Ontogenetic expression of the Otx2 and Crx homeobox genes in the retina of the rat

Rath, Martin F.; Morin, Fabrice; Shi, Qiong; Klein, David C.; Møller, Mette

doi:10.1016/j.exer.2007.02.016

Cited by 50 publications

(68 citation statements)

References 38 publications

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“…The primary mechanism driving the increase is most likely due to the orchestrated expression of transcription factors (45)(46)(47). Our finding of marked developmental changes in the most abundant pineal miRNAs suggests an additional mechanism to control transcript and protein abundance, which may shape the development of the pineal gland.…”

Section: Pineal Mirna Populationmentioning

confidence: 78%

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MicroRNAs in the Pineal Gland

Clokie

Lau

Kim

et al. 2012

Journal of Biological Chemistry

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Background: MicroRNAs have not been studied in the pineal gland, the source of circulating melatonin. Results:The pineal miRNA population is profiled; developmental and tissue-specific patterns are described. The data suggest miR-483 perturbs melatonin production by promoting destruction of the Aanat transcript. Conclusion: miR-483 plays a physiological role in controlling melatonin synthesis. Significance: Pathophysiological changes in pineal miR-483 could alter melatonin synthesis.

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Section: Pineal Mirna Populationmentioning

confidence: 78%

“…Developmental Changes in miRNA Abundance Levels-As is true of all tissues, there are significant developmental changes in transcript levels in the pineal gland (45)(46)(47). The primary mechanism driving the increase is most likely due to the orchestrated expression of transcription factors (45)(46)(47).…”

Section: Pineal Mirna Populationmentioning

confidence: 99%

MicroRNAs in the Pineal Gland

Clokie

Lau

Kim

et al. 2012

Journal of Biological Chemistry

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“…Second, what miRNAs might mediate this process, and are they under direct cell cycle control, as is suggested by these results? With respect to the first question, no discordance in retinal protein and mRNA localization has been reported for Otx2, Vsx1, or Crx (the mammalian Otx5b orthologue) in the mouse (Baas et al, 2000;Hayashi et al, 2005;Rath et al, 2007), suggesting that these effects may be directly related to aspects of retinal development not shared between frogs and mammals. One potentially relevant feature is the far shorter duration of retinal neurogenesis in Xenopus than in mouse, roughly 24 hr as opposed to 22 days.…”

Section: Retinal Mirnas In Cell Fate Determinationmentioning

confidence: 99%

New meaning in the message: Noncoding RNAs and their role in retinal development

Rapicavoli

Blackshaw

2009

Developmental Dynamics

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Recent studies have indicated that non-protein-coding RNAs (ncRNAs) may play prominent and diverse roles in the development of the nervous system. These ncRNAs are now known to perform a broad range of cellular functions, and in particular appear to be prominent players in the regulation of transcription and translation. In this review, we discuss recent advances in our understanding of the role of ncRNAs in vertebrate retinal development. Noncoding RNAs that are known or suspected to play a functional role in the specification and maturation of retinal cell subtypes include miRNAs, long noncoding opposite-strand transcripts (OSTs), and other long ncRNAs such as Tug1 and RNCR2. Though the mechanism of action of most of these ncRNAs is still largely unclear, it is likely that these molecules represent a major, and thus far largely unappreciated, component of the molecular machinery involved in retinal cell fate specification.

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“…Autoradiographic in situ hybridization. The probes used are described in SI Appendix (45). RNA sequence analysis.…”

Section: Methodsmentioning

confidence: 99%

Circadian changes in long noncoding RNAs in the pineal gland

Coon

Munson

Cherukuri

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation of expression of genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day expression of 112 lncRNAs (0.3 to >50 kb) occurs in the rat pineal gland, which is the source of melatonin, the hormone of the night. Approximately one-half of these changes reflect nocturnal increases. Studies of eight lncRNAs with 2-to >100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5-1.3 h). Light exposure at night rapidly reverses (halving time = 9-32 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.RNA sequencing | neuroendocrine regulation | differential expression | chronobiology

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Ontogenetic expression of the Otx2 and Crx homeobox genes in the retina of the rat

Cited by 50 publications

References 38 publications

MicroRNAs in the Pineal Gland

MicroRNAs in the Pineal Gland

New meaning in the message: Noncoding RNAs and their role in retinal development

Circadian changes in long noncoding RNAs in the pineal gland

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