Onset of the receptive and proceptive components of feminine sexual behavior in rats following the intravenous administration of progesterone

Glaser, Jeffrey H.; Rubin, Beverly S.; Barfield, Ronald J.

doi:10.1016/0018-506x(83)90012-0

Cited by 52 publications

(13 citation statements)

References 21 publications

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“…Other investigators have reported more immediate facilitation of lordosis behavior alone fol lowing intracranial progesterone implants as well as after intravenous administration of the hormone [16,18,24]. In contrast, studies in our laboratory utilizing threshold levels of estrogen priming have indicated that only submaximal levels of estrous behavior are exhibited 1 h after intravenous progesterone treatment and that full estrous responsiveness is not observed until 2 h after progesterone administration [10]. Similarly, in our laboratory only minimal levels of es trous responsiveness are observed 1 h after progesterone implants are lowered into experimental subjects primed systemicaily with threshold levels of estradiol [9,30], Thus, the differences between the time course of the appearance of es trous behavior following progesterone administration in our studies and the time course reported by other investiga tors cannot be resolved at the present, but one might suggest that they are due to differences in procedure and, possibly, differences among strains in sensitivity to behavioral effects of ovarian steroids.…”

Section: Discussioncontrasting

confidence: 45%

Induction of Estrous Behavior in Ovariectomized Rats by Sequential Replacement of Estrogen and Progesterone to the Ventromedial Hypothalamus

Rubin¹,

Barfield²

1983

Neuroendocrinology

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174

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The present experiment was designed to determine whether sequential replacement of estrogen and progesterone to the ventromedial hypothalamus (VMH) would be sufficient to induce estrous behavior in ovariectomized rats. Bilateral cannulae containing 17β-estradiol (E2) diluted with cholesterol (1:250) were lowered into the VMH, preoptic area or midbrain and left in place for 4 days. On day 5, the E2 inserts were removed and P-filled cannulae were lowered into half of the subjects. The remaining females received systemic progesterone (500 μg). This steroid regimen was repeated 2 weeks later with the mode of progesterone administration reversed. All subjects were tested for estrous behavior twice after progesterone treatment. In a second experiment, ³H-P:P-filled cannulae were lowered into the VMH of estrogen-primed females in order to estimate the extent of hormone spread from full-strength P-filled cannulae. Results indicated that estrogen and progesterone stimulation of the VMH is sufficient to activate estrous behavior in spayed female rats, however, precise localization of the hormone implants within the VMH is essential. 9 of the 11 females with both cannulae located within or at the border of the ventromedial nucleus (VMN) exhibited estrous behavior whereas only half of the females with only one implant resting in the VMN exhibited estrous responsiveness. Subjects with neither cannula located within or at the border of the VMN did not exhibit the behavior. The facilitative effects of P appeared to result from hormonal stimulation of the VMH and not from leakage of the steroid into other brain regions or into the systemic circulation. Following placement of tritiated progesterone implants into the VMH, high levels of radioactivity were recovered only from the mediobasal hypothalamus. The low levels of radioactivity measured in other brain regions, pituitary, uterus and blood indicate that relatively little if any hormone reached these tissues.

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Section: Discussioncontrasting

confidence: 45%

Induction of Estrous Behavior in Ovariectomized Rats by Sequential Replacement of Estrogen and Progesterone to the Ventromedial Hypothalamus

Rubin¹,

Barfield²

1983

Neuroendocrinology

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174

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“…For example, hypothalamic serotonin levels have been shown to be lower in estrous female rats than in intact male rats (Gundlah et al, 1998). Microdialysis studies indicate that decreases in 5-HT levels in the VMN after sequential treatment with estrogen and progesterone coincide with periods of maximal lordosis (Farmer et al, 1996;Glaser et al, 1983). Thus, we propose that different steroid hormones might regulate the serotonergic system that in turn establishes thresholds for the expression of male-like pseudosexual behavior, thereby "gating" the expression of behavioral repertoires.…”

