Ontogeny and Regional Distribution of Hormone-Producing Cells in the Embryonic Pancreas of Alligator mississippiensis

Jackintell, Lori A.; Lance, Valentine A.

doi:10.1006/gcen.1994.1081

Cited by 11 publications

(8 citation statements)

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“…The results of this study indicate that the PP (pancreatic polypeptide synthesizing and secreting) cells were found in the dorsal part of the embryonic pancreas of the grass snake at developmental stage XII for the first time. A similar late presence of pancreatic PP cells has also been described in Alligator mississippiensis (Jackintell & Lance, ) and chick embryos (Mikami et al, ). It can be supposed that the late appearance of these cells in the pancreas of the grass snake embryos is related to preparing the animal for life outside of the egg (Katsuura, Asakawa, &Inui, ).…”

Section: Discussionsupporting

confidence: 75%

“…They were the first pancreatic endocrine cells that differentiate in the pancreas anlage of the grass snake embryos. Such an early presence of pancreatic B cells in the embryonic pancreas has also been described in zebrafish (Biemar et al, ), frog (Kaung & Elde, ; Kaung, ; Ghaskadbi & Ghate, ; Milano & Chimenti, ; Kelly & Melton, ), green anole (Rhoten & Hall, ), alligator (Jackintell & Lance, ), chick (Przybylski, ; Pablo et al, ), rat (Pictet & Rutter, ), mouse (Herrera et al, ), and human (Piper et al, ) embryos. It can be assumed that early B cell differentiation in grass snake embryos is associated with high insulin requirements similar to other metazoans.…”

Section: Discussionmentioning

confidence: 64%

“…The time that the A cells appear in grass snake embryos is also different from that in American alligator (Jackintell & Lance, ), green anole (Rhoten & Hall, ), and chick (Cowap, ) embryos, where the A and B cells differentiate during the same embryonic period. Such an early appearance of A cells in the embryonic pancreas is thought to be related to the development of the embryos (Prasadan et al, ).…”

Section: Discussionmentioning

confidence: 94%

“…Differentiation of the D cells in the pancreas in most vertebrates starts later than other pancreatic endocrine cells. For example, they have been described in the pancreas primordium of the leopard frog (Kaung, ), Alligator mississippiensis (Jackintell & Lance, ) and chick (Pictet & Rutter, ) only after the appearance of the A and B cells. Quite a different situation has been described in the pancreatic bud of rat (Yoshinari & Daikoku, ) and mouse (Herrera et al, ) embryos, where the D cells appear as the last endocrine cells.…”

Section: Discussionmentioning

confidence: 99%

“…Glucagon is necessary for growth and cell differentiation during pancreas morphogenesis in vertebrate embryos (Prasadan et al, ). It is also probable that pancreatic hormones play a key role in the early developmental stages of reptilian sauropsids (Jackintell & Lance, ).…”

Section: Introductionmentioning

confidence: 99%

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Ultrastructure of endocrine pancreatic granules during pancreatic differentiation in the grass snake, Natrix natrix L. (Lepidosauria, Serpentes)

Kowalska

Rupik

2017

Journal of Morphology

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We used transmission electron microscopy to study the pancreatic main endocrine cell types in the embryos of the grass snake Natrix natrix L. with focus on the morphology of their secretory granules. The embryonic endocrine part of the pancreas in the grass snake contains four main types of cells (A, B, D, and PP), which is similar to other vertebrates. The B granules contained a moderately electron-dense crystalline-like core that was polygonal in shape and an electron-dense outer zone. The A granules had a spherical electron-dense eccentrically located core and a moderately electron-dense outer zone. The D granules were filled with a moderately electron-dense non-homogeneous content. The PP granules had a spherical electron-dense core with an electron translucent outer zone. Within the main types of granules (A, B, D, PP), different morphological subtypes were recognized that indicated their maturity, which may be related to the different content of these granules during the process of maturation. The sequence of pancreatic endocrine cell differentiation in grass snake embryos differs from that in many vertebrates. In the grass snake embryos, the B and D cells differentiated earlier than A and PP cells. The different sequence of endocrine cell differentiation in snakes and other vertebrates has been related to phylogenetic position and nutrition during early developmental stages.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ultrastructure of endocrine pancreatic granules during pancreatic differentiation in the grass snake, Natrix natrix L. (Lepidosauria, Serpentes)

Kowalska

Rupik

2017

Journal of Morphology

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Development of endocrine pancreatic islets in embryos of the grass snake Natrix natrix (Lepidosauria, Serpentes)

Kowalska

Rupik

2018

Journal of Morphology

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Differentiation of the pancreatic islets in grass snake Natrix natrix embryos, was analyzed using light, transmission electron microscopy, and immuno‐gold labeling. The study focuses on the origin of islets, mode of islet formation, and cell arrangement within islets. Two waves of pancreatic islet formation in grass snake embryos were described. The first wave begins just after egg laying when precursors of endocrine cells located within large cell agglomerates in the dorsal pancreatic bud differentiate. The large cell agglomerates were divided by mesenchymal cells thus forming the first islets. This mode of islet formation is described as fission. During the second wave of pancreatic islet formation which is related to the formation of the duct mantle, we observed four phases of islet formation: (a) differentiation of individual endocrine cells from the progenitor layer of duct walls (budding) and their incomplete delamination; (b) formation of two types of small groups of endocrine cells (A/D and B) in the wall of pancreatic ducts; (c) joining groups of cells emerging from neighboring ducts (fusion) and rearrangement of cells within islets; (d) differentiated pancreatic islets with characteristic arrangement of endocrine cells. Mature pancreatic islets of the grass snake contained mainly A endocrine cells. Single B and D or PP–cells were present at the periphery of the islets. This arrangement of endocrine cells within pancreatic islets of the grass snake differs from that reported from most others vertebrate species. Endocrine cells in the pancreas of grass snake embryos were also present in the walls of intralobular and intercalated ducts. At hatching, some endocrine cells were in contact with the lumen of the pancreatic ducts.

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Comparative Analysis of Islet Development

Poudel

Savari

Tekin

et al. 2016

Pancreatic Islet Biology

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Ontogeny and Regional Distribution of Hormone-Producing Cells in the Embryonic Pancreas of Alligator mississippiensis

Cited by 11 publications

References 0 publications

Ultrastructure of endocrine pancreatic granules during pancreatic differentiation in the grass snake, Natrix natrix L. (Lepidosauria, Serpentes)

Ultrastructure of endocrine pancreatic granules during pancreatic differentiation in the grass snake, Natrix natrix L. (Lepidosauria, Serpentes)

Development of endocrine pancreatic islets in embryos of the grass snake Natrix natrix (Lepidosauria, Serpentes)

Comparative Analysis of Islet Development

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