Ontogenic Study on the Bronchus-Associated Lymphoid Tissue (Balt) in the Rat, with Special Reference to Dendritic Cells

Matsuura, Yoshifusa; Imazeki, Nobuo; Senoo, Akira; Fuse, Yusuke

doi:10.1007/978-1-4615-2930-9_74

Cited by 1 publication

(3 citation statements)

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“…Our findings of S-100 protein-immunoreactive dendritic-like cells in the anal tonsil of the laboratory shrew are consistent with the fact that dendritic cells of the thymus, lymph nodes, and bronchusassociated lymphoid tissue exhibit S-100 immunoreactivity (Gaillard et al, 1993;Matsuura et al, 1992;Sugimura et al, 1990;Uccini et al, 1986). We suggest that these dendritic-like cells located in the B cell area are identical to follicular dendritic cells (FDC) based on their spine-like morphology and location (Cocchia et al, 1983;Humphrey et al, 1984).…”

Section: Discussionsupporting

confidence: 89%

“…Antibovine S-100 protein rabbit sera were commercially purchased from DAKO (Z0311, Denmark). The specificity of this antibody for the S-100 protein of dendritic cells is described elsewhere (Gaillard et al, 1993;Matsuura et al, 1992;Sugimura et al, 1990;Uccini et al, 1986).…”

Section: Antiseramentioning

confidence: 99%

“…Dendritic cells were further identified by their reactivity with an antiserum to the S-100 protein. The S-100 protein is a marker of antigen-presenting dendritic cells (Gaillard et al, 1993;Matsuura et al, 1992;Sugimura et al, 1990;Uccini et al, 1986). Thus, S-100-labeled dendritic cells provide an index of immune function of the anal tonsil.…”

Section: Introductionmentioning

confidence: 98%

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The distribution of T lymphocytes, B lymphocytes, and dendritic‐like cells of the anal tonsil in the laboratory shrew, Suncus murinus

Sakai

Isomura

Shinzato

et al. 2010

Microscopy Res & Technique

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We investigated the distribution of T lymphocytes, B lymphocytes, and S-100 protein-immunoreactive dendritic-like in the anal tonsil of the laboratory shrew, Suncus murinus. In adult animals, T lymphocytes were located mainly at the periphery of the anal tonsil, especially around small blood vessels. B lymphocytes were located in the central and subepithelial region of the anal tonsil, which includes primary lymphoid follicles, and in which there are small numbers of scattered T lymphocytes. B and T lymphocytes were distributed over 72.7 and 27.3% of the tonsillar area, respectively. However, their areas of distribution were not clearly distinguished. The areas containing B lymphocytes were enriched in S-100 protein antibody-immunoreactive cells, which exhibited a dendritic shape. These S-100-positive cells appeared to be identical to the follicular dendritic cells (FDC) seen in the follicles of lymphoid organs. These results suggest that the anal tonsils constitute one of the gut-associated lymphoid tissues (GALT), and that a function of the anal tonsil includes the capture of intruding antigens that would generate protective antibody responses.

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