Ontogeny of estrogen receptors in human male and female fetal reproductive tracts

Cunha, Gerald R.; Li, Yang; Cao, Mei; Derpinghaus, Amber; Baskin, Laurence S.

doi:10.1016/j.diff.2020.10.001

Cited by 8 publications

(7 citation statements)

References 118 publications

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“…Fetal gonadotrophins are suppressed at term because of the increased sensitivity to circulating estrogens [45]. In preterm infants, the high gonadotrophin at birth become suppressed around 38-42 weeks' gestation, possibly due to hypothalamic maturation which enables suppression by rising neonatal ovarian estrogens [44].…”

Section: The Developing Uterus and The Effect Of Steroidsmentioning

confidence: 99%

“…The fetal compartment is characterized by extensive conjugation of steroids to their sulfate that blocks their biological effect [42, 43]. The fetal adrenal-placental axis determines estrogen levels and this, in turn, influences progesterone production [44].…”

Section: The Developing Uterus and The Effect Of Steroidsmentioning

confidence: 99%

“…Receptor knock-out mice (ERα/ESR1-KO and ERβ/ESR2-KO mice) possess all definitive uterine compartments but ESR1-KO mice feature hypoplastic uteri whereas ESR2-KO mice uteri appear normal. The luminal and glandular epithelium in the ESR1-KO uterus appear healthy, but the epithelium is cuboidal rather than tall columnar as seen in the normal estrogenized morphology [44, 45].…”

Section: The Developing Uterus and The Effect Of Steroidsmentioning

confidence: 99%

“…Late estrogen exposure manifests in the formation of breast nodules, milk production, and proliferation of the vaginal epithelium. Cunha et al [44], studied samples of fetal uteri obtained between 8 and 22 weeks gestation and found that ESR1 is first expressed in the mesenchyme of the developing uterus but not the epithelium at 12 weeks of gestation. At 21 weeks, the uterine lumen is lined by ESR1-negative (ESR1-ve) epithelial cells.…”

Section: The Developing Uterus and The Effect Of Steroidsmentioning

confidence: 99%

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In Memory of Ivo Brosens: Reflections on the Pathophysiology of Neonatal Uterine Bleeding

Habiba¹,

Guo²,

Benagiano³

2023

Gynecol Obstet Invest

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Background: The occurrence of vaginal bleeding in early neonatal life has been observed for centuries and was considered a consequence of the sudden drop in circulating hormones following birth. As such, neonatal uterine bleeding was dismissed as having no clinical significance. Interest in the phenomenon was renewed when a new theory suggested a link between neonatal uterine bleeding (NUB) and accelerated endometrial maturation. This theory was based on the observation of a higher incidence of NUB in babies born post-term or after pregnancies complicated by intrauterine growth restriction, preeclampsia, or blood group incompatibility. Objective: The objective of this study was to review of available evidence on the pathogenesis of NUB. Method: Review of available literature using Medline search (August 2022, no limit on start date or language) to identify articles that may link NUB with features of the uterus and/or endometrium. Outcome: The fetal endometrial responses differ from that of the adult. In the fetus, the endometrium features progestogenic response only in a minority of cases. The endometrium in most newborn girls does not exhibit secretory or decidual changes which indicate lack of progesterone response. Most newborn girls do not have visible bleeding. Animal studies linked exogenous progestogen exposure during the period of organogenesis to poor endometrial gland development, progesterone resistance, and to alterations of reproductive performance. Although the fetal endometrium may not exhibit a full proliferative response, it is clearly sensitive to circulating estrogens. Molecular mechanisms involved in NUB may include “ontogenetic progesterone resistance.” Conclusion and Outlook: Endometrial development and its response to withdrawal of hormones at birth varies and may be affected by intrauterine stressors and gestational age. Factors that affect endometrial development during fetal life and in preterm neonates can have implications on future reproductive performance.

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Section: The Developing Uterus and The Effect Of Steroidsmentioning

confidence: 99%

Section: The Developing Uterus and The Effect Of Steroidsmentioning

confidence: 99%

Section: The Developing Uterus and The Effect Of Steroidsmentioning

confidence: 99%

Section: The Developing Uterus and The Effect Of Steroidsmentioning

confidence: 99%

See 2 more Smart Citations

In Memory of Ivo Brosens: Reflections on the Pathophysiology of Neonatal Uterine Bleeding

Habiba¹,

Guo²,

Benagiano³

2023

Gynecol Obstet Invest

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“…Those data were visualized with ENCODE 70 and RefSeq tracks on UCSC genome browser 71 . Slides from paraffin-embedded tissues of human UGS at 18 weeks were used for IHC analyses 72 .…”

Section: Human Dataset Analysismentioning

confidence: 99%

Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes

Kim

Olson

et al. 2022

Nat Commun

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Androgen/androgen receptor (AR) signaling pathways are essential for prostate tumorigenesis. However, the fundamental mechanisms underlying the AR functioning as a tumor promoter in inducing prostatic oncogenesis still remain elusive. Here, we demonstrate that a subpopulation of prostatic Osr1 (odd skipped-related 1)-lineage cells functions as tumor progenitors in prostate tumorigenesis. Single cell transcriptomic analyses reveal that aberrant AR activation in these cells elevates insulin-like growth factor 1 (IGF1) signaling pathways and initiates oncogenic transformation. Elevating IGF1 signaling further cumulates Wnt/β-catenin pathways in transformed cells to promote prostate tumor development. Correlations between altered androgen, IGF1, and Wnt/β-catenin signaling are also identified in human prostate cancer samples, uncovering a dynamic regulatory loop initiated by the AR through prostate cancer development. Co-inhibition of androgen and Wnt-signaling pathways significantly represses the growth of AR-positive tumor cells in both ex-vivo and in-vivo, implicating co-targeting therapeutic strategies for these pathways to treat advanced prostate cancer.

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Genetic, Epigenetic, and Anatomical Factors in Agenesis and Development of Female Reproductive Tract

Nakajima¹,

Satō²,

Iguchi³

2022

Genomic and Epigenomic Biomarkers of Toxicology and Disease

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Ontogeny of estrogen receptors in human male and female fetal reproductive tracts

Cited by 8 publications

References 118 publications

In Memory of Ivo Brosens: Reflections on the Pathophysiology of Neonatal Uterine Bleeding

In Memory of Ivo Brosens: Reflections on the Pathophysiology of Neonatal Uterine Bleeding

Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes

Genetic, Epigenetic, and Anatomical Factors in Agenesis and Development of Female Reproductive Tract

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