Ontogenesis of hepatocyte respiration processes in relation to rat liver cytochrome P450-dependent monooxygenase system

Plewka, Andrzej; Kamiński, Marian; Plewka, Danuta

doi:10.1016/s0047-6374(98)00086-4

Cited by 17 publications

(4 citation statements)

References 27 publications

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“…The first is responsible to form electrochemical potential Dl H+ and the second one-to form lipid-radical cycles and to promote the activation of ANT. In general, the change in cytochrome b5 reductase activity may be considered a physiological event whereas cytochrome b5 loss which takes place during aging [89] is a pathology phenomenon. The basic value of our idea consists in that the mild decrease in the content of cytochrome b5 leads to two consequences, at least.…”

Section: Discussionmentioning

confidence: 99%

Shortage of Lipid-radical Cycles in Membranes as a Possible Prime Cause of Energetic Failure in Aging and Alzheimer Disease

Dmitriev

2007

Neurochem Res

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Polyunsaturated fatty acids (PUFA) and alpha-tocopherol (alpha-TOH) are the most oxygen-sensitive constituents of cells. alpha-TOH is a member of the vitamin E family that is considered the most important lipophilic antioxidant in cell membranes. Its importance is emphasized by the involvement of oxidative stress in injury to the central nervous system and neurodegenerative diseases. Currently, alpha-TOH transfer protein (TTP), is believed to play a significant role in maintaining the vitamin status but the presence of alpha-TOH in membranes is required but not sufficient to protect the membranes against lipid hydroperoxides (LOOH) formation. The lipid-radical theory presented in this review considers the role of two membrane factors--alpha-tocopherol and cytochrome b5; these factors secure the functioning of lipid-radical cycles and the participation of lipid-radical reactions in the key membrane processes. The prominent intermembrane reaction realized via a protein-lipid interaction, during which electron transport from cytochrome b5--located in the outer membrane--to peroxyl radical (LOO*)--located in inner membrane--causes reduction of the peroxyl radical: cyt.b5red + LOO* --> cyt.b5ox + LOO(-). This secures an interaction of alpha-TOH with other intermediate, LOO(- )excepting the LOOH formation. The discussion will be focused on the consequences of ineffective electron transfer to LOO* and excessive oxidative pathway of metabolism of the PUFA (LOO* --> LOOH). Assuming the operation of cytochrome b5/alpha-tocopherol-controlled lipid-radical cycles and considering the role of the cycles in membrane bioenergetics we arrive at a model for effective function of adenine nucleotide translocator and ATP synthesis in mitochondria. This paper summarizes our experimental evidence that the oxidative and non-oxidative pathways of metabolism of PUFA via their respective intermediates occur in the cells. While this fact is not widely appreciated it may be relevant to elucidation of new mechanisms of neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Shortage of Lipid-radical Cycles in Membranes as a Possible Prime Cause of Energetic Failure in Aging and Alzheimer Disease

Dmitriev

2007

Neurochem Res

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“…Based on a study performed with human lung and breast tumors, only a small variation in cytochrome P450 reductase activity in tumor tissues versus normal tissues was observed (Lopez de Cerain et al, 1999). Recently, it was shown that the specific activity of cytochrome P450 reductase may increase up to 1.8-fold in human liver cancer tissue compared with normal tissue (Plewka et al, 2000).…”

mentioning

confidence: 99%

Enzyme-Catalyzed Activation of Anticancer Prodrugs

2004

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“…P450R is a typical endoenzyme that attaches to the ER and catalyzes the reduction of cytochrome P450s by NADPH. A study on human liver cancer has shown a 1.75-fold increase in P450R activity in cancer tissues compared to normal liver tissues …”

Section: Abnormalities In Tumormentioning

confidence: 99%

“…A study on human liver cancer has shown a 1.75-fold increase in P450R activity in cancer tissues compared to normal liver tissues. 473 Carbonyl reductase (CR) is another NADPH-dependent oxidoreductase with broad catalytic activities in carbonyl compounds, such as quinones, doxorubicin, and daunorubicin. 474 An evaluation of 17 human lung tumors and 18 human breast tumors has shown a 2-and a 40-fold increase in CR activity relative to normal tissues.…”

Section: Biochemical and Molecular Abnormalitymentioning

confidence: 99%

Tumor Abnormality-Oriented Nanomedicine Design

Zhou,

Xiang,

Qiu

et al. 2023

Chem. Rev.

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Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic efficacy. Nanomedicines responsive to the pathological abnormalities in the tumor microenvironment (TME) are expected to overcome the biological limitations of conventional nanomedicines, enhance the therapeutic efficacies, and further reduce the side effects. This Review aims to quantitate the various pathological abnormalities in the TME, which may serve as unique endogenous stimuli for the design of stimuli-responsive nanomedicines, and to provide a broad and objective perspective on the current understanding of stimuli-responsive nanomedicines for cancer treatment. We dissect the typical transport process and barriers of cancer drug delivery, highlight the key design principles of stimuli-responsive nanomedicines designed to tackle the series of barriers in the typical drug delivery process, and discuss the “all-into-one” and “one-for-all” strategies for integrating the needed properties for nanomedicines. Ultimately, we provide insight into the challenges and future perspectives toward the clinical translation of stimuli-responsive nanomedicines.

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Ontogenesis of hepatocyte respiration processes in relation to rat liver cytochrome P450-dependent monooxygenase system

Cited by 17 publications

References 27 publications

Shortage of Lipid-radical Cycles in Membranes as a Possible Prime Cause of Energetic Failure in Aging and Alzheimer Disease

Shortage of Lipid-radical Cycles in Membranes as a Possible Prime Cause of Energetic Failure in Aging and Alzheimer Disease

Enzyme-Catalyzed Activation of Anticancer Prodrugs

Tumor Abnormality-Oriented Nanomedicine Design

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