Ontogeny of methamphetamine-induced and cocaine-induced one-trial behavioral sensitization in preweanling and adolescent rats

Kozanian, Olga O.; Gutierrez, Arnold; Mohd-Yusof, Alena; McDougall, Sanders A.

doi:10.1097/fbp.0b013e32835651c9

Cited by 15 publications

(19 citation statements)

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“…In a series of studies, we previously reported that young rats show strong one-trial behavioral sensitization, but the age at which sensitized responding was exhibited depended on the psychostimulant being administered (McDougall et al 2011a, 2013; Kozanian et al 2012). For example, amphetamine and METH caused the most robust sensitized responding at PD 13 and PD 17, while cocaine only produced behavioral sensitization in older animals (i.e., at PD 21).…”

Section: Discussionmentioning

confidence: 99%

“…Ontogenetic studies examining the preweanling period have shown that cocaine-induced one-trial behavioral sensitization is strongest when assessed around PD 21, whereas METH- and amphetamine-induced one-trial sensitization is most robust at PD 17 (Kozanian et al 2012; McDougall et al 2013). Cocaine and METH sensitization was either weak or not evident at the opposing ages (Kozanian et al 2012).…”

Section: Methodsmentioning

confidence: 99%

“…Cocaine and METH sensitization was either weak or not evident at the opposing ages (Kozanian et al 2012). In the present study, therefore, cocaine-induced behavioral sensitization was assessed on PD 20–21, while METH- and NPA-induced sensitization was assessed on PD 16–17 ( N = 48 for each agonist condition).…”

Section: Methodsmentioning

confidence: 99%

“…In contrast to adult rats, however, the one-trial behavioral sensitization of preweanling rats is context-independent, since the sensitized responding of young rats is equally robust if drug pretreatment occurs in the test chamber, home cage, or a separate novel compartment (McDougall et al 2009b, 2011b; Herbert et al 2010). In preweanling rats, the context-independent nature of one-trial behavioral sensitization has been shown using cocaine, amphetamine, and METH (Kozanian et al 2012; McDougall et al 2013). The neural mechanisms mediating behavioral sensitization during early ontogeny, including the role of the D1 receptor, have seldom been studied in the preweanling rat (for an exception, see Duke et al 1997).…”

Section: Introductionmentioning

confidence: 99%

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Role of the D1 receptor for the dopamine agonist-induced one-trial behavioral sensitization of preweanling rats

et al. 2014

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Rationale The neural mechanisms mediating the ontogeny of behavioral sensitization are poorly understood. Objective The purpose of the present study was to determine the role of the D1 receptor for the induction of dopamine agonist-induced behavioral sensitization during the preweanling period. Methods In the first experiment, the early ontogeny of NPA-induced behavioral sensitization was examined by pretreating male and female rats with saline or NPA (0.5, 1, or 2 mg/kg, IP) before placement in activity chambers on postnatal day (PD) 12, 16, 20, or 24. One day later, rats were tested with lower doses of NPA and the occurrence of locomotor sensitization was determined. In subsequent experiments, rats were injected with saline or the D1 receptor antagonist SCH23390 (0.1, 0.5, 1, or 5 mg/kg, IP) 0, 15, 30, or 60 min before cocaine, methamphetamine (METH), or NPA pretreatment. The next day, rats were tested with the same dopamine agonist again and sensitized responding was assessed. Results NPA produced one-trial behavioral sensitization at all ages tested. In preweanling rats, SCH23390, regardless of dose, was ineffective at preventing the induction of cocaine-, METH-, or NPA-induced one-trial behavioral sensitization. Conclusions The present results are in partial contrast to adult rodent studies, in which SCH23390 blocks the induction of METH- and apomorphine-induced behavioral sensitization, but not cocaine sensitization. When these findings are considered together, it appears that D1 receptor stimulation is not necessary for the induction of behavioral sensitization during the preweanling period, although D1 receptors may play a more important role in adulthood.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of the D1 receptor for the dopamine agonist-induced one-trial behavioral sensitization of preweanling rats

et al. 2014

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“…This is consistent with some, but not all, previous studies. A study (Kozanian, Gutierrez, Mohd‐Yusof, & McDougall, 2012) found, albeit using stimulants other than AMPH or MPH, a sensitized response to the repeated administration of methamphetamine or cocaine in preweanling, but not in adolescent, rats. Conversely, adolescent but not adult mice exhibited greater motor activity to a challenge dose of AMPH (2.0 mg/kg), after a history of exposure to 10.0 mg/kg AMPH (Adriani et al., 1998).…”

