Onset time course of solution induced corneal staining

Comparison of Ocular Comfort, Vision, and SICS During Silicone Hydrogel Contact Lens Daily Wear

“…These participants seem to have a lowered comfort level whether SICS was present at the time or not. This is important to note as previous work 9,26 has suggested that the best time to assess SICS is within 2 to 4 hrs of lens insertion. Our studies however were designed to replicate contact lens aftercare visits in a clinical, nonstudy setting whereby participants are observed by eye care practitioners at any time (in the first 3 months) of lens wear.…”

Clinical staining of the ocular surface: Mechanisms and interpretations

“…15). Timing varies according to the MPS formulation and the contact lens material used Andrasko and Ryen, 2008;Kislan, 2008;Bandamwar et al, 2010). In general the response is more common with the biguanides than with PQ-1 or Aldox .…”

“…This reaction has been referred to as Solution-Induced Corneal Staining (SICS) or Preservative-Associated Transient Hyperfluorescence (PATH) (Bright et al, 2012). Bandamwar et al (Bandamwar et al, 2010) recorded the development of corneal staining in subjects wearing PureVision™ SiHy lenses stored for 12 h overnight in ReNu Multiplus ® an MPS-containing Polyaminopropyl Biguanide 0.0001%. Staining was first detected at 15 min and increased in severity and extent and in the numbers of subjects affected, for up to 60 min after lens insertion, after which it levelled off.…”

Corneal staining

“…40,41,44 By contrast, a true toxicity reaction is typically pathological and symptomatic and may require several days to resolve. 45 The dichotomy between PATH and true corneal staining is highlighted by several observational differences.…”