Ontogenetic and tissue-specific expression of gonadotropin-inhibitory hormone (GnIH) and its receptors in Catla catla

Kumar, Pravesh; Wisdom, K S; Kumar, Gulshan; Gireesh‐Babu, P.; Nayak, Sunil; Nagpure, N. S.; Sharma, Rupam

doi:10.1007/s11033-020-05388-5

Cited by 6 publications

(2 citation statements)

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“…Despite significant research aimed at determining the neurobiology underlying the developmental regulation of the reproductive axis, the switch that turns GnRH release off in infantile primates has received little attention. After the discovery of GnIH in the year 2000 [ 22 ], substantial research has been performed to establish its role in reproductive axis activity in many species [ 26 , 27 , 42 , 64 , 65 , 66 ]. To completely ascertain the role of GnIH in the conceptual brake on GnRH neuronal activity, we studied the pattern of expression of GnIH mRNA during pubertal development and its correlation with GnRH and Kiss1 gene expression.…”

Section: Discussionmentioning

confidence: 99%

“…A multitude of studies has confirmed the suppressive effect of GnIH on the synthesis and release of GnRH and pituitary gonadotropins as well as apoptosis of testicular tissues with seminiferous tubular regression [ 35 , 36 , 37 ]. Developmental variation in hypothalamic GnIH expression has been reported in various species, including zebrafish [ 38 ], Indian major carp [ 39 ], European bass [ 40 ], cichlids [ 41 ], catla [ 42 ], European green frogs [ 43 ], and mice [ 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

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Variation in Hypothalamic GnIH Expression and Its Association with GnRH and Kiss1 during Pubertal Progression in Male Rhesus Monkeys (Macaca mulatta)

Zubair

Saqib

Khan

et al. 2022

Animals

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Modulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion across postnatal development in higher primates is not fully understood. While gonadotropin-inhibitory hormone (GnIH) is reported to suppress reproductive axis activity in birds and rodents, little is known about the developmental trajectory of GnIH expression in rhesus monkeys throughout the pubertal transition. This study was aimed at examining the variation in GnIH immunoreactivity (-ir) and associated changes among GnIH, GnRH, and Kiss1 mRNA expression in the hypothalamus of infant, juvenile, prepubertal, and adult male rhesus monkeys. The brains from rhesus macaques were collected from infancy until adulthood and were examined using immunofluorescence and RT-qPCR. The mean GnIH-ir was found to be significantly higher in prepubertal animals (p < 0.01) compared to infants, and significantly reduced in adults (p < 0.001). Significantly higher (p < 0.001) GnRH and Kiss1 mRNA expression was noted in adults while GnIH mRNA expression was the highest at the prepubertal stage (p < 0.001). Significant negative correlations were seen between GnIH-GnRH (p < 0.01) and GnIH-Kiss1 (p < 0.001) expression. Our findings suggest a role for GnIH in the prepubertal suppression of the reproductive axis, with disinhibition of the adult reproductive axis occurring through decreases in GnIH. This pattern of expression suggests that GnIH may be a viable target for the development of novel therapeutics and contraceptives for humans.

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