Ontogenetic changes to muscle architectural properties within the jaw‐adductor musculature of <i>Macaca fascicularis</i>

Dickinson, Edwin; Fitton, Laura C.; Kupczik, Kornelius

doi:10.1002/ajpa.23628

Cited by 33 publications

(21 citation statements)

References 87 publications

(172 reference statements)

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“…During ontogeny, the structure and function of masticatory muscles are necessary for the proper development of the mammalian TMJ, as well as mastication performance [13,16]. Moreover, the biomechanical input from the masticatory muscles is required during adulthood to maintain the homeostasis of the joint [17,18].…”

Section: Introductionmentioning

confidence: 99%

Mandibular Bone Loss after Masticatory Muscles Intervention with Botulinum Toxin: An Approach from Basic Research to Clinical Findings

Balanta‐Melo

Toro‐Ibacache

Kupczik

et al. 2019

Toxins

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The injection of botulinum toxin type A (BoNT/A) in the masticatory muscles, to cause its temporary paralysis, is a widely used intervention for clinical disorders such as oromandibular dystonia, sleep bruxism, and aesthetics (i.e., masseteric hypertrophy). Considering that muscle contraction is required for mechano-transduction to maintain bone homeostasis, it is relevant to address the bone adverse effects associated with muscle condition after this intervention. Our aim is to condense the current and relevant literature about mandibular bone loss in fully mature mammals after BoNT/A intervention in the masticatory muscles. Here, we compile evidence from animal models (mice, rats, and rabbits) to clinical studies, demonstrating that BoNT/A-induced masticatory muscle atrophy promotes mandibular bone loss. Mandibular bone-related adverse effects involve cellular and metabolic changes, microstructure degradation, and morphological alterations. While bone loss has been detected at the mandibular condyle or alveolar bone, cellular and molecular mechanisms involved in this process must still be elucidated. Further basic research could provide evidence for designing strategies to control the undesired effects on bone during the therapeutic use of BoNT/A. However, in the meantime, we consider it essential that patients treated with BoNT/A in the masticatory muscles be warned about a putative collateral mandibular bone damage.

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Section: Introductionmentioning

confidence: 99%

Mandibular Bone Loss after Masticatory Muscles Intervention with Botulinum Toxin: An Approach from Basic Research to Clinical Findings

Balanta‐Melo

Toro‐Ibacache

Kupczik

et al. 2019

Toxins

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“…The arrangement of muscle fascicles within the masticatory apparatus has been shown to correlate with dietary adaptations in both primates (Perry and Wall, ; Eng et al, ; Taylor and Vinyard, ; Perry and Hartstone‐Rose, ; Perry et al, ; Perry et al, ; Hartstone‐Rose et al, ) and other mammals (Taylor et al, ; Herrel et al, ; Hartstone‐Rose et al, ; Santana and Cheung, ; Fabre et al, ; Curtis and Santana, ; Santana, ). Despite our understanding of the relationship between fascicular architecture and masticatory function, however, few studies have considered how this architecture changes throughout the lifetime of an animal (Huhov et al, ; Langenbach and Weijs, ; Pfaller et al, ; Pfaller et al, ), especially within the primate order (though see Dickinson et al, ). Importantly, characterizing the architectural properties of muscles at various stages of life could provide valuable insights into dynamic functional demands throughout ontogeny and its impact upon the masticatory apparatus.…”

Section: Ontogeny Within Microcebus Murinusmentioning

confidence: 99%

“…From these inquiries, we have a better understanding of (1) the uniformity within different portions of the masticatory muscles (Antón, ), (2) the way that masticatory muscles are adapted to overcome mechanically disadvantaged leverages (e.g., prognathic faces; Antón, ; Antón, ), (3) the allometric scaling of the architectural properties of masticatory muscles (Anapol et al, ; Perry and Wall, ; Perry et al, ; Hartstone‐Rose et al, ), and (4) the correlations between masticatory muscle architecture and dietary processing and acquisition (Eng et al, ; Taylor and Vinyard, ; Perry et al, ; Hartstone‐Rose et al, ). However, only a few studies of primates have sought to clarify how these architectural properties might develop and change throughout the life of the animal (Carlson, ; Cachel, ; Dickinson et al, ; Prufrock and Perry, ).…”

