known effects of immunocompetent cells on bone physiology. These data implicate the TRB locus as the causative gene in the OTSC2 region and represent an important finding in the elucidation of the disease pathology.

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Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development

Cited by 202 publications

References 17 publications

CD56+ CD7+ Stem Cell Leukemia/Lymphoma with D2-J.DELTA.1 Rearrangement.

CD56+ CD7+ Stem Cell Leukemia/Lymphoma with D2-J.DELTA.1 Rearrangement.

A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies

Involvement of T-cell receptor-β alterations in the development of otosclerosis linked to OTSC2

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