Ontogenic Development of Vascular Reactivity in Fast and Slow Muscles of the Neonatal Rat Hindlimb

Gray, Sarah D.

doi:10.1159/000157909

Cited by 4 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increase in sensitivity of vascular smooth muscle to NA occurred simultaneously so that by the time of weaning, at about 21 days, the reactivity to exogenously administered NA was almost the same as in the adult rat (Gray 1972). An increase in sensitivity of vascular smooth muscle to NA occurred simultaneously so that by the time of weaning, at about 21 days, the reactivity to exogenously administered NA was almost the same as in the adult rat (Gray 1972).…”

Section: Discussionmentioning

confidence: 87%

“…A remarkably similar time course for the development of skeletal muscle of the neonatal rat hindlimb into two functional types, fast and slow muscle, has been observed to occur during the first 3 weeks of postnatal life. An increase in sensitivity of vascular smooth muscle to NA occurred simultaneously so that by the time of weaning, at about 21 days, the reactivity to exogenously administered NA was almost the same as in the adult rat (Gray 1972).…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Postnatal Ontogenetic Development of Neurogenic and Myogenic Control in the Rat Portal Vein

Ljung¹,

Stage²

1975

Acta Physiologica Scandinavica

View full text Add to dashboard Cite

The postnatal ontogenetic development of neuro-effector control in vascular smooth muscle of the single-unit type has been studied in the rat portal vein. Contractile activity was recorded isometrically in isolated preparations from rats 2-38 days of age and in adults rats. Spontaneous activity, characteristic of the adult portal vein, appeared abruptly during the third postnatal week. Whereas, induced responses to noradernaline (NA) and acetylcholine (Ach) appeared early during the first week and responses to transmural nerve stimulation occurred at the end of the first week. The appearance of spontaneous activity was accompanied by significant increases in sensitivity to NA (log ED50) and to transmural nerve stimulation (frequency giving half maximum response), but not to Ach. Also, maximum responses for NA and nerve stimulation relative to Ach responses tended to increase during the first three weeks. It is concluded that the development of a mechanism supporting myogenic propagation as revealed by highly synchronized spontaneous contractions is an important factor for promoting the effectiveness of sympathicoadrenergic control in this type of vascular smooth muscle.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 92%

Postnatal Ontogenetic Development of Neurogenic and Myogenic Control in the Rat Portal Vein

Ljung¹,

Stage²

1975

Acta Physiologica Scandinavica

View full text Add to dashboard Cite

show abstract

“…In newborn rats, where the muscles are not different with respect to contraction speed (81) and metabolic characteristics of their fibers (293), the arterioles of fast (gastrocnemius) and slow (soleus) muscles are constricted to a similar degree by norepinephrine applied topically (149). However, by the 2nd wk after birth fast muscles exhibit both shorter contraction times (81) and greater sensitivity of the vasculature to norepinephrine (149). The two phenomena may be only fortuitously coupled, since in chickens the higher resting flow rate of slow muscle is not evident until after the differentiation of contraction speed and the enzyme profile of the muscle fibers (175).…”

Section: Skin Skeleton and Skeletal Musclementioning

confidence: 99%

Neural and Endocrine Regulation of Circulation in the Fetus and Newborn

Mott

Walker

1983

Comprehensive Physiology

View full text Add to dashboard Cite

Subsarcolemmal mitochondria and capillarization of soleus muscle fibers in young rats subjected to an endurance training

Müller

1976

Cell Tissue Res.

100

View full text Add to dashboard Cite

Rats, 6 weeks old, were subjected to a program of endurance running for 3, 6 and 12 weeks. 0.5 to 0.8 mum thick sections of Epon embedded soleus muscles were studied with morphometric methods. In cross-sections the area occupied by subsarcolemmal mitochondria was independent of the age, but was 53% higher after 12 weeks of training. The mean depth of the zones with subsarcolemmal mitochondria increased only 15% to about 0.9 mum. Thus, the subsarcolemmal mitochondria showed a pronounced spreading at the muscle fiber surface in trained muscles.-The number of capillaries per fiber decreased slightly in controls and increased not significantly in trained muscles. It is concluded that the subsarcolemmal mitochondria supply the energy for the active transport of metabolites through the sarcolemma in oxidative muscle fibers, and that they are the limiting factor for endurance performance of the soleus muscle fibers because the changes in the capillarization were only small. It is suggested that the subsarcolemmal and the interfibrillar mitochondria have different functions and may therefore represent different types of mitochondria which can be distinguished by their morphology as well as by their biochemical properties.

show abstract

Ontogenic Development of Vascular Reactivity in Fast and Slow Muscles of the Neonatal Rat Hindlimb

Cited by 4 publications

References 6 publications

Postnatal Ontogenetic Development of Neurogenic and Myogenic Control in the Rat Portal Vein

Postnatal Ontogenetic Development of Neurogenic and Myogenic Control in the Rat Portal Vein

Neural and Endocrine Regulation of Circulation in the Fetus and Newborn

Subsarcolemmal mitochondria and capillarization of soleus muscle fibers in young rats subjected to an endurance training

Contact Info

Product

Resources

About