Section: Ontogeny Within Microcebus Murinusmentioning

confidence: 99%

“…However, architectural properties of these muscles were not considered. More recently, Dickinson et al () investigated ontogenetic changes in muscle architecture across the adductor musculature of the crab‐eating macaque ( M. fascicularis ). They observed that muscle mass, PCSA, and fascicle lengths scaled with positive allometry relative to both jaw length and condyle‐molar length across the life span of their focal species (Dickinson et al, ).…”

Section: Ontogeny Within Microcebus Murinusmentioning

confidence: 99%

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The Ontogeny of Masticatory Muscle Architecture in Microcebus murinus

Leonard

Boettcher

Dickinson

et al. 2019

The Anatomical Record

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The masticatory apparatus has been the focus of many studies in comparative anatomy-especially analyses of skulls and teeth, but also of the mandibular adductor muscles which are responsible for the production of bite force and the movements of the mandible during food processing and transport. The fiber architecture of these muscles has been correlated to specific diets (e.g., prey size in felids) and modes of foraging (e.g., tree gouging in marmosets). Despite the well-elucidated functional implications of this architecture, little is known about its ontogeny. To characterize agerelated myological changes, we studied the masticatory muscles in a large (n = 33) intraspecific sample of a small, Malagasy primate, Microcebus murinus including neonatal through geriatric individuals. We removed each of the mandibular adductors and recorded its mass as well as other linear measurements. We then chemically dissected each muscle to study its architecture-fascicle length and physiological cross-sectional area (PCSA) which relate to stretch (gape) and force capabilities, respectively. We observed PCSA and muscle mass to increase rapidly and plateau in adulthood through senescence. Fascicle lengths remained relatively constant once maximal length was reached, which occurred early in life, suggesting that subsequent changes in PCSA are driven by changes in muscle mass. Quadratic curvilinear models of each of the architectural variables of all adductors combined as well as individual muscles regressed against age were all significant. Anat Rec, 303:1364Rec, 303: -1373Rec, 303: , 2020.The arrangement of muscle fascicles within the masticatory apparatus has been shown to correlate with dietary adaptations in both primates (Perry and Wall, 2008; Eng et al.

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“…Prediction 4: the magnitude of integration in the face and the mandibular ramus complex will increase throughout ontogeny as muscle mass and related loadings increase (Dickinson, Fitton, & Kupczik, 2018). For instance, muscle mass in the jaw‐adductor muscle (e.g., temporalis muscle) shows positive allometry throughout ontogeny in M. fascicularis (Dickinson et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Ontogenetic changes in magnitudes of integration in the macaque skull

Jung

Simons

Cramon‐Taubadel

2020

American J Phys Anthropol

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Objectives: Magnitudes of morphological integration may constrain or facilitate craniofacial shape variation. The aim of this study was to analyze how the magnitude of integration in the skull of Macaca fascicularis changes throughout ontogeny in relation to developmental and/or functional modules. Materials and methods: Geometric morphometric methods were used to analyze the magnitude of integration in the macaque cranium and mandible in 80 juvenile and 40 adult M. fascicularis specimens. Integration scores in skull modules were calculated using integration coefficient of variation (ICV) of eigenvalues based on a resampling procedure. Resultant ICV scores between the skull as a whole, and developmental and/or functional modules were compared using Mann-Whitney U tests. Results: Results showed that most skull modules were more tightly integrated than the skull as a whole, with the exception of the chondrocranium in juveniles without canines, the chondrocranium/face complex and the mandibular corpus in adults, and the mandibular ramus in all juveniles. The chondrocranium/face and face/mandibular corpus complexes were more tightly integrated in juveniles than adults, possibly reflecting the influences of early brain growth/development, and the changing functional demands of infant suckling and later masticatory loading. This is also supported by the much higher integration of the mandibular ramus in adults compared with juveniles. Discussion: Magnitudes of integration in skull modules reflect developmental/functional mechanisms in M. fascicularis. However, the relationship between "evolutionary flexibility" and developmental/functional mechanisms was not direct or simple, likely because of the complex morphology, multifunctionality, and various ossification origins of the skull.

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Ontogenetic changes to muscle architectural properties within the jaw‐adductor musculature of Macaca fascicularis

Cited by 33 publications

References 87 publications

Mandibular Bone Loss after Masticatory Muscles Intervention with Botulinum Toxin: An Approach from Basic Research to Clinical Findings

Mandibular Bone Loss after Masticatory Muscles Intervention with Botulinum Toxin: An Approach from Basic Research to Clinical Findings

The Ontogeny of Masticatory Muscle Architecture in Microcebus murinus

Ontogenetic changes in magnitudes of integration in the macaque skull

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