1972
DOI: 10.1159/000157909
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Ontogenic Development of Vascular Reactivity in Fast and Slow Muscles of the Neonatal Rat Hindlimb

Abstract: During the first three weeks of postnatal development the pattern of vascular reactivity typical of fast and slow muscle differentiates. In adult rat fast musclarteriolar smooth muscle cells are more sensitive to norepinephrine by several orders of magnitude than are those of slow muscle. In the early postnatal period there are no differences in the two types of muscle as far as vascular reactivity is concerned. At the time of weaning the vascular beds show almost the same reactivity patternas is found in the … Show more

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Cited by 4 publications
(3 citation statements)
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“…An increase in sensitivity of vascular smooth muscle to NA occurred simultaneously so that by the time of weaning, at about 21 days, the reactivity to exogenously administered NA was almost the same as in the adult rat (Gray 1972). An increase in sensitivity of vascular smooth muscle to NA occurred simultaneously so that by the time of weaning, at about 21 days, the reactivity to exogenously administered NA was almost the same as in the adult rat (Gray 1972).…”
Section: Discussionmentioning
confidence: 87%
See 1 more Smart Citation
“…An increase in sensitivity of vascular smooth muscle to NA occurred simultaneously so that by the time of weaning, at about 21 days, the reactivity to exogenously administered NA was almost the same as in the adult rat (Gray 1972). An increase in sensitivity of vascular smooth muscle to NA occurred simultaneously so that by the time of weaning, at about 21 days, the reactivity to exogenously administered NA was almost the same as in the adult rat (Gray 1972).…”
Section: Discussionmentioning
confidence: 87%
“…A remarkably similar time course for the development of skeletal muscle of the neonatal rat hindlimb into two functional types, fast and slow muscle, has been observed to occur during the first 3 weeks of postnatal life. An increase in sensitivity of vascular smooth muscle to NA occurred simultaneously so that by the time of weaning, at about 21 days, the reactivity to exogenously administered NA was almost the same as in the adult rat (Gray 1972).…”
Section: Discussionmentioning
confidence: 92%
“…In newborn rats, where the muscles are not different with respect to contraction speed (81) and metabolic characteristics of their fibers (293), the arterioles of fast (gastrocnemius) and slow (soleus) muscles are constricted to a similar degree by norepinephrine applied topically (149). However, by the 2nd wk after birth fast muscles exhibit both shorter contraction times (81) and greater sensitivity of the vasculature to norepinephrine (149). The two phenomena may be only fortuitously coupled, since in chickens the higher resting flow rate of slow muscle is not evident until after the differentiation of contraction speed and the enzyme profile of the muscle fibers (175).…”
Section: Skin Skeleton and Skeletal Musclementioning
confidence: 99%