Section: Discussionmentioning

confidence: 99%

Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats

et al. 2018

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IntroductionThere has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention‐deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur.MethodsThis study assessed the effects of repeated d‐amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40).ResultsAmphetamine and MPH exerted reliable acute motor stimulant effects, but there was no indication of sensitized motor or anxiety responses. MPH did not affect dopamine (DA) levels, whereas AMPH significantly reduced insular levels of DA in both sexes and norepinephrine levels in females only. Repeated treatment with AMPH, but not with MPH, enhanced ethanol intake during late adolescence in male, but not in female, rats.ConclusionA short treatment with AMPH during adolescence significantly altered DA levels in the insula, both in male and females, and significantly enhanced ethanol intake in males. The present results suggest that, in adolescent males, a very brief history of AMPH exposure can facilitate the initiation of ethanol intake.

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Age‐dependent effects of dopamine receptor inactivation on cocaine‐induced behaviors in male rats: Evidence of dorsal striatal D2 receptor supersensitivity

Crawford

Teran

Ramirez

et al. 2019

J of Neuroscience Research

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N‐ethoxycarbonyl‐2‐ethoxy‐1,2‐dihydroquinoline (EEDQ), which irreversibly inactivates dopamine (DA) receptors, causes pronounced age‐dependent behavioral effects in rats. For example, EEDQ either augments or does not affect the DA agonist‐induced locomotor activity of preweanling rats while attenuating the locomotion of adolescent and adult rats. The twofold purpose of this study was to determine whether EEDQ would: (a) potentiate or attenuate the cocaine‐induced locomotor activity of preweanling, adolescent, and adult rats; and (b) alter the sensitivity of surviving D2 receptors. Rats were treated with vehicle or EEDQ (2.5 or 7.5 mg/kg) on postnatal day (PD) 17, PD 39, and PD 84. In the behavioral experiments, saline‐ or cocaine‐induced locomotion was assessed 24 hr later. In the biochemical experiments, dorsal striatal samples were taken 24 hr after vehicle or EEDQ treatment and later assayed for NPA‐stimulated GTPγS receptor binding, G protein‐coupled receptor kinase 6 (GRK6), and β‐arrestin‐2 (ARRB2). GTPγS binding is a direct measure of ligand‐induced G protein activation, while GRK6 and ARRB2 modulate the internalization and desensitization of D2 receptors. Results showed that EEDQ potentiated the locomotor activity of preweanling rats, while attenuating the locomotion of older rats. NPA‐stimulated GTPγS binding was elevated in EEDQ‐treated preweanling rats, relative to adults, indicating enhanced functional coupling between the G protein and receptor. EEDQ also reduced ARRB2 levels in all age groups, which is indicative of increased D2 receptor sensitivity. In sum, the present results support the hypothesis that D2 receptor supersensitivity is a critical factor mediating the locomotor potentiating effects of EEDQ in cocaine‐treated preweanling rats.

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Ontogeny of methamphetamine-induced and cocaine-induced one-trial behavioral sensitization in preweanling and adolescent rats

Cited by 15 publications

References 64 publications

Role of the D1 receptor for the dopamine agonist-induced one-trial behavioral sensitization of preweanling rats

Role of the D1 receptor for the dopamine agonist-induced one-trial behavioral sensitization of preweanling rats

Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats

Age‐dependent effects of dopamine receptor inactivation on cocaine‐induced behaviors in male rats: Evidence of dorsal striatal D2 receptor supersensitivity

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