Section: Discussionmentioning

confidence: 91%

Serotonergic modulation of male-like pseudocopulatory behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparens

Dias

Crews

2006

Hormones and Behavior

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Hormone-neurotransmitter interactions form an important link through which hormones influence a variety of behavioral processes. Typically, sexual behavior is dimorphic with males mounting receptive females. In the all-female lizard species Cnemidophorus uniparens, individuals display both male-like pseudocopulation and female-like receptivity. These respective behavioral states are correlated with high circulating concentrations of progesterone following ovulation and of estrogen preceding it. In sexual species, serotonin is involved in male-typical mounting, and, as reported here, in male-like pseudosexual behavior in this unisexual species. In the first study, C. uniparens were ovariectomized and treated systemically with exogenous androgen, a hormonal regimen that results in individuals displaying only male-like pseudosexual behavior. An increase in serotonin levels in the preoptic area coupled with the suppression of male-like pseudocopulation was observed in androgen-treated lizards injected with 5-hydroxytryptophan (the precursor of serotonin) and clorgyline (a monoamine oxidase inhibitor) compared to vehicle-treated controls. Our second experiment involved ovariectomizing lizards and either injecting them with estradiol or implanting them with either an empty (Blank) or a progesterone-or testosterone-containing Silastic capsule. Treatment with para-chlorophenylalanine (an inhibitor of tryptophan hydroxylase) facilitated malelike pseudosexual behavior depending on the circulating hormonal milieu and decreased serotonin levels in the preoptic area. Our data suggest that serotonin is inhibitory to male-like pseudosexual behavior in C. uniparens but more importantly that the hormonal environment modulates the serotonin system at the level of the preoptic area, with the serotonergic system then establishing behavioral thresholds that allow for this behavior to be "gated".

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“…It was originally believed that for Pto act as quickly as it had been shown to facilitate female sexual behavior after intravenous injection in rats (<10 minutes: [11]; < 30 minutes:[12]; 30 minutes [13, 14], the hormone probably acted via a mechanism distinct from that of E 2 [15], probably by a general membrane stabilization mechanism.…”

Section: Introductionmentioning

confidence: 99%

Neural Progestin Receptors and Female Sexual Behavior

Mani

Blaustein

2012

Neuroendocrinology

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The steroid hormone, progesterone (P), modulates neuroendocrine functions in the central nervous system resulting in integration of reproduction and reproductive behaviors in female mammals. Although it is widely recognized that P’s effects on female sex behavior are mediated by the classical neural progestin receptors (PRs) functioning as ‘ligand-dependent’ transcription factors to regulate genes and genomic networks, additional mechanisms of PR activation also contribute to the behavioral response. Cellular and molecular evidence indicates that PRs can be activated in a ligand-independent manner by neurotransmitters, growth factors, cyclic nucleotides, progestin metabolites and mating stimuli. The rapid responses of P may be mediated by a variety of PR types, including membrane-associated PRs or extranuclear PRs. Furthermore, these rapid nonclassical P actions involving cytoplasmic kinase signaling and/or extranuclear PRs also converge with classical PR-mediated transcription-dependent pathways to regulate reproductive behaviors. In this review, we summarize some of the history of the study of the role of PRs in reproductive behaviors and update the status of PR-mediated mechanisms involved in the facilitation of female sex behavior. We present an integrative model of PR activation via crosstalk and convergence of multiple signaling pathways.

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Onset of the receptive and proceptive components of feminine sexual behavior in rats following the intravenous administration of progesterone

Cited by 52 publications

References 21 publications

Induction of Estrous Behavior in Ovariectomized Rats by Sequential Replacement of Estrogen and Progesterone to the Ventromedial Hypothalamus

Induction of Estrous Behavior in Ovariectomized Rats by Sequential Replacement of Estrogen and Progesterone to the Ventromedial Hypothalamus

Serotonergic modulation of male-like pseudocopulatory behavior in the parthenogenetic whiptail lizard, Cnemidophorus uniparens

Neural Progestin Receptors and Female Sexual Behavior

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